公开(公告)号：US20190085333A1

公开(公告)日：2019-03-21

申请号：US16078760

申请日：2017-02-24

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： David Lee Thomas ,  Ashwin Balagopal ,  Ramy El-Diwany ,  Robert Siliciano ,  Joel Blankson ,  Stuart C Ray ,  Michel Anand Chattergoon ,  Justin Bailey

IPC分类号： C12N15/113 ,  A61P31/18 ,  A61K38/00

摘要： Three proteins, BCL-G (BCL2L14), CMPK2, and LAMP3, were discovered to independently restrict HIV-1 replication both in-vivo and in-vitro. Methods are described wherein subjects are given an effective amount of a pharmaceutical composition comprising a protein selected from the group consisting of BCL-G, CMPK2, LAMP3, functional parts thereof, recombinant proteins thereof, and combinations thereof, for the purpose of treating or preventing HIV.

公开(公告)号：US10806748B2

公开(公告)日：2020-10-20

申请号：US15568893

申请日：2016-04-22

申请人： The Johns Hopkins University

发明人： Katherine Bruner ,  Robert Siliciano

IPC分类号： C12Q1/68 ,  A61K31/711 ,  C12Q1/6806 ,  C12Q1/70 ,  A61P31/18 ,  G01N33/53 ,  G01N33/569

摘要： In some aspects, the invention relates to methods for determining the proportion of intact, hypermutated, deleted, and/or defective proviruses in a sample of nucleic acids, e.g., a sample obtained from a subject. The subject may be a human subject. The virus may be HIV.

公开(公告)号：US20180214473A1

公开(公告)日：2018-08-02

申请号：US15568893

申请日：2016-04-22

申请人： The Johns Hopkins University

发明人： Katherine Bruner ,  Robert Siliciano

IPC分类号： A61K31/711 ,  A61P31/18 ,  G01N33/53 ,  G01N33/569

摘要： In some aspects, the invention relates to methods for determining the proportion of intact, hypermutated, deleted, and/or defective proviruses in a sample of nucleic acids, e.g., a sample obtained from a subject. The subject may be a human subject. The virus may be HIV.

公开(公告)号：US11180758B2

公开(公告)日：2021-11-23

申请号：US16078760

申请日：2017-02-24

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： David Lee Thomas ,  Ashwin Balagopal ,  Ramy El-Diwany ,  Robert Siliciano ,  Joel Blankson ,  Stuart C Ray ,  Michel Anand Chattergoon ,  Justin Bailey

IPC分类号： C12N15/12 ,  A61K38/00 ,  C12N15/113 ,  A61K38/45 ,  A61K38/17 ,  A61P31/18

摘要： Three proteins, BCL-G (BCL2L14), CMPK2, and LAMP3, were discovered to independently restrict HIV-1 replication both in-vivo and in-vitro. Methods are described wherein subjects are given an effective amount of a pharmaceutical composition comprising a protein selected from the group consisting of BCL-G, CMPK2, LAMP3, functional parts thereof, recombinant proteins thereof, and combinations thereof, for the purpose of treating or preventing HIV.

公开(公告)号：US20170360920A1

公开(公告)日：2017-12-21

申请号：US15528230

申请日：2015-11-20

申请人： The Johns Hopkins University

发明人： Robert Siliciano ,  Kai Deng ,  Liang Shan

IPC分类号： A61K39/21 ,  C12N7/00 ,  A61K39/00

CPC分类号： A61K39/21 ,  A61K39/12 ,  A61K2039/5158 ,  A61K2039/545 ,  A61K2039/572 ,  C12N7/00 ,  C12N2740/16034 ,  C12N2740/16134 ,  C12N2740/16171 ,  C12N2740/16234 ,  C12N2740/16271

摘要： Described herein are methods of preventing or treating a HIV infection comprising administering to a mammal in need thereof, a pharmaceutically effective amount of a CD8+ T cell vaccine composition. Such methods comprising using CD8+ T cells which have been pre-stimulated with at least one HIV epitope, to thereby enhance a CD8+ T cell immune response against HIV in said mammal.