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公开(公告)号：US10859585B2
公开(公告)日：2020-12-08
申请号：US16235096
申请日：2018-12-28
Applicant: THE SCRIPPS RESEARCH INSTITUTE
Inventor： Benjamin F. Cravatt , Micah J. Niphakis , Kenneth Lum , Bruno Correia , Armand Cognetta , Jonathan Hulce
Abstract: Disclosed herein are methods, compositions, probes, assays and kits for identifying a lipid binding protein as a drug binding target. Also disclosed herein are methods, compositions, and probes for mapping a ligand binding site on a lipid binding protein, identification of lipid binding proteins, generating drug-lipid binding protein profiles, high throughput drug screening, and identification of drugs as potential lipid binding protein ligands.
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公开(公告)号：US20150148330A1
公开(公告)日：2015-05-28
申请号：US14599105
申请日：2015-01-16
Applicant: Abide Therapeutics, Inc. , The Scripps Research Institute
Inventor： Justin S. Cisar , Cheryl A. Grice , Todd K. Jones , Micah J. Niphakis , Jae Won Chang , Kenneth M. Lum , Benjamin F. Cravatt
IPC: C07D295/26 , C07D487/04 , C07D471/04 , C07D263/32 , C07D471/10 , C07D317/58 , C07C271/10 , C07D241/04 , C07D207/09 , C07D491/107 , C07D231/56
CPC classification number: C07D295/205 , C07C271/10 , C07C271/12 , C07D205/04 , C07D207/09 , C07D207/14 , C07D213/38 , C07D213/40 , C07D213/55 , C07D215/42 , C07D215/46 , C07D231/12 , C07D231/16 , C07D231/56 , C07D241/04 , C07D261/08 , C07D263/32 , C07D271/06 , C07D295/26 , C07D307/79 , C07D317/46 , C07D317/58 , C07D401/04 , C07D401/10 , C07D403/10 , C07D405/14 , C07D407/06 , C07D413/06 , C07D413/10 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/107
Abstract: This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from indications such as pain, solid tumor cancer and/or obesity comprising administering a disclosed compound or composition.
Abstract translation: 本公开提供了可以是MAGL和/或ABHD6的调节剂的化合物和组合物及其作为药物的用途，其制备方法和包含公开的化合物作为至少一种活性剂的药物组合物。 本公开还提供了治疗有需要的患者的方法，其中患者患有诸如疼痛，实体瘤癌症和/或肥胖的适应症，其包括施用所公开的化合物或组合物。
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公开(公告)号：US09957242B2
公开(公告)日：2018-05-01
申请号：US15272313
申请日：2016-09-21
Applicant: Abide Therapeutics, Inc. , THE SCRIPPS RESEARCH INSTITUTE
Inventor： Justin S. Cisar , Cheryl A. Grice , Todd K. Jones , Micah J. Niphakis , Jae Won Chang , Kenneth M Lum , Benjamin F. Cravatt
IPC: C07D213/55 , C07D231/12 , C07D261/08 , A61K31/496 , C07D295/205 , C07D405/14 , C07D215/42 , C07D213/40 , C07C271/12 , C07D317/46 , C07D317/58 , C07D231/16 , C07D231/56 , C07D241/04 , C07D471/04 , C07D471/10 , C07D487/04 , C07D263/32 , C07D205/04 , C07D491/107 , C07D207/14 , C07D271/06 , C07D295/26 , C07D307/79 , C07D401/04 , C07D407/06 , C07D413/06 , C07C271/10 , C07D207/09 , C07D213/38 , C07D215/46 , C07D401/10 , C07D403/10 , C07D413/10
CPC classification number: C07D295/205 , C07C271/10 , C07C271/12 , C07D205/04 , C07D207/09 , C07D207/14 , C07D213/38 , C07D213/40 , C07D213/55 , C07D215/42 , C07D215/46 , C07D231/12 , C07D231/16 , C07D231/56 , C07D241/04 , C07D261/08 , C07D263/32 , C07D271/06 , C07D295/26 , C07D307/79 , C07D317/46 , C07D317/58 , C07D401/04 , C07D401/10 , C07D403/10 , C07D405/14 , C07D407/06 , C07D413/06 , C07D413/10 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/107
Abstract: This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from indications such as pain, solid tumor cancer and/or obesity comprising administering a disclosed compound or composition.
