公开(公告)号：US20190055537A1

公开(公告)日：2019-02-21

申请号：US16178024

申请日：2018-11-01

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Richard Carrillo ,  Jan P. Kraus ,  Tomas Majtan ,  David Naveh

IPC: C12N9/88 ,  B01D15/38 ,  B01D15/36 ,  A61K38/51

Abstract: This invention provides chromatographic methods for the purification of a cystathionine β-Synthase (CBS) protein, particularly truncated variants thereof and compositions and pharmaceutical compositions prepared therefrom.

公开(公告)号：US09243239B2

公开(公告)日：2016-01-26

申请号：US13830494

申请日：2013-03-14

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Richard Carrillo ,  Jan P. Kraus ,  Tomas Majtan ,  David Naveh

IPC: C12N9/88

CPC classification number: C12N9/88 ,  A61K38/51 ,  B01D15/363 ,  B01D15/3823 ,  C12Y402/01022

Abstract: This invention provides chromatographic methods for the purification of a cystathionine β-Synthase (CBS) protein, particularly truncated variants thereof and compositions and pharmaceutical compositions prepared therefrom.

Abstract translation: 本发明提供了用于纯化胱硫醚和硫酸钠（CBS）蛋白质，特别是其截短的变体以及由其制备的组合物和药物组合物的色谱方法。

公开(公告)号：US10941392B2

公开(公告)日：2021-03-09

申请号：US16739169

申请日：2020-01-10

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Richard Carrillo ,  Jan P. Kraus ,  Tomas Majtan ,  David Naveh

IPC: C12N9/88 ,  A61K38/51 ,  B01D15/36 ,  B01D15/38

Abstract: This invention provides chromatographic methods for the purification of a cystathionine β-Synthase (CBS) protein, particularly truncated variants thereof and compositions and pharmaceutical compositions prepared therefrom.

公开(公告)号：US10160962B2

公开(公告)日：2018-12-25

申请号：US14970814

申请日：2015-12-16

Applicant: The Regents of the University of Colorado, a Body Corporate

Inventor： Richard Carrillo ,  Jan P. Kraus ,  Tomas Majtan ,  David Naveh

IPC: C12N9/88 ,  A61K38/51 ,  B01D15/36 ,  B01D15/38

Abstract: This invention provides chromatographic methods for the purification of a cystathionine β-Synthase (CBS) protein, particularly truncated variants thereof and compositions and pharmaceutical compositions prepared therefrom.