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    System and method for photoluminescence detection
    1.
    发明授权
    System and method for photoluminescence detection 有权

    公开(公告)号：US10524707B2

    公开(公告)日：2020-01-07

    申请号：US15114951

    申请日：2015-02-02

    Applicant: THE GENERAL HOSPITAL CORPORATION

    Inventor： Zongxi Li ,  Conor L. Evans ,  Alexander J. Nichols

    IPC: A61B5/1455 ,  A61B5/1477 ,  A61B5/00 ,  A61F13/00

    Abstract: In one aspect, the present disclosure provides a system A system, including a light source, a detector, and a controller in electrical communication with the light source and the detector. The controller is configured to execute a program stored in the controller to trigger the light source to emit a first pulse of light having a first pulse duration for illumination of a target, actuate the detector after a first delay time following emission of the first pulse of light to begin detecting a first signal from the target for a first detection time, and repeat the steps of triggering the light source and actuating the detector at least once, varying for each repetition at least one of the first pulse duration, the first delay time, and the first detection time.

    SYSTEMS AND METHODS FOR MONITORING AN ANALYTE OR PARAMETER FOR A PATIENT
    2.
    发明公开
    SYSTEMS AND METHODS FOR MONITORING AN ANALYTE OR PARAMETER FOR A PATIENT 审中-公开

    公开(公告)号：US20230263392A1

    公开(公告)日：2023-08-24

    申请号：US18043659

    申请日：2021-09-01

    Applicant: The General Hospital Corporation

    Inventor： Juan Pedro Cascales Sandoval ,  Conor L. Evans

    IPC: A61B5/00

    CPC classification number: A61B5/0008 ,  A61B2562/02

    Abstract: A sensor system includes a probe, and a photon source configured to direct photons at the probe. The probe can emit light in response to receiving photons. The sensor system can include a photodetector configured to detect the light emitted from the probe, and a configured to cause the photon source to emit photons according to a first time-varying intensity profile having a first frequency. The controller can be configured to receive optical data from the photodetector based on the interaction between the light emitted from the probe and the photodetector. The optical data can include a second time-varying intensity profile having a second frequency. The second frequency can be substantially the same as the first frequency. The controller can be configured to determine a difference in phase between the first time-varying intensity profile and the second time-varying intensity profile, and generate a report based on the difference in phase.

    COMPOUNDS, SYSTEMS, AND METHODS FOR MONITORING AND TREATING A SURFACE OF A SUBJECT
    3.
    发明申请
    COMPOUNDS, SYSTEMS, AND METHODS FOR MONITORING AND TREATING A SURFACE OF A SUBJECT 审中-公开

    公开(公告)号：US20200171172A1

    公开(公告)日：2020-06-04

    申请号：US16787480

    申请日：2020-02-11

    Applicant: The General Hospital Corporation

    Inventor： Conor L. Evans ,  Gabriela Apiou ,  Alexander J. Nichols ,  Emmanouil Rousakis ,  Zongxi Li

    IPC: A61K49/00 ,  C07D487/22 ,  A61B5/00 ,  A61B5/1455 ,  A61B90/00

    Abstract: Compounds, systems, and methods are provided for the design and assembly of a non-invasive, analyte sensing dressing. The dressing can be therapeutic. The dressing includes a sensor and a matrix. The sensor is capable of detecting analytes such as molecular oxygen, carbon dioxide, nitric oxides, dissolved analytes in plasma, and hydrogen ions. The matrix is at least partially permeable to the analyte. The device emits a detectable signal when the sensor is excited in the presence of the analyte. In one version of the dressing, the sensor includes a meso-unsubstituted metallated porphyrin that is sensitive towards oxygen. The metallated porphyrin can be excited when illuminated at a first wavelength, followed by emission of phosphorescence at a second wavelength whose intensity can be used as an indicator for oxygen concentration.

    COMPOUNDS, SYSTEMS, AND METHODS FOR MONITORING AND TREATING A SURFACE OF A SUBJECT
    4.
    发明申请
    COMPOUNDS, SYSTEMS, AND METHODS FOR MONITORING AND TREATING A SURFACE OF A SUBJECT 有权

    公开(公告)号：US20220257797A1

    公开(公告)日：2022-08-18

    申请号：US17583997

    申请日：2022-01-25

    Applicant: The General Hospital Corporation

    Inventor： Conor L. Evans ,  Gabriela Apiou ,  Alexander J. Nichols ,  Emmanouil Rousakis ,  Zongxi Li

    IPC: A61K49/00 ,  A61B5/00 ,  A61B5/1455 ,  A61B90/00 ,  C07D487/22

    Abstract: Compounds, systems, and methods are provided for the design and assembly of a non-invasive, analyte sensing dressing. The dressing can be therapeutic. The dressing includes a sensor and a matrix. The sensor is capable of detecting analytes such as molecular oxygen, carbon dioxide, nitric oxides, dissolved analytes in plasma, and hydrogen ions. The matrix is at least partially permeable to the analyte. The device emits a detectable signal when the sensor is excited in the presence of the analyte. In one version of the dressing, the sensor includes a meso-unsubstituted metallated porphyrin that is sensitive towards oxygen. The metallated porphyrin can be excited when illuminated at a first wavelength, followed by emission of phosphorescence at a second wavelength whose intensity can be used as an indicator for oxygen concentration.

