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公开(公告)号：US10859585B2
公开(公告)日：2020-12-08
申请号：US16235096
申请日：2018-12-28
Applicant: THE SCRIPPS RESEARCH INSTITUTE
Inventor： Benjamin F. Cravatt , Micah J. Niphakis , Kenneth Lum , Bruno Correia , Armand Cognetta , Jonathan Hulce
Abstract: Disclosed herein are methods, compositions, probes, assays and kits for identifying a lipid binding protein as a drug binding target. Also disclosed herein are methods, compositions, and probes for mapping a ligand binding site on a lipid binding protein, identification of lipid binding proteins, generating drug-lipid binding protein profiles, high throughput drug screening, and identification of drugs as potential lipid binding protein ligands.
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公开(公告)号：US09567302B2
公开(公告)日：2017-02-14
申请号：US14383076
申请日：2013-03-15
Applicant: Abide Therapeutics, Inc. , The Scripps Research Institute
Inventor： Justin S. Cisar , Cheryl A. Grice , Todd K. Jones , Dong-Hui Wang , Olivia Weber , Benjamin F. Cravatt , Micah J. Niphakis , Armand Cognetta , Jae Won Chang
IPC: C07D207/46 , C07D401/12 , C07D405/14 , C07D413/12 , C07D413/14 , A61K31/496 , A61K31/454 , C07D403/12 , C07D401/14 , C07D491/08 , C07D233/80 , C07D403/14 , C07D417/12 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/107 , C07D498/08 , C07D209/48
CPC classification number: C07D207/46 , C07D209/48 , C07D233/80 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/08 , C07D491/107 , C07D498/08
Abstract: Provided herein are carbamate compounds which may be useful in the treatment of for example, pain, solid tumors and/or obesity.
Abstract translation: 本文提供了可用于治疗例如疼痛，实体瘤和/或肥胖症的氨基甲酸酯化合物。
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公开(公告)号：US20190293666A1
公开(公告)日：2019-09-26
申请号：US16235096
申请日：2018-12-28
Applicant: THE SCRIPPS RESEARCH INSTITUTE
Inventor： Benjamin F. Cravatt , Micah J. Niphakis , Kenneth Lum , Bruno Correia , Armand Cognetta , Jonathan Hulce
Abstract: Disclosed herein are methods, compositions, probes, assays and kits for identifying a lipid binding protein as a drug binding target. Also disclosed herein are methods, compositions, and probes for mapping a ligand binding site on a lipid binding protein, identification of lipid binding proteins, generating drug-lipid binding protein profiles, high throughput drug screening, and identification of drugs as potential lipid binding protein ligands.
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公开(公告)号：US10168342B2
公开(公告)日：2019-01-01
申请号：US15080767
申请日：2016-03-25
Applicant: THE SCRIPPS RESEARCH INSTITUTE
Inventor： Benjamin F. Cravatt , Micah J. Niphakis , Kenneth Lum , Bruno Correia , Armand Cognetta , Jonathan Hulce
Abstract: Disclosed herein are methods, compositions, probes, assays and kits for identifying a lipid binding protein as a drug binding target. Also disclosed herein are methods, compositions, and probes for mapping a ligand binding site on a lipid binding protein, identification of lipid binding proteins, generating drug-lipid binding protein profiles, high throughput drug screening, and identification of drugs as potential lipid binding protein ligands.
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