公开(公告)号：US20190388583A1

公开(公告)日：2019-12-26

申请号：US16480864

申请日：2018-01-30

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Tatiana Segura ,  Nicolas Bernthal ,  Weixian Xi

IPC: A61L27/34 ,  A61L27/54 ,  C08G75/045

Abstract: A copolymer poly(ethylene glycol)-polyallyl mercaptan (PEG-PAM) material is used as a drug-containing coating for medical implants. In one embodiment, a mixture of multi-arm poly(ethylene glycol) (PEG), polyallyl mercaptan (PAM), a photoinitiator, organic solvent, and one or more drugs, medicaments, or pharmaceutical compounds is applied to a surface of the implant and is exposed to a polymerizing light source to form a PEG-PAM material coating that is formed in situ on the implant. The PEG-PAM coating may be used by surgeons to incorporate antibacterial drugs or the like into coatings that are applied in the operating room setting to medical devices such as orthopedic implants. The type of drug and dosing can be customized during the coating operation and tailored to the patient's needs. PEG-PAM may also be applied as a coating on or within tissue or an injectable gel.

公开(公告)号：US20230081945A1

公开(公告)日：2023-03-16

申请号：US17904553

申请日：2021-02-24

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Nicholas Bernthal ,  Weixian Xi ,  Tatiana Segura

IPC: A61L31/10 ,  A61L31/16 ,  A61L31/14 ,  B05D3/06 ,  B05D7/16

Abstract: A polymeric medical device/implant coating is disclosed for the delivery of drugs or therapeutic compounds such as antibiotics over an extended period of time and at levels or concentrations that exceed the MIC. In one embodiment, an antibiotic such as vancomycin is encapsulated in a photo-crosslinked poly(lactide-co-glycolide) (PLGA)-dimethacrylate coating. The drug release profile of this coating was studied and the initial burst was reduced by photo-crosslinking. Due to photo-crosslinking, an additional diffusional resistance was created, which prevented easy diffusion of the drug into the release medium. Moreover, the time required for this coating process is very quick (e.g., around 5 minutes) and makes it compatible for this coating to be applied in the operating room.

公开(公告)号：US12208178B2

公开(公告)日：2025-01-28

申请号：US16480864

申请日：2018-01-30

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Tatiana Segura ,  Nicolas Bernthal ,  Weixian Xi

IPC: A61L27/34 ,  A61L27/54 ,  C08G75/045

Abstract: A copolymer poly(ethylene glycol)-polyallyl mercaptan (PEG-PAM) material is used as a drug-containing coating for medical implants. In one embodiment, a mixture of multi-arm poly(ethylene glycol) (PEG), polyallyl mercaptan (PAM), a photoinitiator, organic solvent, and one or more drugs, medicaments, or pharmaceutical compounds is applied to a surface of the implant and is exposed to a polymerizing light source to form a PEG-PAM material coating that is formed in situ on the implant. The PEG-PAM coating may be used by surgeons to incorporate antibacterial drugs or the like into coatings that are applied in the operating room setting to medical devices such as orthopedic implants. The type of drug and dosing can be customized during the coating operation and tailored to the patient's needs. PEG-PAM may also be applied as a coating on or within tissue or an injectable gel.