公开(公告)号：US20150132384A1

公开(公告)日：2015-05-14

申请号：US14382495

申请日：2013-03-04

申请人： The Governing Council of the University of Toronto

发明人： Xiao Yu Wu ,  Alireza Shalviri ,  Ping Cai

IPC分类号： C08F251/00 ,  A61K9/14 ,  A61K31/197 ,  A61K47/36 ,  A61K38/08 ,  A61K31/704 ,  A61K47/32

CPC分类号： C08F251/00 ,  A61K9/14 ,  A61K9/5161 ,  A61K9/5192 ,  A61K31/197 ,  A61K31/704 ,  A61K38/08 ,  A61K47/32 ,  A61K47/36 ,  A61K49/0093 ,  A61K49/1818 ,  A61K49/1881 ,  B82Y40/00 ,  C08F8/00 ,  C08J3/14 ,  C08F222/1006 ,  C08F220/34 ,  C08F220/06 ,  C08F2220/286 ,  C08F2220/1891

摘要： Synthesis and characterization of starch based pH-responsive nanoparticles for controlled drug delivery are described. Polymethacrylic acid grafted starch (PMAA-g-St) nanoparticles with various molar ratio of starch to MAA were synthesized by a new one-pot method that enabled simultaneous grafting of PMAA and nanoparticle formation in an aqueous medium. NMR data showed that polysorbate 80 was polymerized into the graft polymer. Nanoparticles were relatively spherical with narrow size distribution and porous surface morphology and exhibited pH-dependent swelling in physiological pH range. The particle size and magnitude of volume phase transition were dependent on PMAA content and formulation parameters such as surfactant levels, cross-linker amount, and total monomer concentration. The results showed that the new pH-responsive nanoparticles possessed useful properties for controlled drug delivery.

摘要翻译： 描述了用于控制药物递送的淀粉基pH响应纳米颗粒的合成和表征。 通过新的一锅法合成了具有各种摩尔比的淀粉与MAA的聚甲基丙烯酸接枝淀粉（PMAA-g-St）纳米粒子，其能够在水性介质中同时接枝PMAA和纳米颗粒形成。 NMR数据显示聚山梨醇酯80聚合成接枝聚合物。 纳米颗粒相对球形，具有窄尺寸分布和多孔表面形态，并在生理pH范围内显示pH依赖性溶胀。 体积相变的粒度和大小取决于PMAA含量和制剂参数，如表面活性剂水平，交联剂量和总单体浓度。 结果表明，新的pH响应纳米粒子具有控制药物递送的有用性质。

公开(公告)号：US11155664B2

公开(公告)日：2021-10-26

申请号：US16229763

申请日：2018-12-21

申请人： THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

发明人： Xiao Yu Wu ,  Alireza Shalviri ,  Ping Cai

IPC分类号： C08F251/00 ,  A61K49/18 ,  C08J3/14 ,  C08F8/00 ,  A61K9/51 ,  A61K49/00 ,  A61K9/14 ,  A61K31/197 ,  A61K31/704 ,  A61K47/32 ,  A61K47/36 ,  B82Y40/00

摘要： Synthesis and characterization of starch based pH-responsive nanoparticles for controlled drug delivery are described. Polymethacrylic acid grafted starch (PMAA-g-St) nanoparticles with various molar ratio of starch to MAA were synthesized by a new one-pot method that enabled simultaneous grafting of PMAA and nanoparticle formation in an aqueous medium. NMR data showed that polysorbate 80 was polymerized into the graft polymer. Nanoparticles were relatively spherical with narrow size distribution and porous surface morphology and exhibited pH-dependent swelling in physiological pH range. The particle size and magnitude of volume phase transition were dependent on PMAA content and formulation parameters such as surfactant levels, cross-linker amount, and total monomer concentration. The results showed that the new pH-responsive nanoparticles possessed useful properties for controlled drug delivery.

公开(公告)号：US10233277B2

公开(公告)日：2019-03-19

申请号：US14382495

申请日：2013-03-04

申请人： The Governing Council of the University of Toronto

发明人： Xiao Yu Wu ,  Alireza Shalviri ,  Ping Cai

IPC分类号： C08F251/00 ,  A61K9/14 ,  A61K31/197 ,  A61K47/36 ,  A61K38/08 ,  A61K31/704 ,  A61K47/32 ,  C08J3/14 ,  C08F8/00 ,  A61K9/51 ,  A61K49/00 ,  A61K49/18 ,  B82Y40/00

摘要： Synthesis and characterization of starch based pH-responsive nanoparticles for controlled drug delivery are described. Polymethacrylic acid grafted starch (PMAA-g-St) nanoparticles with various molar ratio of starch to MAA were synthesized by a new one-pot method that enabled simultaneous grafting of PMAA and nanoparticle formation in an aqueous medium. NMR data showed that polysorbate 80 was polymerized into the graft polymer. Nanoparticles were relatively spherical with narrow size distribution and porous surface morphology and exhibited pH-dependent swelling in physiological pH range. The particle size and magnitude of volume phase transition were dependent on PMAA content and formulation parameters such as surfactant levels, cross-linker amount, and total monomer concentration. The results showed that the new pH-responsive nanoparticles possessed useful properties for controlled drug delivery.