公开(公告)号：US20180028688A1

公开(公告)日：2018-02-01

申请号：US15662190

申请日：2017-07-27

Applicant: The Board of Trustees of the Leland Stanford Junior University

Inventor： Robert M. Waymouth ,  Paul Wender ,  Jessica R. Vargas ,  Tim R. Blake ,  Colin McKinlay ,  Ronald Levy ,  Ole Audun Werner Haabeth ,  Nancy Benner ,  Katherine Near

IPC: A61K48/00 ,  C12N15/85 ,  A61K47/69 ,  C12N15/115

CPC classification number: A61K48/0041 ,  A61K47/593 ,  A61K47/6883 ,  A61K47/6907 ,  A61K47/6931 ,  C12N15/1135 ,  C12N15/115 ,  C12N15/85 ,  C12N15/88

Abstract: There are provided herein, inter alia, complexes, compositions and methods for the delivery of therapeutic, diagnostic and imaging agents, including nucleic acid, into a cell. The complexes, compositions and methods may facilitate complexation, protection, delivery and release of oligonucleotides and polyanionic cargos into target cells, tissues, and organs both in vitro and in vivo.

公开(公告)号：US20240277870A1

公开(公告)日：2024-08-22

申请号：US18602410

申请日：2024-03-12

Applicant: The Board of Trustees of the Leland Stanford Junior University

Inventor： Robert M Waymouth ,  Paul Wender ,  Jessica R. Vargas ,  Tim R. Blake ,  Colin J. McKinlay ,  Ronald Levy ,  Ole Audun Werner Haabeth ,  Nancy Benner ,  Katherine Near

IPC: A61K48/00 ,  A61K47/59 ,  A61K47/68 ,  A61K47/69 ,  C12N15/113 ,  C12N15/115 ,  C12N15/85 ,  C12N15/88

CPC classification number: A61K48/0041 ,  A61K47/593 ,  A61K47/6907 ,  A61K47/6931 ,  C12N15/115 ,  C12N15/85 ,  C12N15/88 ,  A61K47/6883 ,  C12N15/1135

Abstract: There are provided herein, inter alia, complexes, compositions and methods for the delivery of therapeutic, diagnostic and imaging agents, including nucleic acid, into a cell. The complexes, compositions and methods may facilitate complexation, protection, delivery and release of oligonucleotides and polyanionic cargos into target cells, tissues, and organs both in vitro and in vivo.

公开(公告)号：US11931416B2

公开(公告)日：2024-03-19

申请号：US17427362

申请日：2020-01-31

Applicant: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

Inventor： Tim R. Blake ,  Paul Wender ,  Robert M. Waymouth ,  Ronald Levy ,  Ole Audun Werner Haabeth ,  Rebecca McClellan ,  Adrienne Sallets

IPC: A61K48/00 ,  A61K9/00 ,  A61K47/54 ,  A61K47/59 ,  C08G63/08 ,  C08G63/64 ,  C08G63/685 ,  C08G73/02

CPC classification number: A61K47/593 ,  A61K9/007 ,  A61K47/549 ,  A61K48/0041 ,  C08G63/08 ,  C08G63/64 ,  C08G63/685 ,  C08G73/028 ,  C08G73/0293

Abstract: There are provided herein, inter alia, cationic amphipathic polymers, complexes, and compositions comprising same, and methods for their use including for the delivery of therapeutic, diagnostic and imaging agents, including nucleic acids, into a cell. The complexes, compositions and methods may facilitate delivery and targeted release of the therapeutic, diagnostic and imaging agents to particular cell types and tissues.

公开(公告)号：US12215341B2

公开(公告)日：2025-02-04

申请号：US17292370

申请日：2019-11-11

Applicant: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

Inventor： Tim R. Blake ,  Robert M. Waymouth ,  Paul Wender ,  Ronald Levy ,  Ole Audun Werner Haabeth ,  Matthew Frank ,  Adrienne Sallets

IPC: A61K39/00 ,  A61K47/69 ,  A61P35/00 ,  A61P37/04 ,  C08G63/64 ,  C08G64/02 ,  C12N15/88 ,  C12N15/90

Abstract: There are provided herein, inter alia, complexes, compositions and methods for the delivery of nucleic acid into a cell in vivo. The complexes, compositions and methods may facilitate complexation, protection, delivery and release of oligonucleotides and polyanionic cargos into target cells, tissues, and organs both in vitro and in vivo.

公开(公告)号：US20240277854A1

公开(公告)日：2024-08-22

申请号：US18428147

申请日：2024-01-31

Applicant: The Board of Trustees of the Leland Stanford Junior University

Inventor： Tim R. Blake ,  Paul Wender ,  Robert Waymouth ,  Ronald Levy ,  Ole Haabeth ,  Rebecca Mcclellan ,  Adrienne Sallets

IPC: A61K47/59 ,  A61K9/00 ,  A61K47/54 ,  A61K48/00 ,  C08G63/08 ,  C08G63/64 ,  C08G63/685 ,  C08G73/02

CPC classification number: A61K47/593 ,  A61K9/007 ,  A61K47/549 ,  A61K48/0041 ,  C08G63/08 ,  C08G63/64 ,  C08G63/685 ,  C08G73/028 ,  C08G73/0293

Abstract: There are provided herein, inter alia, complexes, compositions and methods for the delivery of therapeutic, diagnostic and imaging agents, including nucleic acid, into a cell. The complexes, compositions and methods may facilitate complexation, protection, delivery and release of oligonucleotides and polyanionic cargos into lung cells and lung tissue, both in vitro and in vivo.