公开(公告)号：US20180186779A1

公开(公告)日：2018-07-05

申请号：US15738606

申请日：2016-06-27

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Scott D. Larsen ,  John J.G. Tesmer ,  Helen Waldschmidt ,  Kristoff Homan ,  Michael William Wilson

IPC: C07D405/14 ,  C07D405/12 ,  C07D401/12 ,  C07D401/14 ,  A61P9/00 ,  A61P9/12

CPC classification number: C07D405/14 ,  A61P9/00 ,  A61P9/12 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12

Abstract: Disclosed herein are novel GRK inhibitors and methods for their use in treating or preventing heart disease, such as cardiac failure, cardiac hypertrophy, and hypertension. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salt thereof, wherein the substituents are as described.

公开(公告)号：US10329283B2

公开(公告)日：2019-06-25

申请号：US15738606

申请日：2016-06-27

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Scott D. Larsen ,  John J. G. Tesmer ,  Helen Waldschmidt ,  Kristoff Homan ,  Michael William Wilson

IPC: C07D405/14 ,  C07D401/14 ,  C07D401/12 ,  C07D405/12 ,  A61P9/00 ,  A61P9/12

Abstract: Disclosed herein are novel GRK inhibitors and methods for their use in treating or preventing heart disease, such as cardiac failure, cardiac hypertrophy, and hypertension. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salt thereof, wherein the substituents are as described.

公开(公告)号：US10023564B2

公开(公告)日：2018-07-17

申请号：US15501888

申请日：2015-08-10

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Scott D. Larsen ,  Kristoff Homan ,  Helen Waldschmidt ,  John J. G. Tesmer

IPC: C07D413/14 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14

Abstract: Disclosed herein are novel GRK2 inhibitors and methods for their use in treating or preventing heart disease, such as cardiac failure, cardiac hypertrophy, and hypertension. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salt thereof: wherein the substituents are as described.

公开(公告)号：US20170240538A1

公开(公告)日：2017-08-24

申请号：US15501888

申请日：2015-08-10

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Scott D. Larsen ,  Kristoff Homan ,  Helen Waldschmidt ,  John J.G. Tesmer

IPC: C07D413/14 ,  C07D405/14 ,  C07D403/14 ,  C07D401/14 ,  C07D403/12

CPC classification number: C07D413/14 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14

Abstract: Disclosed herein are novel GRK2 inhibitors and methods for their use in treating or preventing heart disease, such as cardiac failure, cardiac hypertrophy, and hypertension. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salt thereof: wherein the substituents are as described.