公开(公告)号：US20240416008A1

公开(公告)日：2024-12-19

申请号：US18443314

申请日：2024-02-16

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Dino Di Carlo ,  Westbrook Weaver ,  Tatiana Segura ,  Jaekyung Koh ,  Philip Scumpia ,  Donald R. Griffin

IPC: A61L27/52 ,  A61K9/00 ,  A61K9/16 ,  A61K39/00 ,  A61K39/39 ,  A61L27/54 ,  A61L27/56 ,  C08H1/00

Abstract: A hydrogel material for use in a human subject or other mammal includes a collection of microgel particles having one or more network cross linker components, wherein the microgel particles, when exposed to an endogenous or exogenous annealing agent, links the microgel particles together in situ to form a covalently-stabilized scaffold of microgel particles having pores formed between the microgel particles wherein the pores are substantially devoid of hydrogel.

公开(公告)号：US20210196863A1

公开(公告)日：2021-07-01

申请号：US16075100

申请日：2017-02-01

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Tatiana Segura ,  Lina R. Nih ,  Elias Sideris

IPC: A61L27/52 ,  A61L27/20 ,  A61L27/54 ,  A61L27/58

Abstract: A hydrogel material for the treatment of stroke or other brain injury includes a collection of hyaluronic acid-based microgel particles comprising one or more network crosslinker components, wherein the hyaluronic acid-based microgel particles, when exposed to an endogenous annealing agent (e.g., Factor XIIIa), links the hyaluronic acid-based microgel particles together in situ to form a covalently-stabilized scaffold of microgel particles having interstitial spaces therein. The hydrogel material may be injected into a stroke cavity and was shown to promote brain tissue repair by promoting the recruitment of neural stem cells to the injured site and reducing the post-stroke inflammatory response.

公开(公告)号：US20190142965A1

公开(公告)日：2019-05-16

申请号：US16092202

申请日：2017-04-10

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Tatiana Segura ,  Donald Griffin ,  Philip Scumpia

IPC: A61K47/69 ,  A61K47/60 ,  A61P17/02 ,  A61K39/39 ,  A61K38/06 ,  A61K38/48 ,  A61K39/00 ,  A61K39/02 ,  A61K39/12

Abstract: An immune-modulating biomaterial comprising a hydrogel scaffold coupled to D-amino acid containing peptides having unexpected properties in vivo is described. For example, certain inflammatory reactions in vivo are significantly increased around the D-peptide containing particles of hydrogel scaffold as compared to particles that contain both L and D peptides or L peptides alone. In addition, these D-peptide compositions are further observed to enhance wound healing and improve the tensile strength of healed tissues. For these and other reasons, the D-amino acid hydrogel materials disclosed herein are useful in a number of methodologies that seek to modulate the immune response and/or wound healing.

公开(公告)号：US11464886B2

公开(公告)日：2022-10-11

申请号：US17144158

申请日：2021-01-08

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Donald R. Griffin ,  Westbrook Weaver ,  Tatiana Segura ,  Dino Di Carlo ,  Philip Scumpia

IPC: A61L26/00 ,  A61L27/18 ,  A61L27/58 ,  A61K47/62 ,  A61K9/06 ,  A61K31/795 ,  A61L27/22 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56

Abstract: A microporous gel system for certain applications, including biomedical applications, includes an aqueous solution containing plurality of microgel particles including a biodegradable crosslinker. In some aspects, the microgel particles act as gel building blocks that anneal to one another to form a covalently-stabilized scaffold of microgel particles having interstitial spaces therein. In certain aspects, annealing of the microgel particles occurs after exposure to an annealing agent that is endogenously present or exogenously added. In some embodiments, annealing of the microgel particles requires the presence of an initiator such as exposure to light. In particular embodiments, the chemical and physical properties of the gel building blocks can be controlled to allow downstream control of the resulting assembled scaffold. In one or more embodiments, cells are able to quickly infiltrate the interstitial spaces of the assembled scaffold.

公开(公告)号：US10849988B2

公开(公告)日：2020-12-01

申请号：US16092202

申请日：2017-04-10

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Tatiana Segura ,  Donald Griffin ,  Philip Scumpia

IPC: A61K38/00 ,  A61K39/00 ,  A61K39/12 ,  A61K47/69 ,  A61K39/39 ,  A61L27/38 ,  A61L27/18 ,  A61L27/54 ,  A61L27/58 ,  A61L27/50 ,  A61L26/00 ,  A61L27/20 ,  A61L27/52 ,  A61L27/56 ,  A61K47/60 ,  A61P17/02 ,  A61K38/06 ,  A61K38/48 ,  A61K39/02

Abstract: An immune-modulating biomaterial comprising a hydrogel scaffold coupled to D-amino acid containing peptides having unexpected properties in vivo is described. For example, certain inflammatory reactions in vivo are significantly increased around the D-peptide containing particles of hydrogel scaffold as compared to particles that contain both L and D peptides or L peptides alone. In addition, these D-peptide compositions are further observed to enhance wound healing and improve the tensile strength of healed tissues. For these and other reasons, the D-amino acid hydrogel materials disclosed herein are useful in a number of methodologies that seek to modulate the immune response and/or wound healing.

