公开(公告)号：US10705061B2

公开(公告)日：2020-07-07

申请号：US15571792

申请日：2016-05-04

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Xudong Fan ,  Hongbo Zhu ,  Robert Nidetz ,  Katsuo Kurabayashi ,  Menglian Zhou ,  Jiwon Lee

IPC: G01N30/64 ,  G01N30/74 ,  G01N27/66 ,  G01N27/68 ,  G01N30/60

Abstract: A rapid flow-through, highly sensitive microfluidic photoionization detector (PID) which is micro-fabricated directly onto a substrate, such as a conductive silicon wafer, is provided. The microfluidic PID has an ionization chamber volume of less than 9 μL. The microfluidic PID may have a flow through design with a microfluidic channel defines a serpentine pattern on the substrate. The flow through design of the microfluidic PID results in negligible dead volume, thus allowing a shortened response time over existing commercially available designs. Such microfluidic PIDs are particularly useful with gas chromatography (GC), including microGC and multi-dimensional microGC systems. Methods for calibrating PIDs are also provided.

公开(公告)号：US20180095060A1

公开(公告)日：2018-04-05

申请号：US15724665

申请日：2017-10-04

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Xudong Fan ,  Jiwon Lee ,  Menglian Zhou ,  Hongbo Zhu ,  Katsuo Kurabayashi

IPC: G01N30/46

Abstract: The present disclosure provides a method for conducting comprehensive chromatography analysis. Broadly, the method comprises separating a sample in a first chromatographic column to generate a primary stream, which is directed toward a non-modulator switching system comprising at least one micro-switch and at least one valve. The non-modulator switching system is continuously operated to: (a) selectively direct a portion of the primary stream to one of a plurality of thermal injectors and accumulating the portion of the primary stream for a predetermined amount of time; (b) inject the portion of the primary stream into one of a plurality of secondary chromatographic columns; (c) detect one or more analytes in a secondary stream exiting the secondary chromatographic column; and repeat (a)-(c) to selectively direct other portions of the primary stream to other thermal injectors and secondary chromatographic columns until all of the analytes in the sample are detected.

公开(公告)号：US10768150B2

公开(公告)日：2020-09-08

申请号：US15724665

申请日：2017-10-04

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Xudong Fan ,  Jiwon Lee ,  Menglian Zhou ,  Hongbo Zhu ,  Katsuo Kurabayashi

IPC: G01N30/46 ,  G01N30/02

Abstract: The present disclosure provides a method for conducting comprehensive chromatography analysis. Broadly, the method comprises separating a sample in a first chromatographic column to generate a primary stream, which is directed toward a non-modulator switching system comprising at least one micro-switch and at least one valve. The non-modulator switching system is continuously operated to: (a) selectively direct a portion of the primary stream to one of a plurality of thermal injectors and accumulating the portion of the primary stream for a predetermined amount of time; (b) inject the portion of the primary stream into one of a plurality of secondary chromatographic columns; (c) detect one or more analytes in a secondary stream exiting the secondary chromatographic column; and repeat (a)-(c) to selectively direct other portions of the primary stream to other thermal injectors and secondary chromatographic columns until all of the analytes in the sample are detected.