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公开(公告)号：US20250034594A1
公开(公告)日：2025-01-30
申请号：US18687090
申请日：2022-09-01
Inventor： Le Cong
IPC: C12N15/90 , C12N9/22 , C12N15/11 , C12N15/115
Abstract: The present disclosure provides recombineering-editing systems using CRISPR and recombination enzymes as well as methods, vectors, nucleic acid compositions, and kits thereof. The methods and systems provide means for altering target DNA, including genomic DNA in a host cell.
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公开(公告)号：US20230091242A1
公开(公告)日：2023-03-23
申请号：US17905457
申请日：2021-03-02
Inventor： Le Cong
IPC: C12N9/22 , C12N15/11 , C12N15/62 , C12N15/115 , C12N15/90 , C07K14/245
Abstract: The present disclosure provides recombineering-editing systems using CRISPR and recombination enzymes as well as methods, vectors, nucleic acid compositions, and kits thereof. The methods and systems provide means for altering target DNA, including genomic DNA in a host cell.
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公开(公告)号：US20220204954A1
公开(公告)日：2022-06-30
申请号：US17605932
申请日：2020-04-24
Inventor： Le Cong
Abstract: The disclosure provides variant Staphylococcus aureus Cas9 (SaCas9) proteins with altered specificity for protospacer adjacent motif (PAM) sequences. The disclosure also is directed to CRISPR/Cas9 systems and methods of altering a genomic DNA sequence using the variant SaCas9 protein. Methods of generating variant Cas9 proteins with altered PAM specificity are also disclosed.
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公开(公告)号：US20240209447A1
公开(公告)日：2024-06-27
申请号：US18287619
申请日：2022-04-20
Inventor： Le Cong , Nicholas W. Hughes
IPC: C12Q1/6886 , C12N9/22 , C12N15/11 , C12Q1/44 , C12Q1/6813 , G16B20/50 , G16B25/30
CPC classification number: C12Q1/6886 , C12N9/22 , C12N15/111 , C12Q1/44 , C12Q1/6813 , G16B20/50 , G16B25/30 , C12N2310/20 , C12Q2600/158 , G01N2333/922
Abstract: The present disclosure provides systems, methods, nucleic acids, and kits for barcoding and tracking cells based on CRISPR editing technologies.
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