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公开(公告)号：US10588867B2
公开(公告)日：2020-03-17
申请号：US16515906
申请日：2019-07-18
Applicant: The Regents of the University of California
Inventor： Liangfang Zhang , Weiwei Gao , Ronnie H. Fang , Che-Ming Jack Hu
IPC: A61K39/00 , A61K9/51 , A61K39/02 , A61K9/50 , A61K31/427 , A61K31/43 , A61K31/49 , A61K31/545 , A61K45/06 , B82Y5/00
Abstract: Nanoparticles are provided comprising an inner core comprising a non-cellular material, and an outer surface comprising a bacterial membrane, e.g., a bacterial membrane derived from a bacteria outer membrane vesicle. Also provided are compositions, e.g., medicament delivery systems and pharmaceutical compositions, comprising the present nanoparticles. Also provided are uses of the present nanoparticles, pharmaceutical compositions and medicament delivery systems for treating and/or preventing a disease or condition, e.g., bacterial infection, in a subject.
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公开(公告)号：US20180085320A1
公开(公告)日：2018-03-29
申请号：US15558636
申请日：2016-03-18
Applicant: The Regents of the University of California
Inventor： Liangfang Zhang , Weiwei Gao , Ronnie H. Fang , Che-Ming Jack Hu
CPC classification number: A61K9/5176 , A61K9/5068 , A61K9/5192 , A61K31/427 , A61K31/43 , A61K31/49 , A61K31/545 , A61K39/02 , A61K45/06 , B82Y5/00 , Y02A50/401 , Y02A50/478 , Y02A50/48 , Y02A50/484 , A61K2300/00
Abstract: Nanoparticles are provided comprising an inner core comprising a non-cellular material, and an outer surface comprising a bacterial membrane, e.g., a bacterial membrane derived from a bacteria outer membrane vesicle. Also provided are compositions, e.g., medicament delivery systems and pharmaceutical compositions, comprising the present nanoparticles. Also provided are uses of the present nanoparticles, pharmaceutical compositions and medicament delivery systems for treating and/or preventing a disease or condition, e.g., bacterial infection, in a subject.
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公开(公告)号：US20180153821A1
公开(公告)日：2018-06-07
申请号：US15737566
申请日：2016-06-07
Applicant: The Regents of the University of California
Inventor： Liangfang Zhang , Che-Ming Jack Hu , Ronnie H. Fang , Brian T. Luk , Kuei-Chun Wang , Shu Chien
IPC: A61K9/51 , A61P7/04 , A61P9/00 , A61P35/00 , A61K31/337
CPC classification number: A61K9/5176 , A61K9/5153 , A61K9/5169 , A61K31/337 , A61K47/6901 , A61P7/04 , A61P9/00 , A61P35/00 , B82Y5/00 , B82Y30/00
Abstract: The present invention relates to prevention and/or treatment of diseases or disorders associated with a damaged or leaky vasculature in a subject. The present invention provides for methods, combinations and pharmaceutical compositions for preventing and/or treating a disease or disorder associated with a damaged or leaky vasculature in a subject, using, inter alia, an effective amount of a nanoparticle comprising an inner core comprising a non-cellular material, an outer surface comprising a cellular membrane derived from a platelet; and optionally an agent for preventing, treating, diagnosing, or prognosing the disease or disorder and/or monitoring prevention or treatment of the disease or disorder. Exemplary diseases or disorders include hemorrhage (bleeding), cardiovascular diseases or disorders, diseases or disorders associated with narrowing of a blood vessel, tumors or cancers.
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公开(公告)号：US20180140558A1
公开(公告)日：2018-05-24
申请号：US15568316
申请日：2016-04-13
Applicant: The Regents of the University of California
Inventor： Liangfang Zhang , Zhiqing Pang , Ronnie H. Fang , Che-Ming Jack Hu
CPC classification number: A61K9/5176 , A61K9/5068 , A61K45/06
Abstract: The present invention relates treatments of a toxin in a subject. The toxin at least partially effects its toxicity in the subject via binding to a target cell of the subject. The present invention provides for methods, combinations and pharmaceutical compositions for decreasing or neutralizing the effect of a toxin in a subject, using, inter alia, an effective amount of a nanoparticle comprising an inner core comprising a non-cellular material, and an outer surface comprising a cellular membrane derived from a source cell. Exemplary toxins include acetylcholinesterase (AChE) inhibitors such as organophosphate poisoning.
