公开(公告)号：US11834401B2

公开(公告)日：2023-12-05

申请号：US16921318

申请日：2020-07-06

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： Douglas Robinson ,  Alexandra Surcel ,  Win Pin Ng ,  Caren L. Freel Meyers

IPC分类号： C07C49/825 ,  A61P35/00 ,  A61K31/12 ,  A61K31/136 ,  A61K31/15 ,  A61K31/27 ,  A61K45/06 ,  C07C271/58 ,  C07C275/30 ,  C12Q1/25 ,  C12Q1/02 ,  C07C251/80

CPC分类号： C07C49/825 ,  A61K31/12 ,  A61K31/136 ,  A61K31/15 ,  A61K31/27 ,  A61K45/06 ,  A61P35/00 ,  C07C251/80 ,  C07C271/58 ,  C07C275/30 ,  C12Q1/025 ,  G01N2333/44 ,  G01N2333/4712 ,  G01N2500/10 ,  A61K31/136 ,  A61K2300/00 ,  A61K31/12 ,  A61K2300/00 ,  A61K31/15 ,  A61K2300/00 ,  A61K31/27 ,  A61K2300/00

摘要： Described are methods of treating or preventing a disease in a subject treatable by modulating cell mechanics. The method includes administering to a subject having or at risk for such a disease a pharmaceutical composition. comprising an agent selected from the group comprising a salt, solvate, or stereoisomer of compound (VIII) or its derivatives or a mixture of their constituents, where the compound has the formula:

公开(公告)号：US10787410B2

公开(公告)日：2020-09-29

申请号：US15946849

申请日：2018-04-06

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： Douglas Robinson ,  Alexandra Surcel ,  Win Pin Ng ,  Caren L. Freel Meyers

IPC分类号： A61K45/06 ,  A61K31/136 ,  A61K31/27 ,  A61K31/12 ,  A61K31/15 ,  A61P35/00 ,  C07C49/825 ,  C07C271/58 ,  C07C251/80 ,  C12Q1/02 ,  C07C275/30

摘要： Described are methods of treating or preventing a disease in a subject treatable by modulating cell mechanics. The method includes administering to a subject having or at risk for such a disease a pharmaceutical composition comprising an agent selected from the group comprising a salt, solvate, or stereoisomer of compound (VIII) or its derivatives or a mixture of their constituents, where the compound has the formula:

公开(公告)号：US20190062248A1

公开(公告)日：2019-02-28

申请号：US15946849

申请日：2018-04-06

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： Douglas Robinson ,  Alexandra Surcel ,  Win Pin Ng ,  Caren L. Freel Meyers

IPC分类号： C07C49/825 ,  A61K45/06 ,  A61K31/136 ,  A61P35/00 ,  C12Q1/02 ,  C07C271/58 ,  A61K31/27 ,  A61K31/12 ,  C07C251/80 ,  A61K31/15

摘要： Described are methods of treating or preventing a disease in a subject treatable by modulating cell mechanics. The method includes administering to a subject having or at risk for such a disease a pharmaceutical composition. comprising an agent selected from the group comprising a salt, solvate, or stereoisomer of compound (VIII) or its derivatives or a mixture of their constituents, where the compound has the formula: