公开(公告)号：US20230145782A1

公开(公告)日：2023-05-11

申请号：US17772948

申请日：2020-10-29

申请人： The Regents of the University of California

发明人： Kevan Shokat ,  Keelan Guiley

IPC分类号： C07D495/14 ,  C07D487/04 ,  C07D498/04 ,  C07D413/14 ,  C07J43/00 ,  C07D209/86 ,  C07D209/88 ,  C07D209/42 ,  C07D403/04

CPC分类号： C07D495/14 ,  C07D487/04 ,  C07D498/04 ,  C07D413/14 ,  C07J43/003 ,  C07D209/86 ,  C07D209/88 ,  C07D209/42 ,  C07D403/04

摘要： Described herein, inter alia, are p53 modulator compounds and methods of using the same. In an aspect is provided a p53 protein covalently bonded to a compound described herein. In an aspect is provided a pharmaceutical composition including a compound described herein and a pharmaceutically acceptable excipient. In an aspect is provided a method of treating cancer in a subject in need of such treatment, including administering to the subject an effective amount of a compound described herein.

公开(公告)号：US11692179B2

公开(公告)日：2023-07-04

申请号：US16977441

申请日：2019-04-10

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Seth Rubin ,  Keelan Guiley

IPC分类号： C12N9/12 ,  C07K14/47 ,  C12Q1/48

CPC分类号： C12N9/12 ,  C07K14/4738 ,  C12Q1/485 ,  C12Y207/11022 ,  G01N2440/14 ,  G01N2500/02

摘要： The disclosure provides polypeptides comprising an engineered p27, or a fragment thereof. Such polypeptides may be used to form trimeric protein complexes with a cyclin-dependent kinase 4 (Cdk4) (or a variant thereof) or Cdk6 (or a variant thereof), and a cyclin D (CycD) or a variant thereof.