公开(公告)号：US12000782B2

公开(公告)日：2024-06-04

申请号：US17421809

申请日：2020-01-09

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Xudong Fan ,  Xueding Wang ,  Xuzhou Li ,  Yu Qin ,  Xiaotian Tan ,  Yu-Cheng Chen ,  Qiushu Chen

IPC: G01N21/63 ,  A61B5/00 ,  H01S3/08 ,  H01S3/083 ,  H01S3/094

CPC classification number: G01N21/63 ,  A61B5/6876 ,  H01S3/08059 ,  H01S3/083 ,  H01S3/094076 ,  G01N2201/06113

Abstract: A laser whose emission is modulated by ultrasound is presented. The laser is usually micron-sized. In response to ultrasound modulation, the laser emission increases and decreases. Such a change in emission can be detected by external optical detectors. This type of laser can be used as a new type of imaging modality, in which laser emission in combination with sound waves or ultrasound waves, is used for imaging Laser emission has a much narrower spectral linewidth and stronger intensity than fluorescence and therefore is able to achieve higher sensitivity, whereas sound waves are used to provide a better spatial resolution of the laser emission from the laser. In ultrasound modulated laser based imaging, multiple lasers can be placed inside cells or tissues.

公开(公告)号：US11571538B2

公开(公告)日：2023-02-07

申请号：US16603169

申请日：2018-04-11

Applicant: The Regents of the University of Michigan

Inventor： Mark E. Meyerhoff ,  Nicolai Lehnert ,  Yu Qin ,  Andrew Hunt ,  Elizabeth J. Brisbois ,  Hang Ren

IPC: A61M16/12 ,  A61M16/08 ,  A61M16/10 ,  A61M1/16 ,  A61M1/34 ,  A61M25/00 ,  A61K33/00 ,  A61M35/00

Abstract: A gas delivery device includes a nitric oxide generating system. The system has a medium including a source of nitrite ions. A working electrode is in contact with the medium. A Cu(II)-ligand complex is in contact with the working electrode. A reference/counter electrode is, or a reference electrode and a counter electrode are in contact with the medium and separated from the working electrode. An inlet conduit is to deliver nitrogen gas to the medium, and an outlet conduit is to transport a stream of nitrogen gas and nitric oxide from the medium. An inspiratory gas conduit is operatively connected to the outlet conduit to introduce an oxygen-containing gas and form an output gas stream of the gas delivery device.

公开(公告)号：US20170216550A1

公开(公告)日：2017-08-03

申请号：US15484981

申请日：2017-04-11

Applicant: The Regents of the University of Michigan

Inventor： Mark E. Meyerhoff ,  Robert H. Bartlett ,  Nicolai Lehnert ,  Yu Qin ,  Andrew P. Hunt ,  Elizabeth J. Brisbois ,  Hang Ren

IPC: A61M16/12 ,  A61M1/34 ,  A61M16/10 ,  A61M1/16 ,  A61M16/08

CPC classification number: A61M16/12 ,  A61M1/1698 ,  A61M1/342 ,  A61M1/3462 ,  A61M16/0875 ,  A61M25/0043 ,  A61M35/00 ,  A61M2016/1025 ,  A61M2016/1035 ,  A61M2025/0057 ,  A61M2202/0208 ,  A61M2202/0275 ,  A61M2202/0007

Abstract: A gas delivery device includes a nitric oxide generating system. The system has a medium including a source of nitrite ions. A working electrode is in contact with the medium. A Cu(II)-ligand complex is in contact with the working electrode. A reference/counter electrode is, or a reference electrode and a counter electrode are in contact with the medium and separated from the working electrode. An inlet conduit is to deliver nitrogen gas to the medium, and an outlet conduit is to transport a stream of nitrogen gas and nitric oxide from the medium. An inspiratory gas conduit is operatively connected to the outlet conduit to introduce an oxygen-containing gas and form an output gas stream of the gas delivery device.

公开(公告)号：US11998513B2

公开(公告)日：2024-06-04

申请号：US16976382

申请日：2019-02-28

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Joshua C. Doverspike ,  James Phan ,  Jianfeng Wu ,  Chuanwu Xi ,  Yu Qin ,  Mark E. Meyerhoff ,  Yang Zhou

IPC: A61K31/04 ,  A61K31/198 ,  A61K33/30 ,  A61K38/06 ,  A61K47/06 ,  B01J23/72 ,  B01J31/02 ,  A61K9/00 ,  A61K9/06

CPC classification number: A61K31/04 ,  A61K31/198 ,  A61K33/30 ,  A61K38/063 ,  A61K47/06 ,  B01J23/72 ,  B01J31/0272 ,  A61K9/0014 ,  A61K9/06

Abstract: A two-part topical composition includes a first composition including a S-nitrosothiol nitric oxide donor and a carrier, and a second composition including zinc oxide. The second composition is to be mixed with the first composition. The zinc oxide reacts with the S-nitrosothiol nitric oxide donor at a temperature ranging from about 20° C. to about 40° C. to enhance a rate of release of nitric oxide from a mixture of the first composition and the second composition.

公开(公告)号：US10449321B2

公开(公告)日：2019-10-22

申请号：US15484981

申请日：2017-04-11

Applicant: The Regents of the University of Michigan

Inventor： Mark E. Meyerhoff ,  Nicolai Lehnert ,  Yu Qin ,  Andrew P. Hunt ,  Elizabeth J. Brisbois ,  Hang Ren

IPC: A61M16/12 ,  A61M1/16 ,  A61M1/34 ,  A61M16/08 ,  A61M16/10 ,  A61M25/00 ,  A61M35/00 ,  A61K33/00

Abstract: A gas delivery device includes a nitric oxide generating system. The system has a medium including a source of nitrite ions. A working electrode is in contact with the medium. A Cu(II)-ligand complex is in contact with the working electrode. A reference/counter electrode is, or a reference electrode and a counter electrode are in contact with the medium and separated from the working electrode. An inlet conduit is to deliver nitrogen gas to the medium, and an outlet conduit is to transport a stream of nitrogen gas and nitric oxide from the medium. An inspiratory gas conduit is operatively connected to the outlet conduit to introduce an oxygen-containing gas and form an output gas stream of the gas delivery device.