公开(公告)号：US10768150B2

公开(公告)日：2020-09-08

申请号：US15724665

申请日：2017-10-04

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Xudong Fan ,  Jiwon Lee ,  Menglian Zhou ,  Hongbo Zhu ,  Katsuo Kurabayashi

IPC: G01N30/46 ,  G01N30/02

Abstract: The present disclosure provides a method for conducting comprehensive chromatography analysis. Broadly, the method comprises separating a sample in a first chromatographic column to generate a primary stream, which is directed toward a non-modulator switching system comprising at least one micro-switch and at least one valve. The non-modulator switching system is continuously operated to: (a) selectively direct a portion of the primary stream to one of a plurality of thermal injectors and accumulating the portion of the primary stream for a predetermined amount of time; (b) inject the portion of the primary stream into one of a plurality of secondary chromatographic columns; (c) detect one or more analytes in a secondary stream exiting the secondary chromatographic column; and repeat (a)-(c) to selectively direct other portions of the primary stream to other thermal injectors and secondary chromatographic columns until all of the analytes in the sample are detected.

公开(公告)号：US10718738B2

公开(公告)日：2020-07-21

申请号：US15685139

申请日：2017-08-24

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Xudong Fan ,  Hongbo Zhu ,  Katsuo Kurabayashi

IPC: G01N27/64 ,  G01N27/66

Abstract: A discharge ionization current detector for ionizing and detecting a sample component where the sample component is ionized by UV light is provided. The detector includes a UV light source, and a microfluidic channel having a first surface including a conducting or semiconducting material and an opposing second surface including a conducting or semiconducting material, one of the first surface and the second surface being a collection electrode and the other of the first surface and the second surface being a bias electrode, the microfluidic channel being configured to receive a sample component. The microfluidic channel is in fluid communication with the UV light source such that, when activated, UV light from the UV light source can enter the microfluidic channel and ionize the sample component, which releases an electron, and the ionized sample component and electron are detected by the collection and bias electrodes.

公开(公告)号：US10705061B2

公开(公告)日：2020-07-07

申请号：US15571792

申请日：2016-05-04

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Xudong Fan ,  Hongbo Zhu ,  Robert Nidetz ,  Katsuo Kurabayashi ,  Menglian Zhou ,  Jiwon Lee

IPC: G01N30/64 ,  G01N30/74 ,  G01N27/66 ,  G01N27/68 ,  G01N30/60

Abstract: A rapid flow-through, highly sensitive microfluidic photoionization detector (PID) which is micro-fabricated directly onto a substrate, such as a conductive silicon wafer, is provided. The microfluidic PID has an ionization chamber volume of less than 9 μL. The microfluidic PID may have a flow through design with a microfluidic channel defines a serpentine pattern on the substrate. The flow through design of the microfluidic PID results in negligible dead volume, thus allowing a shortened response time over existing commercially available designs. Such microfluidic PIDs are particularly useful with gas chromatography (GC), including microGC and multi-dimensional microGC systems. Methods for calibrating PIDs are also provided.

公开(公告)号：US12038408B2

公开(公告)日：2024-07-16

申请号：US17282671

申请日：2019-10-02

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Xudong Fan ,  Hongbo Zhu ,  Katsuo Kurabayashi

IPC: B01D53/22 ,  G01N27/64 ,  G01N30/46 ,  G01N30/64

CPC classification number: G01N27/64 ,  G01N30/463 ,  G01N30/64

Abstract: An integrated microfluidic photoionization detector (PID) is provided including a microfluidic ionization chamber a microfluidic ultraviolet radiation chamber that is configured to generate ultraviolet photons. An ultrathin transmissive window is disposed between the microfluidic ionization chamber and the microfluidic ultraviolet radiation chamber that permits the ultraviolet photons to pass from the microfluidic ultraviolet radiation chamber into the microfluidic ionization chamber. Detection systems for one or more VOC analytes are also provided that include a gas chromatography (GC) unit including at least one gas chromatography column and an integrated microfluidic photoionization detector (PID) disposed downstream of the gas chromatography (GC) unit.

公开(公告)号：US20180095060A1

公开(公告)日：2018-04-05

申请号：US15724665

申请日：2017-10-04

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Xudong Fan ,  Jiwon Lee ,  Menglian Zhou ,  Hongbo Zhu ,  Katsuo Kurabayashi

IPC: G01N30/46

Abstract: The present disclosure provides a method for conducting comprehensive chromatography analysis. Broadly, the method comprises separating a sample in a first chromatographic column to generate a primary stream, which is directed toward a non-modulator switching system comprising at least one micro-switch and at least one valve. The non-modulator switching system is continuously operated to: (a) selectively direct a portion of the primary stream to one of a plurality of thermal injectors and accumulating the portion of the primary stream for a predetermined amount of time; (b) inject the portion of the primary stream into one of a plurality of secondary chromatographic columns; (c) detect one or more analytes in a secondary stream exiting the secondary chromatographic column; and repeat (a)-(c) to selectively direct other portions of the primary stream to other thermal injectors and secondary chromatographic columns until all of the analytes in the sample are detected.