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公开(公告)号：US20190085280A1
公开(公告)日：2019-03-21
申请号：US16137478
申请日：2018-09-20
摘要： A device for treatment of cells with particles is disclosed. The device includes a semi-permeable membrane positioned between two plates, the first plate defining a first flow chamber and comprising a port, a flow channel, a transverse port, and a transverse flow channel, the first flow chamber constructed and arranged to deliver fluid in a transverse direction along the first side of the semi-permeable membrane, the second plate defining a second flow chamber and comprising a port. A method for transducing cells is disclosed. The method includes introducing a fluid with cells and viral particles into a flow chamber adjacent a semi-permeable membrane such that the cells and the viral particles are substantially evenly distributed on the semi-permeable membrane. The method also includes introducing a recovery fluid to suspend the cells and the viral particles, and separating the cells from the viral particles. A method of activating cells is disclosed.
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公开(公告)号：US20230063282A1
公开(公告)日：2023-03-02
申请号：US17946948
申请日：2022-09-16
发明人： Kenneth T. Kotz , Bryan D. Teece , James Gillett Truslow , Nathan Francis Moore , Jeffrey T. Borenstein , Vishal Tandon
摘要： A device for treatment of cells with particles is disclosed. The device includes a semi-permeable membrane positioned between two plates, the first plate defining a first flow chamber and comprising a port, a flow channel, a transverse port, and a transverse flow channel, the first flow chamber constructed and arranged to deliver fluid in a transverse direction along the first side of the semi-permeable membrane, the second plate defining a second flow chamber and comprising a port. A method for transducing cells is disclosed. The method includes introducing a fluid with cells and viral particles into a flow chamber adjacent a semi-permeable membrane such that the cells and the viral particles are substantially evenly distributed on the semi-permeable membrane. The method also includes introducing a recovery fluid to suspend the cells and the viral particles, and separating the cells from the viral particles. A method of activating cells is disclosed.
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公开(公告)号：US20200292287A1
公开(公告)日：2020-09-17
申请号：US16811906
申请日：2020-03-06
摘要： A projectile includes a body and a power generator secured to the body. The power generator includes a stator and a ring including at least one magnet and extending radially around and freely rotatable about at least a portion of the stator. A power generator for a projectile is also provided.
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公开(公告)号：US20230080444A1
公开(公告)日：2023-03-16
申请号：US17946862
申请日：2022-09-16
发明人： Kenneth T. Kotz , Bryan D. Teece , James Gillett Truslow , Nathan Francis Moore , Jeffrey T. Borenstein , Vishal Tandon
摘要： A device for treatment of cells with particles is disclosed. The device includes a semi-permeable membrane positioned between two plates, the first plate defining a first flow chamber and comprising a port, a flow channel, a transverse port, and a transverse flow channel, the first flow chamber constructed and arranged to deliver fluid in a transverse direction along the first side of the semi-permeable membrane, the second plate defining a second flow chamber and comprising a port. A method for transducing cells is disclosed. The method includes introducing a fluid with cells and viral particles into a flow chamber adjacent a semi-permeable membrane such that the cells and the viral particles are substantially evenly distributed on the semi-permeable membrane. The method also includes introducing a recovery fluid to suspend the cells and the viral particles, and separating the cells from the viral particles. A method of activating cells is disclosed.
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公开(公告)号：US11584908B2
公开(公告)日：2023-02-21
申请号：US16137478
申请日：2018-09-20
发明人： Kenneth T. Kotz , Bryan D. Teece , James Gillett Truslow , Nathan Francis Moore , Jeffrey T. Borenstein , Vishal Tandon
IPC分类号： C12M1/02 , C12M1/12 , C12N15/87 , C12M1/00 , C12N15/86 , C12M3/06 , C12M1/40 , C12M1/34 , A61K48/00
摘要： A device for treatment of cells with particles is disclosed. The device includes a semi-permeable membrane positioned between two plates, the first plate defining a first flow chamber and comprising a port, a flow channel, a transverse port, and a transverse flow channel, the first flow chamber constructed and arranged to deliver fluid in a transverse direction along the first side of the semi-permeable membrane, the second plate defining a second flow chamber and comprising a port. A method for transducing cells is disclosed. The method includes introducing a fluid with cells and viral particles into a flow chamber adjacent a semi-permeable membrane such that the cells and the viral particles are substantially evenly distributed on the semi-permeable membrane. The method also includes introducing a recovery fluid to suspend the cells and the viral particles, and separating the cells from the viral particles. A method of activating cells is disclosed.
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公开(公告)号：US11525654B2
公开(公告)日：2022-12-13
申请号：US16811906
申请日：2020-03-06
IPC分类号： F42B12/38 , H02K1/2786
摘要： A projectile includes a body and a power generator secured to the body. The power generator includes a stator and a ring including at least one magnet and extending radially around and freely rotatable about at least a portion of the stator. A power generator for a projectile is also provided.
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