公开(公告)号：US20190388583A1

公开(公告)日：2019-12-26

申请号：US16480864

申请日：2018-01-30

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Tatiana Segura ,  Nicolas Bernthal ,  Weixian Xi

IPC: A61L27/34 ,  A61L27/54 ,  C08G75/045

Abstract: A copolymer poly(ethylene glycol)-polyallyl mercaptan (PEG-PAM) material is used as a drug-containing coating for medical implants. In one embodiment, a mixture of multi-arm poly(ethylene glycol) (PEG), polyallyl mercaptan (PAM), a photoinitiator, organic solvent, and one or more drugs, medicaments, or pharmaceutical compounds is applied to a surface of the implant and is exposed to a polymerizing light source to form a PEG-PAM material coating that is formed in situ on the implant. The PEG-PAM coating may be used by surgeons to incorporate antibacterial drugs or the like into coatings that are applied in the operating room setting to medical devices such as orthopedic implants. The type of drug and dosing can be customized during the coating operation and tailored to the patient's needs. PEG-PAM may also be applied as a coating on or within tissue or an injectable gel.

公开(公告)号：US10201613B2

公开(公告)日：2019-02-12

申请号：US14426259

申请日：2013-08-20

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Heather D. Maynard ,  Tatiana Segura ,  Gregory Grover ,  Jonathan Lam

IPC: A61K47/42 ,  A61K9/00 ,  A61K9/06 ,  A61K35/545 ,  C08G65/48 ,  C08J3/075 ,  C08J3/24 ,  C08L101/02 ,  C08L101/06 ,  C08G65/333 ,  C08G65/337

Abstract: A method of creating a hydrogel, comprising the step of condensing first and second functional groups, wherein the first group comprises a molecule or macromolecule of interest containing two or more hydroxylamine or aminooxy groups and the second group comprises a molecule or macromolecule of interest containing two or more aldehyde/ketone/other reactive oxo groups, under conditions such that a hydrogel forms.

公开(公告)号：US20170368224A1

公开(公告)日：2017-12-28

申请号：US15701113

申请日：2017-09-11

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Donald R. Griffin ,  Westbrook Weaver ,  Tatiana Segura ,  Dino Di Carlo ,  Philip Scumpia

IPC: A61L26/00 ,  A61L27/52 ,  A61L27/56 ,  A61L27/54 ,  A61L27/22

CPC classification number: A61L26/008 ,  A61L26/0019 ,  A61L26/0047 ,  A61L26/0066 ,  A61L26/0085 ,  A61L26/009 ,  A61L27/18 ,  A61L27/227 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L2300/252 ,  A61L2300/412 ,  A61L2400/06 ,  A61L2430/00 ,  A61L2430/34 ,  C08L71/02

Abstract: A microporous gel system for certain applications, including biomedical applications, includes an aqueous solution containing plurality of microgel particles including a biodegradable crosslinker. In some aspects, the microgel particles act as gel building blocks that anneal to one another to form a covalently-stabilized scaffold of microgel particles having interstitial spaces therein. In certain aspects, annealing of the microgel particles occurs after exposure to an annealing agent that is endogenously present or exogenously added. In some embodiments, annealing of the microgel particles requires the presence of an initiator such as exposure to light. In particular embodiments, the chemical and physical properties of the gel building blocks can be controlled to allow downstream control of the resulting assembled scaffold. In one or more embodiments, cells are able to quickly infiltrate the interstitial spaces of the assembled scaffold.

公开(公告)号：US11931480B2

公开(公告)日：2024-03-19

申请号：US16077985

申请日：2017-02-14

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Dino Di Carlo ,  Westbrook Weaver ,  Tatiana Segura ,  Philip Scumpia ,  Donald R. Griffin

IPC: A61L27/52 ,  A61K9/00 ,  A61K9/16 ,  A61K39/39 ,  A61L27/54 ,  A61L27/56 ,  C08H1/00 ,  A61K39/00

CPC classification number: A61L27/52 ,  A61K9/0019 ,  A61K9/1635 ,  A61K9/1641 ,  A61K9/1652 ,  A61K39/39 ,  A61L27/54 ,  A61L27/56 ,  C08H1/00 ,  A61K2039/60 ,  A61K2039/6093 ,  A61L2300/426 ,  A61L2300/64 ,  A61L2400/06

Abstract: A hydrogel material for modulating an immune response in a human subject or other mammal includes a collection of microgel particles having one or more network cross linker components, wherein the microgel particles, when exposed to an endogenous or exogenous annealing agent, links the microgel particles together in situ to form a covalently-stabilized scaffold of microgel particles having interstitial spaces formed between the microgel particles and wherein the collection of microgel particles further includes at least one of an antigen and an adjuvant.

公开(公告)号：US20230081945A1

公开(公告)日：2023-03-16

申请号：US17904553

申请日：2021-02-24

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Nicholas Bernthal ,  Weixian Xi ,  Tatiana Segura

IPC: A61L31/10 ,  A61L31/16 ,  A61L31/14 ,  B05D3/06 ,  B05D7/16

Abstract: A polymeric medical device/implant coating is disclosed for the delivery of drugs or therapeutic compounds such as antibiotics over an extended period of time and at levels or concentrations that exceed the MIC. In one embodiment, an antibiotic such as vancomycin is encapsulated in a photo-crosslinked poly(lactide-co-glycolide) (PLGA)-dimethacrylate coating. The drug release profile of this coating was studied and the initial burst was reduced by photo-crosslinking. Due to photo-crosslinking, an additional diffusional resistance was created, which prevented easy diffusion of the drug into the release medium. Moreover, the time required for this coating process is very quick (e.g., around 5 minutes) and makes it compatible for this coating to be applied in the operating room.