公开(公告)号：US20200061240A1

公开(公告)日：2020-02-27

申请号：US16547175

申请日：2019-08-21

申请人： THE SECANT GROUP, LLC

发明人： Stephanie REED ,  Carissa SMOOT ,  Dennis SHULL ,  Todd CRUMBLING ,  John D'OTTAVIO ,  Peter D. GABRIELE ,  Jeremy J. HARRIS ,  Charles Brendan NICHOLSON ,  Jared ELY

IPC分类号： A61L27/18 ,  A61L27/54 ,  A61K31/522 ,  B33Y80/00 ,  B29C67/24

摘要： A process forms an implantable product including poly(glycerol sebacate) urethane (PGSU) loaded with an active pharmaceutical ingredient (API). The process includes homogeneously mixing a flowable poly(glycerol sebacate) (PGS) resin with the API and a catalyst to form a resin blend. The process also includes homogeneously combining the resin blend with an isocyanate to form a reaction mixture and injecting the reaction mixture to form the PGSU loaded with the API. An implantable product includes a PGSU loaded with an API. In some embodiments, the implantable product includes at least 40% w/w of the API, and the implantable product releases the API by surface degradation of the PGSU at a predetermined release rate for at least three months under physiological conditions. In some embodiments, the PGSU is formed from a PGS reacted with an isocyanate at an isocyanate-to-hydroxyl stoichiometric (crosslinking) ratio in the range of 1:0.25 to 1:1.25.

公开(公告)号：US20210138109A1

公开(公告)日：2021-05-13

申请号：US17148130

申请日：2021-01-13

申请人： THE SECANT GROUP, LLC

发明人： Stephanie REED ,  Carissa SMOOT ,  Dennis SHULL ,  Todd CRUMBLING ,  John D'OTTAVIO ,  Peter D. GABRIELE ,  Jeremy J. HARRIS ,  Charles Brendan NICHOLSON ,  Jared ELY

IPC分类号： A61L27/18 ,  A61L27/54 ,  A61K31/522 ,  B29C67/24 ,  B33Y80/00

摘要： A process forms an implantable product including poly(glycerol sebacate) urethane (PGSU) loaded with an active pharmaceutical ingredient (API). The process includes homogeneously mixing a flowable poly(glycerol sebacate) (PGS) resin with the API and a catalyst to form a resin blend. The process also includes homogeneously combining the resin blend with an isocyanate to form a reaction mixture and injecting the reaction mixture to form the PGSU loaded with the API. An implantable product includes a PGSU loaded with an API. In some embodiments, the implantable product includes at least 40% w/w of the API, and the implantable product releases the API by surface degradation of the PGSU at a predetermined release rate for at least three months under physiological conditions. In some embodiments, the PGSU is formed from a PGS reacted with an isocyanate at an isocyanate-to-hydroxyl stoichiometric (crosslinking) ratio in the range of 1:0.25 to 1:1.25.

公开(公告)号：US20180347307A1

公开(公告)日：2018-12-06

申请号：US15995777

申请日：2018-06-01

申请人： THE SECANT GROUP, LLC ,  CDI ENERGY PRODUCTS, INC.

发明人： Peter D. GABRIELE ,  Dennis SHULL ,  Fred B. PIPPERT

IPC分类号： E21B33/12 ,  E21B33/134 ,  C08L67/00

CPC分类号： E21B33/1208 ,  C08K2201/018 ,  C08L67/00 ,  C09K8/035 ,  E21B33/00 ,  E21B33/134

摘要： Compositions and methods are provided that are beneficial for use in downhole applications, especially oil and gas well bores. A composition includes an elastomer doped with a dopant. The presence of the dopant increases a rate of microbial degradation of the elastomer by a microbe. A method includes forming an article including a doped polymer. The doped polymer includes an elastomer doped with a dopant. The method also includes placing the article in a service environment. The presence of the dopant in the doped polymer increases a rate of microbial degradation of the elastomer by a microbe in the service environment.