公开(公告)号：US10859585B2

公开(公告)日：2020-12-08

申请号：US16235096

申请日：2018-12-28

Applicant: THE SCRIPPS RESEARCH INSTITUTE

Inventor： Benjamin F. Cravatt ,  Micah J. Niphakis ,  Kenneth Lum ,  Bruno Correia ,  Armand Cognetta ,  Jonathan Hulce

IPC: G01N33/92 ,  G01N33/68

Abstract: Disclosed herein are methods, compositions, probes, assays and kits for identifying a lipid binding protein as a drug binding target. Also disclosed herein are methods, compositions, and probes for mapping a ligand binding site on a lipid binding protein, identification of lipid binding proteins, generating drug-lipid binding protein profiles, high throughput drug screening, and identification of drugs as potential lipid binding protein ligands.

公开(公告)号：US11535597B2

公开(公告)日：2022-12-27

申请号：US16478444

申请日：2018-01-17

Applicant: The Scripps Research Institute

Inventor： Benjamin F. Cravatt ,  Christopher G. Parker ,  Bruno Correia

IPC: C07D229/02 ,  C07D223/06 ,  C07C233/06 ,  C07D295/10 ,  C07D317/46 ,  C07D401/10 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  G01N1/28 ,  G01N1/44 ,  G01N33/68

Abstract: Disclosed herein are methods for identifying proteins as targets for interaction with a small molecule ligand. Also disclosed herein are small molecule ligands and compositions for use in profiling druggable proteins.

公开(公告)号：US20190293666A1

公开(公告)日：2019-09-26

申请号：US16235096

申请日：2018-12-28

Applicant: THE SCRIPPS RESEARCH INSTITUTE

Inventor： Benjamin F. Cravatt ,  Micah J. Niphakis ,  Kenneth Lum ,  Bruno Correia ,  Armand Cognetta ,  Jonathan Hulce

IPC: G01N33/92 ,  G01N33/68

Abstract: Disclosed herein are methods, compositions, probes, assays and kits for identifying a lipid binding protein as a drug binding target. Also disclosed herein are methods, compositions, and probes for mapping a ligand binding site on a lipid binding protein, identification of lipid binding proteins, generating drug-lipid binding protein profiles, high throughput drug screening, and identification of drugs as potential lipid binding protein ligands.

公开(公告)号：US10168342B2

公开(公告)日：2019-01-01

申请号：US15080767

申请日：2016-03-25

Applicant: THE SCRIPPS RESEARCH INSTITUTE

Inventor： Benjamin F. Cravatt ,  Micah J. Niphakis ,  Kenneth Lum ,  Bruno Correia ,  Armand Cognetta ,  Jonathan Hulce

IPC: G01N33/92 ,  G01N33/68

Abstract: Disclosed herein are methods, compositions, probes, assays and kits for identifying a lipid binding protein as a drug binding target. Also disclosed herein are methods, compositions, and probes for mapping a ligand binding site on a lipid binding protein, identification of lipid binding proteins, generating drug-lipid binding protein profiles, high throughput drug screening, and identification of drugs as potential lipid binding protein ligands.