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公开(公告)号：US20190293666A1
公开(公告)日：2019-09-26
申请号：US16235096
申请日：2018-12-28
Applicant: THE SCRIPPS RESEARCH INSTITUTE
Inventor： Benjamin F. Cravatt , Micah J. Niphakis , Kenneth Lum , Bruno Correia , Armand Cognetta , Jonathan Hulce
Abstract: Disclosed herein are methods, compositions, probes, assays and kits for identifying a lipid binding protein as a drug binding target. Also disclosed herein are methods, compositions, and probes for mapping a ligand binding site on a lipid binding protein, identification of lipid binding proteins, generating drug-lipid binding protein profiles, high throughput drug screening, and identification of drugs as potential lipid binding protein ligands.
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公开(公告)号：US10168342B2
公开(公告)日：2019-01-01
申请号：US15080767
申请日：2016-03-25
Applicant: THE SCRIPPS RESEARCH INSTITUTE
Inventor： Benjamin F. Cravatt , Micah J. Niphakis , Kenneth Lum , Bruno Correia , Armand Cognetta , Jonathan Hulce
Abstract: Disclosed herein are methods, compositions, probes, assays and kits for identifying a lipid binding protein as a drug binding target. Also disclosed herein are methods, compositions, and probes for mapping a ligand binding site on a lipid binding protein, identification of lipid binding proteins, generating drug-lipid binding protein profiles, high throughput drug screening, and identification of drugs as potential lipid binding protein ligands.
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Patent Agency Ranking
公开(公告)号：US09133148B2
公开(公告)日：2015-09-15
申请号：US14599105
申请日：2015-01-16
Applicant: Abide Therapeutics, Inc. , The Scripps Research Institute
Inventor： Justin S. Cisar , Cheryl A. Grice , Todd K. Jones , Micah J. Niphakis , Jae Won Chang , Kenneth M. Lum , Benjamin F. Cravatt
IPC: A61K31/495 , A61K31/496 , C07D207/09 , C07D207/14 , C07D213/56 , C07D205/04 , C07D295/26 , C07D295/205 , C07D487/04 , C07D487/10 , C07D491/107 , C07D405/14 , C07D215/42 , C07D213/40 , C07C271/12 , C07D317/46 , C07D317/58 , C07D231/12 , C07D231/16 , C07D231/56 , C07D241/04 , C07D471/04 , C07D471/10 , C07D261/08 , C07D263/32 , C07D271/06 , C07D307/79 , C07D213/55 , C07D401/04 , C07D407/06 , C07D413/06 , C07C271/10
CPC classification number: C07D295/205 , C07C271/10 , C07C271/12 , C07D205/04 , C07D207/09 , C07D207/14 , C07D213/38 , C07D213/40 , C07D213/55 , C07D215/42 , C07D215/46 , C07D231/12 , C07D231/16 , C07D231/56 , C07D241/04 , C07D261/08 , C07D263/32 , C07D271/06 , C07D295/26 , C07D307/79 , C07D317/46 , C07D317/58 , C07D401/04 , C07D401/10 , C07D403/10 , C07D405/14 , C07D407/06 , C07D413/06 , C07D413/10 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/107
Abstract: This disclosure provides piperazine carbamates and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed piperazine carbamates as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from indications such as pain, solid tumor cancer and/or obesity comprising administering a disclosed compound or composition.
Abstract translation: 本公开提供哌嗪类氨基甲酸酯和可以是MAGL和/或ABHD6的调节剂的组合物及其作为药物的用途，其制备方法和包括公开的哌嗪氨基甲酸酯作为至少一种活性剂的药物组合物。 本公开还提供了治疗有需要的患者的方法，其中患者患有诸如疼痛，实体瘤癌症和/或肥胖的适应症，其包括施用所公开的化合物或组合物。
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公开(公告)号：US20150018335A1
公开(公告)日：2015-01-15
申请号：US14369982
申请日：2013-01-07
Applicant: ABIDE THERAPEUTICS, INC , THE SCRIPPS RESEARCH INSTITUTE
Inventor： Justin S. Cisar , Cheryl A. Grice , Todd K. Jones , Micah J. Niphakis , Jae Won Chang , Kenneth M. Lum , Benjamin F. Cravatt
IPC: C07D295/205 , C07D407/06 , C07D317/58 , C07D205/04 , C07D401/04 , C07D271/06 , C07D295/26 , C07D413/06 , C07D405/14 , C07D213/55
CPC classification number: C07D295/205 , C07C271/10 , C07C271/12 , C07D205/04 , C07D207/09 , C07D207/14 , C07D213/38 , C07D213/40 , C07D213/55 , C07D215/42 , C07D215/46 , C07D231/12 , C07D231/16 , C07D231/56 , C07D241/04 , C07D261/08 , C07D263/32 , C07D271/06 , C07D295/26 , C07D307/79 , C07D317/46 , C07D317/58 , C07D401/04 , C07D401/10 , C07D403/10 , C07D405/14 , C07D407/06 , C07D413/06 , C07D413/10 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/107
Abstract: This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from indications such as pain, solid tumor cancer and/or obesity comprising administering a disclosed compound or composition.
