公开(公告)号：US20230081945A1

公开(公告)日：2023-03-16

申请号：US17904553

申请日：2021-02-24

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Nicholas Bernthal ,  Weixian Xi ,  Tatiana Segura

IPC: A61L31/10 ,  A61L31/16 ,  A61L31/14 ,  B05D3/06 ,  B05D7/16

Abstract: A polymeric medical device/implant coating is disclosed for the delivery of drugs or therapeutic compounds such as antibiotics over an extended period of time and at levels or concentrations that exceed the MIC. In one embodiment, an antibiotic such as vancomycin is encapsulated in a photo-crosslinked poly(lactide-co-glycolide) (PLGA)-dimethacrylate coating. The drug release profile of this coating was studied and the initial burst was reduced by photo-crosslinking. Due to photo-crosslinking, an additional diffusional resistance was created, which prevented easy diffusion of the drug into the release medium. Moreover, the time required for this coating process is very quick (e.g., around 5 minutes) and makes it compatible for this coating to be applied in the operating room.