公开(公告)号：US20210196863A1

公开(公告)日：2021-07-01

申请号：US16075100

申请日：2017-02-01

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Tatiana Segura ,  Lina R. Nih ,  Elias Sideris

IPC: A61L27/52 ,  A61L27/20 ,  A61L27/54 ,  A61L27/58

Abstract: A hydrogel material for the treatment of stroke or other brain injury includes a collection of hyaluronic acid-based microgel particles comprising one or more network crosslinker components, wherein the hyaluronic acid-based microgel particles, when exposed to an endogenous annealing agent (e.g., Factor XIIIa), links the hyaluronic acid-based microgel particles together in situ to form a covalently-stabilized scaffold of microgel particles having interstitial spaces therein. The hydrogel material may be injected into a stroke cavity and was shown to promote brain tissue repair by promoting the recruitment of neural stem cells to the injured site and reducing the post-stroke inflammatory response.