公开(公告)号：US20210196863A1

公开(公告)日：2021-07-01

申请号：US16075100

申请日：2017-02-01

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Tatiana Segura ,  Lina R. Nih ,  Elias Sideris

IPC: A61L27/52 ,  A61L27/20 ,  A61L27/54 ,  A61L27/58

Abstract: A hydrogel material for the treatment of stroke or other brain injury includes a collection of hyaluronic acid-based microgel particles comprising one or more network crosslinker components, wherein the hyaluronic acid-based microgel particles, when exposed to an endogenous annealing agent (e.g., Factor XIIIa), links the hyaluronic acid-based microgel particles together in situ to form a covalently-stabilized scaffold of microgel particles having interstitial spaces therein. The hydrogel material may be injected into a stroke cavity and was shown to promote brain tissue repair by promoting the recruitment of neural stem cells to the injured site and reducing the post-stroke inflammatory response.

公开(公告)号：US20210220388A1

公开(公告)日：2021-07-22

申请号：US17054421

申请日：2018-05-10

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Tatiana Segura ,  Stanley Thomas Carmichael ,  Lina R. Nih

IPC: A61K31/727 ,  A61K9/14 ,  A61K9/06 ,  A61K47/36 ,  A61K47/18 ,  A61K47/42 ,  A61P9/10

Abstract: A therapeutic hydrogel material includes a hyaluronic acid-based hydrogel matrix containing naked heparin nanoparticles distributed and entrained within the matrix. The naked heparin nanoparticles contained in the matrix are not immobilized to any other molecules at the time of delivery. In one aspect of the invention, the therapeutic hydrogel material is used to repair ischemic tissue in a subject (e.g., mammal). The therapeutic hydrogel material may also be used to treat wounds or other damaged tissue. To treat the subject or patient, the site of application is located and the therapeutic hydrogel material is injected or otherwise delivered (with or without a delivery device) to the delivery location along with a crosslinker.