公开(公告)号：US11274282B2

公开(公告)日：2022-03-15

申请号：US16875056

申请日：2020-05-15

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Sergio E. Rodriguez ,  Robert W. Cross ,  Chad E. Mire ,  Thomas W. Geisbert

IPC: A61K39/00 ,  A61K39/12 ,  A61K39/23 ,  C12N15/00 ,  C12N15/74 ,  C12N7/00 ,  C07K14/005 ,  A61K39/205 ,  C12N15/86 ,  G01N33/569 ,  A61P31/14

Abstract: Certain embodiments are directed generally to compositions and methods related to recombinant vesicular stomatitis virus vectors (ΔGrVSV) encoding Crimean-Congo Hemorrhagic Fever glycoprotein precursor (CCHFV-GPC) and forming a recombinant vesicular stomatitis virus vector encoding Crimean-Congo Hemorrhagic Fever glycoprotein precursor (ΔGrVSV-CCHFV-GPC).

公开(公告)号：US11198723B2

公开(公告)日：2021-12-14

申请号：US16466544

申请日：2017-12-05

Applicant: THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND ,  THE SCRIPPS RESEARCH INSTITUTE ,  THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM ,  ZALGEN LABS, LLC

Inventor： Luis M. Branco ,  Robert F. Garry ,  James E. Robinson ,  Erica O. Saphire ,  Kathryn M. Hastie ,  Thomas W. Geisbert

IPC: C07K16/10 ,  A61P31/14

Abstract: Disclosed herein are compositions comprising arenavirus monoclonal antibodies, as well as therapeutic, diagnostic, and preventative methods using the novel antibodies. Preventative methods include preparation of vaccines, as well as factors (e.g. small molecules, peptides) that inhibit Old World arenavirus infectivity, including LASV and LCMV. In some embodiments, the antibodies provide pan-arenavirus protection against a number of arenavirus types and strains. Diagnostic and therapeutic antibodies including neutralizing antibodies for the prevention and treatment of infection by LASV and other arenaviruses are also disclosed, as well as new tools and methods for the design, production, and use of arenavirus monoclonal antibodies, including expression in engineered bacterial- and mammalian-based systems.