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公开(公告)号：US20220331365A1
公开(公告)日：2022-10-20
申请号：US17639895
申请日：2020-09-01
Applicant: The Regents of the University of California
Inventor： Liangfang Zhang , Ronnie H. Fang , Jia Zhuang , Weiwei Gao
Abstract: A biomimetic oxygen delivery carrier is provided by employing natural cell membrane as a stabilizer for fluorocarbon nanoemulsions. The resulting formulation exhibits a high capacity for delivering oxygen and can be used to successfully resuscitate subjects in need due to for example hemorrhagic shock. This natural-synthetic platform can alleviate the impact of blood shortages in clinical settings among other uses.
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Patent Agency Ranking
公开(公告)号：US20190358171A1
公开(公告)日：2019-11-28
申请号：US16515906
申请日：2019-07-18
Applicant: The Regents of the University of California
Inventor： Liangfang Zhang , Weiwei Gao , Ronnie H. Fang , Che-Ming Jack Hu
IPC: A61K9/51 , A61K31/545 , A61K31/49 , A61K31/43 , A61K31/427 , A61K39/02 , A61K9/50 , A61K45/06
Abstract: Nanoparticles are provided comprising an inner core comprising a non-cellular material, and an outer surface comprising a bacterial membrane, e.g., a bacterial membrane derived from a bacteria outer membrane vesicle. Also provided are compositions, e.g., medicament delivery systems and pharmaceutical compositions, comprising the present nanoparticles. Also provided are uses of the present nanoparticles, pharmaceutical compositions and medicament delivery systems for treating and/or preventing a disease or condition, e.g., bacterial infection, in a subject.
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公开(公告)号：US10383830B2
公开(公告)日：2019-08-20
申请号：US15558636
申请日：2016-03-18
Applicant: The Regents of the University of California
Inventor： Liangfang Zhang , Weiwei Gao , Ronnie H. Fang , Che-Ming Jack Hu
IPC: A61K39/00 , A61K9/51 , A61K45/06 , A61K31/427 , A61K31/43 , A61K31/49 , A61K31/545 , A61K9/50 , A61K39/02 , B82Y5/00
Abstract: Nanoparticles are provided comprising an inner core comprising a non-cellular material, and an outer surface comprising a bacterial membrane, e.g., a bacterial membrane derived from a bacteria outer membrane vesicle. Also provided are compositions, e.g., medicament delivery systems and pharmaceutical compositions, comprising the present nanoparticles. Also provided are uses of the present nanoparticles, pharmaceutical compositions and medicament delivery systems for treating and/or preventing a disease or condition, e.g., bacterial infection, in a subject.
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公开(公告)号：US12083162B2
公开(公告)日：2024-09-10
申请号：US17208228
申请日：2021-03-22
Applicant: The Regents of the University of California
Inventor： Liangfang Zhang , Weiwei Gao , Ronnie H. Fang
CPC classification number: A61K38/1796 , A61K9/127 , A61K47/6901
Abstract: A nanoparticle comprising an outer surface comprising a plasma membrane derived from a cell that can be infected with a respiratory virus, including a human lung epithelial cell expressing ACE-2 receptor. Methods of manufacture and use for preventing or treating viral infections, such as coronavirus infection in a subject in need are disclosed.
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公开(公告)号：US11357736B2
公开(公告)日：2022-06-14
申请号：US16779070
申请日：2020-01-31
Applicant: The Regents of the University of California
Inventor： Liangfang Zhang , Zhiqing Pang , Ronnie H. Fang , Che-Ming Jack Hu
Abstract: The present invention relates treatments of a toxin in a subject. The toxin at least partially effects its toxicity in the subject via binding to a target cell of the subject. The present invention provides for methods, combinations and pharmaceutical compositions for decreasing or neutralizing the effect of a toxin in a subject, using, inter alia, an effective amount of a nanoparticle comprising an inner core comprising a non-cellular material, and an outer surface comprising a cellular membrane derived from a source cell. Exemplary toxins include acetylcholinesterase (AChE) inhibitors such as organophosphate poisoning.
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公开(公告)号：US20210299217A1
公开(公告)日：2021-09-30
申请号：US17208228
申请日：2021-03-22
Applicant: The Regents of the University of California
Inventor： Liangfang Zhang , Weiwei Gao , Ronnie H. Fang
Abstract: A nanoparticle comprising an outer surface comprising a plasma membrane derived from a cell that can be infected with a respiratory virus, including a human lung epithelial cell expressing ACE-2 receptor. Methods of manufacture and use for preventing or treating viral infections, such as coronavirus infection in a subject in need are disclosed.
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