公开(公告)号：US20220380937A1

公开(公告)日：2022-12-01

申请号：US17775198

申请日：2020-11-06

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Yi XING ,  Robert PRINS ,  Yang PAN ,  Alexander H. LEE

IPC: C40B40/08 ,  A61K35/15 ,  A61K35/17 ,  A61K35/28 ,  A61K35/545 ,  C07K14/725 ,  G16B30/10

Abstract: Methods and processes to identify neoplastic tissue antigens derived from alternative splicing (AS) are described, in accordance with various embodiments of the invention. Also described are novel tumor antigens that are useful as targets in various immunotherapeutic approaches to treating brain cancer as well as novel engineered T cell Receptors (TCRs) and chimeric antigen receptors (CARs) that target these antigenic peptides.

公开(公告)号：US20240182518A1

公开(公告)日：2024-06-06

申请号：US17760479

申请日：2021-02-12

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Yi XING ,  Owen WITTE ,  John PHILLIPS ,  Yang PAN

IPC: C07K7/02 ,  A61K39/00

CPC classification number: C07K7/02 ,  A61K39/00 ,  C07K2319/40 ,  C07K2319/92

Abstract: Methods and processes to identify neoplastic tissue antigens derived from alternative splicing (AS) are described, in accordance with various embodiments of the invention. Also described are novel tumor antigens that are useful as targets in various immunotherapeutic approaches to treating cancer as well as novel engineered T cell Receptors (TCRs) and chimeric antigen receptors (CARs) that target these antigenic peptides.