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    COMPOUNDS, SYSTEMS, AND METHODS FOR MONITORING AND TREATING A SURFACE OF A SUBJECT
    1.
    发明申请
    COMPOUNDS, SYSTEMS, AND METHODS FOR MONITORING AND TREATING A SURFACE OF A SUBJECT 审中-公开

    公开(公告)号：US20200171172A1

    公开(公告)日：2020-06-04

    申请号：US16787480

    申请日：2020-02-11

    Applicant: The General Hospital Corporation

    Inventor： Conor L. Evans ,  Gabriela Apiou ,  Alexander J. Nichols ,  Emmanouil Rousakis ,  Zongxi Li

    IPC: A61K49/00 ,  C07D487/22 ,  A61B5/00 ,  A61B5/1455 ,  A61B90/00

    Abstract: Compounds, systems, and methods are provided for the design and assembly of a non-invasive, analyte sensing dressing. The dressing can be therapeutic. The dressing includes a sensor and a matrix. The sensor is capable of detecting analytes such as molecular oxygen, carbon dioxide, nitric oxides, dissolved analytes in plasma, and hydrogen ions. The matrix is at least partially permeable to the analyte. The device emits a detectable signal when the sensor is excited in the presence of the analyte. In one version of the dressing, the sensor includes a meso-unsubstituted metallated porphyrin that is sensitive towards oxygen. The metallated porphyrin can be excited when illuminated at a first wavelength, followed by emission of phosphorescence at a second wavelength whose intensity can be used as an indicator for oxygen concentration.

    COMPOUNDS, SYSTEMS, AND METHODS FOR MONITORING AND TREATING A SURFACE OF A SUBJECT
    2.
    发明申请
    COMPOUNDS, SYSTEMS, AND METHODS FOR MONITORING AND TREATING A SURFACE OF A SUBJECT 有权

    公开(公告)号：US20220257797A1

    公开(公告)日：2022-08-18

    申请号：US17583997

    申请日：2022-01-25

    Applicant: The General Hospital Corporation

    Inventor： Conor L. Evans ,  Gabriela Apiou ,  Alexander J. Nichols ,  Emmanouil Rousakis ,  Zongxi Li

    IPC: A61K49/00 ,  A61B5/00 ,  A61B5/1455 ,  A61B90/00 ,  C07D487/22

    Abstract: Compounds, systems, and methods are provided for the design and assembly of a non-invasive, analyte sensing dressing. The dressing can be therapeutic. The dressing includes a sensor and a matrix. The sensor is capable of detecting analytes such as molecular oxygen, carbon dioxide, nitric oxides, dissolved analytes in plasma, and hydrogen ions. The matrix is at least partially permeable to the analyte. The device emits a detectable signal when the sensor is excited in the presence of the analyte. In one version of the dressing, the sensor includes a meso-unsubstituted metallated porphyrin that is sensitive towards oxygen. The metallated porphyrin can be excited when illuminated at a first wavelength, followed by emission of phosphorescence at a second wavelength whose intensity can be used as an indicator for oxygen concentration.

    Compounds, systems, and methods for monitoring and treating a surface of a subject
    3.
    发明授权
    Compounds, systems, and methods for monitoring and treating a surface of a subject 有权

    公开(公告)号：US11253613B2

    公开(公告)日：2022-02-22

    申请号：US16787480

    申请日：2020-02-11

    Applicant: The General Hospital Corporation

    Inventor： Conor L. Evans ,  Gabriela Apiou ,  Alexander J. Nichols ,  Emmanouil Rousakis ,  Zongxi Li

    IPC: C07D487/22 ,  A61K49/00 ,  A61B5/00 ,  A61B5/1455 ,  A61B90/00 ,  A61F13/00

    Abstract: Compounds, systems, and methods are provided for the design and assembly of a non-invasive, analyte sensing dressing that includes a sensor and a matrix. The sensor is capable of detecting analytes such as molecular oxygen. The matrix is at least partially permeable to the analyte. In one version of the dressing, the sensor includes a meso-unsubstituted metallated porphyrin that is sensitive towards oxygen. The metallated porphyrin can be excited when illuminated at a first wavelength, followed by emission of phosphorescence at a second wavelength whose intensity can be used as an indicator for oxygen concentration. The metallated porphyrin can be prepared from a phosphorescent meso-unsubstituted porphyrin having the Formula (I): wherein M is a metal, wherein each R is independently an atom or a group of atoms, and wherein at least one R is —O(C)OR′, wherein R′ is optionally substituted alkyl.

    Compounds, systems, and methods for monitoring and treating a surface of a subject
    4.
    发明授权
    Compounds, systems, and methods for monitoring and treating a surface of a subject 有权

    公开(公告)号：US10039842B2

    公开(公告)日：2018-08-07

    申请号：US15684040

    申请日：2017-08-23

    Applicant: THE GENERAL HOSPITAL CORPORATION

    Inventor： Conor L. Evans ,  Gabriela Apiou ,  Alexander J. Nichols ,  Emmanouil Rousakis ,  Zongxi Li

    IPC: A61K49/00 ,  A61B5/00 ,  A61B5/1455 ,  C07D487/22

    Abstract: Compounds, systems, and methods are provided for the design and assembly of a non-invasive, analyte sensing dressing. The dressing includes a sensor and a matrix. The sensor is capable of detecting analytes such as molecular oxygen, carbon dioxide, nitric oxides, dissolved analytes in plasma, and hydrogen ions. The device emits a detectable signal when the sensor is excited in the presence of the analyte. In one version of the dressing, the sensor includes a meso-unsubstituted metallated porphyrin that is sensitive towards oxygen. The metallated porphyrin can be excited when illuminated at a first wavelength, followed by emission of phosphorescence at a second wavelength whose intensity can be used as an indicator for oxygen concentration. The porphyrin can have the Formula (II): wherein R1 includes a moiety selected from the group consisting of alkynl groups, triazolyl groups, alkylglutamate groups, and a pair of alkylglutamate groups.

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