公开(公告)号：US11998513B2

公开(公告)日：2024-06-04

申请号：US16976382

申请日：2019-02-28

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Joshua C. Doverspike ,  James Phan ,  Jianfeng Wu ,  Chuanwu Xi ,  Yu Qin ,  Mark E. Meyerhoff ,  Yang Zhou

IPC: A61K31/04 ,  A61K31/198 ,  A61K33/30 ,  A61K38/06 ,  A61K47/06 ,  B01J23/72 ,  B01J31/02 ,  A61K9/00 ,  A61K9/06

CPC classification number: A61K31/04 ,  A61K31/198 ,  A61K33/30 ,  A61K38/063 ,  A61K47/06 ,  B01J23/72 ,  B01J31/0272 ,  A61K9/0014 ,  A61K9/06

Abstract: A two-part topical composition includes a first composition including a S-nitrosothiol nitric oxide donor and a carrier, and a second composition including zinc oxide. The second composition is to be mixed with the first composition. The zinc oxide reacts with the S-nitrosothiol nitric oxide donor at a temperature ranging from about 20° C. to about 40° C. to enhance a rate of release of nitric oxide from a mixture of the first composition and the second composition.