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公开(公告)号：US11959096B2
公开(公告)日：2024-04-16
申请号：US17025057
申请日：2020-09-18
IPC分类号： C12N5/00 , A61K35/545 , C12N5/0735 , C12N5/074 , C12N5/077
CPC分类号： C12N5/0081 , A61K35/545 , C12N5/0606 , C12N5/0657 , C12N5/0696 , C12N2500/38 , C12N2501/72 , C12N2501/724 , C12N2506/45
摘要： Provided herein are methods of reducing or eliminating undifferentiated pluripotent stem cells, where the methods comprise contacting an effective amount of a compound to a heterogeneous cell population or sample comprising or suspected of comprising differentiated cell types and undifferentiated pluripotent stem cells, whereby the contacting selectively reduces or eliminates undifferentiated pluripotent stem cells from the cell population or sample. Also provided are methods for obtaining a population of stem cell-derived cell types substantially free of undifferentiated pluripotent stem cells as well as isolated populations of such of stem cell-derived cell types.
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公开(公告)号：US20160340642A1
公开(公告)日：2016-11-24
申请号：US15112923
申请日：2015-01-21
IPC分类号： C12N5/00 , A61K35/545 , C12N5/074 , C12N5/077 , C12N5/0735
CPC分类号： C12N5/0081 , A61K35/545 , C12N5/0606 , C12N5/0657 , C12N5/0696 , C12N2500/38 , C12N2501/72 , C12N2501/724 , C12N2506/45
摘要： Provided herein are methods of reducing or eliminating undifferentiated pluripotent stem cells, where the methods comprise contacting an effective amount of a compound to a heterogeneous cell population or sample comprising or suspected of comprising differentiated cell types and undifferentiated pluripotent stem cells, whereby the contacting selectively reduces or eliminates undifferentiated pluripotent stem cells from the cell population or sample. Also provided are methods for obtaining a population of stem cell-derived cell types substantially free of undifferentiated pluripotent stem cells as well as isolated populations of such of stem cell-derived cell types.
摘要翻译： 本文提供了减少或消除未分化多能干细胞的方法，其中所述方法包括将有效量的化合物与包含或怀疑包含分化细胞类型和未分化多能干细胞的异质细胞群体或样品接触，由此接触选择性地降低 或从细胞群或样品中消除未分化的多能干细胞。 还提供了获得基本上不含未分化多能干细胞的干细胞来源的细胞类型群以及来自干细胞衍生的细胞类型的分离群体的方法。
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公开(公告)号：US20210017489A1
公开(公告)日：2021-01-21
申请号：US17025057
申请日：2020-09-18
IPC分类号： C12N5/00 , C12N5/0735 , C12N5/074 , A61K35/545 , C12N5/077
摘要： Provided herein are methods of reducing or eliminating undifferentiated pluripotent stem cells, where the methods comprise contacting an effective amount of a compound to a heterogeneous cell population or sample comprising or suspected of comprising differentiated cell types and undifferentiated pluripotent stem cells, whereby the contacting selectively reduces or eliminates undifferentiated pluripotent stem cells from the cell population or sample. Also provided are methods for obtaining a population of stem cell-derived cell types substantially free of undifferentiated pluripotent stem cells as well as isolated populations of such of stem cell-derived cell types.
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公开(公告)号：US10808222B2
公开(公告)日：2020-10-20
申请号：US16414025
申请日：2019-05-16
IPC分类号： C12N5/00 , C12N5/02 , C12N5/0735 , C12N5/074 , A61K35/545 , C12N5/077
摘要： Provided herein are methods of reducing or eliminating undifferentiated pluripotent stem cells, where the methods comprise contacting an effective amount of a compound to a heterogeneous cell population or sample comprising or suspected of comprising differentiated cell types and undifferentiated pluripotent stem cells, whereby the contacting selectively reduces or eliminates undifferentiated pluripotent stem cells from the cell population or sample. Also provided are methods for obtaining a population of stem cell-derived cell types substantially free of undifferentiated pluripotent stem cells as well as isolated populations of such of stem cell-derived cell types.
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公开(公告)号：US20190300847A1
公开(公告)日：2019-10-03
申请号：US16414025
申请日：2019-05-16
IPC分类号： C12N5/00 , A61K35/545 , C12N5/074 , C12N5/0735 , C12N5/077
摘要： Provided herein are methods of reducing or eliminating undifferentiated pluripotent stem cells, where the methods comprise contacting an effective amount of a compound to a heterogeneous cell population or sample comprising or suspected of comprising differentiated cell types and undifferentiated pluripotent stem cells, whereby the contacting selectively reduces or eliminates undifferentiated pluripotent stem cells from the cell population or sample. Also provided are methods for obtaining a population of stem cell-derived cell types substantially free of undifferentiated pluripotent stem cells as well as isolated populations of such of stem cell-derived cell types.
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公开(公告)号：US20230280344A1
公开(公告)日：2023-09-07
申请号：US18005802
申请日：2021-07-15
IPC分类号： G01N33/574
CPC分类号： G01N33/57407 , G01N2333/70596
摘要： The present invention provides methods and kits for detecting and treating multiple myeloma. The methods involve detecting proteins that the inventors have identified as biomarkers of multiple melanoma.
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公开(公告)号：US10316287B2
公开(公告)日：2019-06-11
申请号：US15112923
申请日：2015-01-21
IPC分类号： C12N5/00 , C12N5/02 , C12N5/0735 , C12N5/074 , A61K35/545 , C12N5/077
摘要： Provided herein are methods of reducing or eliminating undifferentiated pluripotent stem cells, where the methods comprise contacting an effective amount of a compound to a heterogeneous cell population or sample comprising or suspected of comprising differentiated cell types and undifferentiated pluripotent stem cells, whereby the contacting selectively reduces or eliminates undifferentiated pluripotent stem cells from the cell population or sample. Also provided are methods for obtaining a population of stem cell-derived cell types substantially free of undifferentiated pluripotent stem cells as well as isolated populations of such of stem cell-derived cell types.
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