公开(公告)号：US09394303B2

公开(公告)日：2016-07-19

申请号：US14678267

申请日：2015-04-03

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Zaneta Nikolovska-Coleska ,  Fardokht Abulwerdi ,  Hollis Showalter ,  Lei Miao ,  Jeanne Stuckey ,  Ahmed Mady

IPC: C07D401/14 ,  A61K31/437 ,  C07D471/04 ,  A61K31/5377 ,  A61K45/06 ,  A61N5/10

CPC classification number: C07D471/04 ,  A61K31/4162 ,  A61K31/437 ,  A61K31/5377 ,  A61K45/06 ,  A61N5/10 ,  A61N2005/1098

Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having pyrazolopyridine structure which function as inhibitors of Mcl-1 protein, and their use as therapeutics for the treatment of cancer and other diseases.

Abstract translation: 本发明在医药化学领域。 特别地，本发明涉及一类新颖的具有吡唑并吡啶结构的小分子，其作为Mcl-1蛋白的抑制剂，其用作治疗癌症和其它疾病的治疗剂。

公开(公告)号：US11148998B2

公开(公告)日：2021-10-19

申请号：US15987274

申请日：2018-05-23

Applicant: The Regents of the University of Michigan

Inventor： James Varani ,  Hollis Showalter ,  Andy White ,  Kent J. Johnson

IPC: A61K45/06 ,  C07C235/30 ,  C07D209/54 ,  C07D305/06 ,  C07C233/50 ,  C07C233/31 ,  C07D211/74 ,  C07D207/24 ,  A61P17/10 ,  A61P17/06 ,  A61P35/02 ,  A61P17/02

Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a dimethyl-nonatetraenyl-trimethyl-cyclohexyl structure useful as therapeutics for the treatment of subjects suffering from disorders characterized by abnormal proliferation and/or abnormal differentiation of cells, in particular of cells of which the growth and differentiation is sensitive to the actions of retinoids.

公开(公告)号：US20180339961A1

公开(公告)日：2018-11-29

申请号：US15987274

申请日：2018-05-23

Applicant: The Regents of the University of Michigan

Inventor： James Varani ,  Hollis Showalter ,  Andy White ,  Kent J. Johnson

IPC: C07C235/30 ,  A61P17/02 ,  A61P17/10 ,  A61P17/06 ,  A61P35/02

Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a dimethyl-nonatetraenyl-trimethyl-cyclohexyl structure useful as therapeutics for the treatment of subjects suffering from disorders characterized by abnormal proliferation and/or abnormal differentiation of cells, in particular of cells of which the growth and differentiation is sensitive to the actions of retinoids.

公开(公告)号：US20150284387A1

公开(公告)日：2015-10-08

申请号：US14678267

申请日：2015-04-03

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Zaneta Nikolovska-Coleska ,  Fardokht Abulwerdi ,  Hollis Showalter ,  Lei Miao ,  Jeanne Stuckey ,  Ahmed Mady

IPC: C07D471/04 ,  A61N5/10 ,  A61K31/5377 ,  A61K31/437 ,  A61K45/06

CPC classification number: C07D471/04 ,  A61K31/4162 ,  A61K31/437 ,  A61K31/5377 ,  A61K45/06 ,  A61N5/10 ,  A61N2005/1098

Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having pyrazolopyridine structure which function as inhibitors of Mcl-1 protein, and their use as therapeutics for the treatment of cancer and other diseases.

Abstract translation: 本发明在医药化学领域。 特别地，本发明涉及一类新颖的具有吡唑并吡啶结构的小分子，其作为Mcl-1蛋白的抑制剂，其用作治疗癌症和其它疾病的治疗剂。