公开(公告)号：US20250154510A1

公开(公告)日：2025-05-15

申请号：US18949317

申请日：2024-11-15

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Thomas G. GRAEBER ,  Chia-Chin CHEN ,  Owen WITTE ,  Jung Wook PARK

IPC: C12N15/113 ,  A61K45/06 ,  A61N5/10

Abstract: The current disclosure is centered on the hypothesis that a better understanding of the neuroendocrine transdifferentiation (NEtD) process will provide therapeutic targets for inhibiting this transition and thus improving standard of care therapies. Accordingly, the current disclosure provides for a method for treating cancer in a subject, the method comprising administering an inhibitor of a gene, wherein the gene comprises one or more of tenascin C (TNC), advillin (AVIL), S100A7, PPARG, LOX lysyl oxidase, KLF5, APOBEC2, FOSL1, FOXM1, hedgehog, RELA, p65, IKK complex, JAK, STAT, TFAP4, geminin, OCA-1, OCA-2, Nf-kB, Nf-kB family and associated regulators, angiogenesis regulators such as BMX kinase, TEK kinase, periostin (POSTN), and VEGF family, stress genes, such as the JUN/FOS family, a gene from the S100 family, and cell state regulators such as ASCL1, POU2F3, NEUROD1, ASCL2, and YAP1.

公开(公告)号：US20240182518A1

公开(公告)日：2024-06-06

申请号：US17760479

申请日：2021-02-12

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Yi XING ,  Owen WITTE ,  John PHILLIPS ,  Yang PAN

IPC: C07K7/02 ,  A61K39/00

CPC classification number: C07K7/02 ,  A61K39/00 ,  C07K2319/40 ,  C07K2319/92

Abstract: Methods and processes to identify neoplastic tissue antigens derived from alternative splicing (AS) are described, in accordance with various embodiments of the invention. Also described are novel tumor antigens that are useful as targets in various immunotherapeutic approaches to treating cancer as well as novel engineered T cell Receptors (TCRs) and chimeric antigen receptors (CARs) that target these antigenic peptides.