公开(公告)号：US20150273025A1

公开(公告)日：2015-10-01

申请号：US14431171

申请日：2013-09-27

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Chuanwu Xi ,  Benjamin Levi ,  Jianfeng Wu ,  Stewart C. Wang

IPC: A61K38/46 ,  A61K31/795 ,  A61K45/06 ,  A61K38/12

CPC classification number: A61K38/46 ,  A61K31/795 ,  A61K38/08 ,  A61K38/12 ,  A61K45/06 ,  C12Y306/01005 ,  A61K2300/00

Abstract: Provided herein is technology relating to compositions comprising apyrase and particularly, but not exclusively, to compositions comprising apyrase, methods of treating with apyrase, and uses of apyrase related to treating a subject, e.g., a subject suffering from a microbial infection, a subject who has a wound or burn and is in need of an antimicrobial treatment, and/or a subject in need of treatment for heterotopic ossification.

Abstract translation: 本文提供的技术涉及包含腺苷二磷酸酶的组合物，特别地但不排他地涉及包含腺苷二磷酸酶的组合物，用脱酰酶处理的方法，以及与治疗受试者（例如，患有微生物感染的受试者）有关的腺苷三磷酸酶的用途，受试者 具有伤口或烧伤并且需要抗微生物治疗，和/或需要治疗异位骨化的受试者。

公开(公告)号：US11998513B2

公开(公告)日：2024-06-04

申请号：US16976382

申请日：2019-02-28

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Joshua C. Doverspike ,  James Phan ,  Jianfeng Wu ,  Chuanwu Xi ,  Yu Qin ,  Mark E. Meyerhoff ,  Yang Zhou

IPC: A61K31/04 ,  A61K31/198 ,  A61K33/30 ,  A61K38/06 ,  A61K47/06 ,  B01J23/72 ,  B01J31/02 ,  A61K9/00 ,  A61K9/06

CPC classification number: A61K31/04 ,  A61K31/198 ,  A61K33/30 ,  A61K38/063 ,  A61K47/06 ,  B01J23/72 ,  B01J31/0272 ,  A61K9/0014 ,  A61K9/06

Abstract: A two-part topical composition includes a first composition including a S-nitrosothiol nitric oxide donor and a carrier, and a second composition including zinc oxide. The second composition is to be mixed with the first composition. The zinc oxide reacts with the S-nitrosothiol nitric oxide donor at a temperature ranging from about 20° C. to about 40° C. to enhance a rate of release of nitric oxide from a mixture of the first composition and the second composition.

公开(公告)号：US10239918B2

公开(公告)日：2019-03-26

申请号：US15576494

申请日：2016-05-26

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： David H. Sherman ,  Fengan Yu ,  Chuanwu Xi ,  Jianfeng Wu ,  Pamela J. Schultz ,  Ashootosh Tripathi ,  Sung Ryeol Park

IPC: C07K4/00 ,  C07K7/06 ,  A01N37/46 ,  A01N43/76 ,  C07K5/00 ,  C07K5/083 ,  C07K5/103 ,  C07D413/12 ,  A61K38/07 ,  A61K45/06 ,  C07K14/195 ,  C12N9/88

Abstract: Provided herein are biofilm inhibitors obtained from marine microbial derived natural product extracts from Streptomyces gandocaensis, resulting in biofilm inhibitors, cahuitamycins. Also provided are mutant S. gandocaensis, methods of inhibiting biofilm formation, methods of producing, or increasing the production of, cahuitamycins, methods for synthesizing cahuitamycins, and methods of purifying cahuitamycins.

公开(公告)号：US20140205586A1

公开(公告)日：2014-07-24

申请号：US14248080

申请日：2014-04-08

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Chuanwu Xi ,  Jianfeng Wu

IPC: A01N63/02

CPC classification number: A01N63/02 ,  A01N57/16 ,  A61K38/46 ,  C12Y306/01005

Abstract: The invention relates to control of biofilm development. Specifically, some embodiments of the present invention relate to control of bacterial biofilm formation through addition or breakdown of signal(s) that induce biofilm formation. More specifically, some embodiments of the present invention relate to control (e.g., promotion, prevention) of biofilm development by application or hydrolysis of adenosine triphospate (ATP), deoxyadenosine triphosphate (dATP), or derivatives or analogs thereof (e.g., through application or administration of an agent that hydrolyzes ATP, dATP, or derivatives or analogs thereof (e.g., apyrase)).

Abstract translation: 本发明涉及生物膜发育的控制。 具体来说，本发明的一些实施方案涉及通过加入或分解诱导生物膜形成的信号来控制细菌生物膜形成。 更具体地，本发明的一些实施方案涉及通过应用或水解腺苷三磷酸（ATP），脱氧腺苷三磷酸（dATP）或其衍生物或类似物（例如通过应用或 施用水解ATP，dATP或其衍生物或类似物（例如apyrase）的试剂）。

公开(公告)号：US20180162906A1

公开(公告)日：2018-06-14

申请号：US15576494

申请日：2016-05-26

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： David H. Sherman ,  Fengan Yu ,  Chuanwu Xi ,  Jianfeng Wu ,  Pamela Schultz ,  Ashootosh Tripathi ,  Sung Ryeol Park

IPC: C07K7/06 ,  C07K5/103 ,  A61K38/07 ,  A01N43/76 ,  A01N37/46 ,  A61K45/06 ,  C12N9/88 ,  C07K14/195

CPC classification number: C07K7/06 ,  A01N37/46 ,  A01N43/76 ,  A61K38/07 ,  A61K45/06 ,  C07D413/12 ,  C07K5/00 ,  C07K5/081 ,  C07K5/1013 ,  C07K14/195 ,  C12N9/88 ,  C12Y402/99021 ,  Y02A50/473

Abstract: Provided herein are biofilm inhibitors obtained from marine microbial derived natural product extracts from Streptomyces gandocaensis, resulting in biofilm inhibitors, cahuitamycins. Also provided are mutant S. gandocaensis, methods of inhibiting biofilm formation, methods of producing, or increasing the production of, cahuitamycins, methods for synthesizing cahuitamycins, and methods of purifying cahuitamycins.