公开(公告)号：US09884841B2

公开(公告)日：2018-02-06

申请号：US15134098

申请日：2016-04-20

Applicant: The Regents of the University of Michigan

Inventor： Zaneta Nikolovska-Coleska ,  Jeanne A. Stuckey ,  Ahmed Mady ,  Lei Miao

IPC: A61K31/167 ,  C07D333/34 ,  A61K45/06 ,  C07C323/63 ,  C07C311/21 ,  C07D295/26 ,  A61K31/495 ,  A61K31/18 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4409 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/451 ,  A61K31/496 ,  A61K31/5355 ,  C07C311/29 ,  C07C229/64 ,  C07C233/81 ,  C07C235/56

CPC classification number: C07D333/34 ,  A61K31/167 ,  A61K31/18 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4409 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/451 ,  A61K31/495 ,  A61K31/496 ,  A61K31/5355 ,  A61K45/06 ,  C07C229/64 ,  C07C233/81 ,  C07C235/56 ,  C07C311/21 ,  C07C311/29 ,  C07C323/63 ,  C07D295/26 ,  A61K2300/00

Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having benzoic acid structure which function as inhibitors of Mcl-1 protein, and their use as therapeutics for the treatment of cancer and other diseases.

公开(公告)号：US09394303B2

公开(公告)日：2016-07-19

申请号：US14678267

申请日：2015-04-03

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Zaneta Nikolovska-Coleska ,  Fardokht Abulwerdi ,  Hollis Showalter ,  Lei Miao ,  Jeanne Stuckey ,  Ahmed Mady

IPC: C07D401/14 ,  A61K31/437 ,  C07D471/04 ,  A61K31/5377 ,  A61K45/06 ,  A61N5/10

CPC classification number: C07D471/04 ,  A61K31/4162 ,  A61K31/437 ,  A61K31/5377 ,  A61K45/06 ,  A61N5/10 ,  A61N2005/1098

Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having pyrazolopyridine structure which function as inhibitors of Mcl-1 protein, and their use as therapeutics for the treatment of cancer and other diseases.

Abstract translation: 本发明在医药化学领域。 特别地，本发明涉及一类新颖的具有吡唑并吡啶结构的小分子，其作为Mcl-1蛋白的抑制剂，其用作治疗癌症和其它疾病的治疗剂。

公开(公告)号：US20150284387A1

公开(公告)日：2015-10-08

申请号：US14678267

申请日：2015-04-03

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Zaneta Nikolovska-Coleska ,  Fardokht Abulwerdi ,  Hollis Showalter ,  Lei Miao ,  Jeanne Stuckey ,  Ahmed Mady

IPC: C07D471/04 ,  A61N5/10 ,  A61K31/5377 ,  A61K31/437 ,  A61K45/06

CPC classification number: C07D471/04 ,  A61K31/4162 ,  A61K31/437 ,  A61K31/5377 ,  A61K45/06 ,  A61N5/10 ,  A61N2005/1098

Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having pyrazolopyridine structure which function as inhibitors of Mcl-1 protein, and their use as therapeutics for the treatment of cancer and other diseases.

Abstract translation: 本发明在医药化学领域。 特别地，本发明涉及一类新颖的具有吡唑并吡啶结构的小分子，其作为Mcl-1蛋白的抑制剂，其用作治疗癌症和其它疾病的治疗剂。

公开(公告)号：US20160304485A1

公开(公告)日：2016-10-20

申请号：US15134098

申请日：2016-04-20

Applicant: The Regents of the University of Michigan

Inventor： Zaneta Nikolovska-Coleska ,  Jeanne A. Stuckey ,  Ahmed Mady ,  Lei Miao

IPC: C07D333/34 ,  C07C323/63 ,  A61K31/495 ,  C07C311/21 ,  A61K31/381 ,  C07D295/26 ,  A61K45/06 ,  A61K31/196

CPC classification number: C07D333/34 ,  A61K31/167 ,  A61K31/18 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4409 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/451 ,  A61K31/495 ,  A61K31/496 ,  A61K31/5355 ,  A61K45/06 ,  C07C229/64 ,  C07C233/81 ,  C07C235/56 ,  C07C311/21 ,  C07C311/29 ,  C07C323/63 ,  C07D295/26 ,  A61K2300/00

Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having benzoic acid structure which function as inhibitors of Mcl-1 protein, and their use as therapeutics for the treatment of cancer and other diseases.

Abstract translation: 本发明在医药化学领域。 特别地，本发明涉及一类具有苯甲酸结构的小分子，其作为Mcl-1蛋白的抑制剂，以及它们作为治疗癌症和其它疾病的治疗剂的用途。