公开(公告)号：US20240325771A1

公开(公告)日：2024-10-03

申请号：US18699264

申请日：2022-10-05

申请人： THE METHODIST HOSPITAL

发明人： Santosh A. Helekar ,  David Stuart Baskin ,  Martyn Alun Shape ,  Kumar Pichumani

IPC分类号： A61N2/00 ,  A61N2/12

CPC分类号： A61N2/004 ,  A61N2/12

摘要： A method for disrupting mitochondrial function in cells includes causing one or more magnets to oscillate along at least a first axis of rotation and a second axis of rotation substantially orthogonal to the first axis of rotation, so as to generate an oscillating magnetic field. To this end, the method includes selecting the first axis of rotation, applying an oscillation pattern along the first axis of rotation, the oscillating including a ramp-up period for an oscillation frequency, a ramp-down period for the oscillation frequency, and an inactive period following the ramp-down period, selecting the second axis of rotation, and applying the oscillation pattern along the second axis of rotation. The method further includes applying the oscillating magnetic field to a tissue comprising cancer cells to trigger apoptosis in the cancer cells.