公开(公告)号：US20240003858A1

公开(公告)日：2024-01-04

申请号：US18250911

申请日：2021-10-29

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Michael R. Van Dam ,  Travis S. Holloway ,  Alejandra Rios ,  Chelsea Okoro

IPC: G01N30/95 ,  B01J20/28 ,  B01J20/34 ,  B01D15/42

CPC classification number: G01N30/95 ,  B01J20/28035 ,  B01J20/3475 ,  B01D15/426 ,  B01J2220/52 ,  B01J2220/49

Abstract: A method of purifying radiochemical species (e.g., radiopharmaceuticals) using thin layer chromatography (TLC) plates includes loading one or more TLC plates with a sample containing the radiochemical species to be purified. The one or more TLC plates are then developed with a mobile phase. The one or more developed TLC plates are then imaged to obtain radioactivity image(s) of the one or more TLC plates. Optional UV images may also be obtained using the same imaging platform. The location of the radiochemical species on the one or more TLC plates is identified from the radioactivity image(s). The radiochemical species on the one or more TLC plates is/are removed at the identified locations. Removal may be accomplished using a mechanical process such as scraping or punching. Alternatively, non-destructive techniques may be employed to remove the radiochemical species from the TLC plate(s).