    Compounds, systems, and methods for monitoring and treating a surface of a subject
    5.
    发明授权
    Compounds, systems, and methods for monitoring and treating a surface of a subject 有权

    公开(公告)号：US11253613B2

    公开(公告)日：2022-02-22

    申请号：US16787480

    申请日：2020-02-11

    Applicant: The General Hospital Corporation

    Inventor： Conor L. Evans ,  Gabriela Apiou ,  Alexander J. Nichols ,  Emmanouil Rousakis ,  Zongxi Li

    IPC: C07D487/22 ,  A61K49/00 ,  A61B5/00 ,  A61B5/1455 ,  A61B90/00 ,  A61F13/00

    Abstract: Compounds, systems, and methods are provided for the design and assembly of a non-invasive, analyte sensing dressing that includes a sensor and a matrix. The sensor is capable of detecting analytes such as molecular oxygen. The matrix is at least partially permeable to the analyte. In one version of the dressing, the sensor includes a meso-unsubstituted metallated porphyrin that is sensitive towards oxygen. The metallated porphyrin can be excited when illuminated at a first wavelength, followed by emission of phosphorescence at a second wavelength whose intensity can be used as an indicator for oxygen concentration. The metallated porphyrin can be prepared from a phosphorescent meso-unsubstituted porphyrin having the Formula (I): wherein M is a metal, wherein each R is independently an atom or a group of atoms, and wherein at least one R is —O(C)OR′, wherein R′ is optionally substituted alkyl.

    Non-invasive visualization and quantification of natural pigments
    6.
    发明授权
    Non-invasive visualization and quantification of natural pigments 有权

    公开(公告)号：US10653355B2

    公开(公告)日：2020-05-19

    申请号：US15545488

    申请日：2016-02-05

    Applicant: THE GENERAL HOSPITAL CORPORATION

    Inventor： Hequn Wang ,  Conor L. Evans ,  Sam Osseiran ,  David E. Fisher

    IPC: A61B5/00 ,  G01J3/44 ,  G01N21/88 ,  G01N21/17 ,  G01N21/41 ,  G01N21/65

    Abstract: A system for visualizing melanin present in tissue can include an imaging system to record a signal based on a presence of melanin in tissue and a display device to display an image based on the signal. A first laser source can emit a Stokes pulse train and a second laser source can emit a pump pulse train. Both the first laser source and the second laser source comprise a tunable center wavelength or frequency. An energy difference between a frequency of the Stokes pulse train and a frequency of the pump pulse train is from 1750 cm−1 to 2250 cm−1. The Stokes and the pump pulse train overlap in space and time. A scanning mechanism focuses the combined Stokes pulse train and pump pulse train within the tissue and scans across the tissue. A detector detects the signal based on a presence of melanin within the tissue.

    Compounds, systems, and methods for monitoring and treating a surface of a subject
    7.
    发明授权
    Compounds, systems, and methods for monitoring and treating a surface of a subject 有权

    公开(公告)号：US10039842B2

    公开(公告)日：2018-08-07

    申请号：US15684040

    申请日：2017-08-23

    Applicant: THE GENERAL HOSPITAL CORPORATION

    Inventor： Conor L. Evans ,  Gabriela Apiou ,  Alexander J. Nichols ,  Emmanouil Rousakis ,  Zongxi Li

    IPC: A61K49/00 ,  A61B5/00 ,  A61B5/1455 ,  C07D487/22

    Abstract: Compounds, systems, and methods are provided for the design and assembly of a non-invasive, analyte sensing dressing. The dressing includes a sensor and a matrix. The sensor is capable of detecting analytes such as molecular oxygen, carbon dioxide, nitric oxides, dissolved analytes in plasma, and hydrogen ions. The device emits a detectable signal when the sensor is excited in the presence of the analyte. In one version of the dressing, the sensor includes a meso-unsubstituted metallated porphyrin that is sensitive towards oxygen. The metallated porphyrin can be excited when illuminated at a first wavelength, followed by emission of phosphorescence at a second wavelength whose intensity can be used as an indicator for oxygen concentration. The porphyrin can have the Formula (II): wherein R1 includes a moiety selected from the group consisting of alkynl groups, triazolyl groups, alkylglutamate groups, and a pair of alkylglutamate groups.

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