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公开(公告)号：US12018004B2
公开(公告)日：2024-06-25
申请号：US18053582
申请日：2022-11-08
Applicant: H. Lundbeck A/S , THE SCRIPPS RESEARCH INSTITUTE
Inventor： Justin S. Cisar , Cheryl A. Grice , Todd K. Jones , Micah J. Niphakis , Jae Won Chang , Kenneth M. Lum , Benjamin F. Cravatt
IPC: C07D295/205 , A61P25/22 , C07C271/10 , C07C271/12 , C07D205/04 , C07D207/09 , C07D207/14 , C07D213/38 , C07D213/40 , C07D213/55 , C07D215/42 , C07D215/46 , C07D231/12 , C07D231/16 , C07D231/56 , C07D241/04 , C07D261/08 , C07D263/32 , C07D271/06 , C07D295/26 , C07D307/79 , C07D317/46 , C07D317/58 , C07D401/04 , C07D401/10 , C07D403/10 , C07D405/14 , C07D407/06 , C07D413/06 , C07D413/10 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/107
CPC classification number: C07D295/205 , A61P25/22 , C07C271/10 , C07C271/12 , C07D205/04 , C07D207/09 , C07D207/14 , C07D213/38 , C07D213/40 , C07D213/55 , C07D215/42 , C07D215/46 , C07D231/12 , C07D231/16 , C07D231/56 , C07D241/04 , C07D261/08 , C07D263/32 , C07D271/06 , C07D295/26 , C07D307/79 , C07D317/46 , C07D317/58 , C07D401/04 , C07D401/10 , C07D403/10 , C07D405/14 , C07D407/06 , C07D413/06 , C07D413/10 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/107
Abstract: This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from post-traumatic stress disorder comprising administering a disclosed compound or composition.
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公开(公告)号：US11530189B2
公开(公告)日：2022-12-20
申请号：US17195351
申请日：2021-03-08
Applicant: H. Lundbeck A/S , THE SCRIPPS RESEARCH INSTITUTE
Inventor： Justin S. Cisar , Cheryl A. Grice , Todd K. Jones , Micah J. Niphakis , Jae Won Chang , Kenneth M. Lum , Benjamin F. Cravatt
IPC: C07D295/205 , C07C271/12 , C07D317/46 , C07D317/58 , C07D231/12 , C07D231/16 , C07D231/56 , C07D241/04 , C07D471/04 , C07D471/10 , C07D261/08 , C07D487/04 , C07D263/32 , C07D205/04 , C07D491/107 , C07D207/14 , C07D271/06 , C07D307/79 , C07D405/14 , C07D215/42 , C07D213/40 , A61P25/22 , C07D295/26 , C07D213/55 , C07D401/04 , C07D407/06 , C07D413/06 , C07C271/10 , C07D207/09 , C07D213/38 , C07D215/46 , C07D401/10 , C07D403/10 , C07D413/10
Abstract: This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from post-traumatic stress disorder comprising administering a disclosed compound or composition.
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公开(公告)号：US11021453B2
公开(公告)日：2021-06-01
申请号：US16717813
申请日：2019-12-17
Inventor： Justin S. Cisar , Cheryl A. Grice , Todd K. Jones , Micah J. Niphakis , Jae Won Chang , Kenneth M. Lum , Benjamin F. Cravatt
IPC: C07D295/205 , A61P25/22 , C07C271/12 , C07D317/46 , C07D317/58 , C07D231/12 , C07D231/16 , C07D231/56 , C07D241/04 , C07D471/04 , C07D471/10 , C07D261/08 , C07D487/04 , C07D263/32 , C07D205/04 , C07D491/107 , C07D207/14 , C07D271/06 , C07D307/79 , C07D405/14 , C07D215/42 , C07D213/40 , C07D295/26 , C07D213/55 , C07D401/04 , C07D407/06 , C07D413/06 , C07C271/10 , C07D207/09 , C07D213/38 , C07D215/46 , C07D401/10 , C07D403/10 , C07D413/10
Abstract: This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for a method of treating a patient in need thereof, where the patient is suffering from post-traumatic stress disorder comprising administering a disclosed compound or composition.
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