公开(公告)号：US20200093902A1

公开(公告)日：2020-03-26

申请号：US16669552

申请日：2019-10-31

申请人： THE TRUSTEES OF DARTMOUTH COLLEGE ,  KING'S COLLEGE LONDON

发明人： Randolph J. NOELLE ,  Sabrina CEERAZ ,  Isabelle LeMERCIER ,  Elizabeth NOWAK ,  Janet LINES ,  Li WANG ,  Mark SPALLER

IPC分类号： A61K39/00 ,  C07K16/28 ,  G01N33/566 ,  C07K7/08 ,  A61K45/06

摘要： The present invention is directed to a peptide, multimer, conjugate, analog, derivative or mimetic thereof that inhibits the activity of VISTA. The invention further contemplates therapeutic use of the VISTA antagonist peptide, multimer, conjugate, derivative or mimetic thereof, including treating or preventing cancer, bacterial infections, viral infections, parasitic infections and fungal infections, as well as research uses of the antagonist.

公开(公告)号：US20210361736A1

公开(公告)日：2021-11-25

申请号：US17186199

申请日：2021-02-26

申请人： KING'S COLLEGE LONDON ,  THE TRUSTEES OF DARTMOUTH COLLEGE

发明人： Randolph J. NOELLE ,  Sabrina CEERAZ ,  Isabelle LEMERCIER ,  Elizabeth NOWAK ,  Janet LINES ,  Li WANG ,  Mark SPALLER

IPC分类号： A61K38/10 ,  C07K7/08 ,  A61K45/06 ,  A61K9/00 ,  A61K39/00 ,  C07K16/28 ,  G01N33/566

摘要： The present invention is directed to a peptide, multimer, conjugate, analog, derivative or mimetic thereof that inhibits the activity of VISTA. The invention further contemplates therapeutic use of the VISTA antagonist peptide, multimer, conjugate, derivative or mimetic thereof, including treating or preventing cancer, bacterial infections, viral infections, parasitic infections and fungal infections, as well as research uses of the antagonist.

公开(公告)号：US20160331803A1

公开(公告)日：2016-11-17

申请号：US15111550

申请日：2015-01-23

申请人： King's College London ,  The Trustees of Dartmouth College

发明人： Randolph J. NOELLE ,  Sabrina CEERAZ ,  Isabelle LEMERCIER ,  Elizabeth NOWAK ,  Janet LINES ,  Li WANG ,  Mark SPALLER

IPC分类号： A61K38/10 ,  G01N33/566 ,  A61K9/00 ,  C07K7/08 ,  A61K45/06

CPC分类号： A61K38/10 ,  A61K9/0019 ,  A61K38/00 ,  A61K45/06 ,  C07K7/08 ,  C07K2319/30 ,  Y02A50/385 ,  Y02A50/387 ,  Y02A50/393 ,  Y02A50/402 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/419 ,  Y02A50/421 ,  Y02A50/423 ,  Y02A50/463 ,  Y02A50/465 ,  Y02A50/467 ,  Y02A50/475 ,  Y02A50/478 ,  Y02A50/491 ,  Y02A50/58

摘要： The present invention is directed to a peptide, multimer, conjugate, analog, derivative or mimetic thereof that inhibits the activity of VISTA. The invention further contemplates therapeutic use of the VISTA antagonist peptide, multimer, conjugate, derivative or mimetic thereof, including treating or preventing cancer, bacterial infections, viral infections, parasitic infections and fungal infections, as well as research uses of the antagonist.

摘要翻译： 本发明涉及抑制VISTA活性的肽，多聚体，缀合物，类似物，衍生物或模拟物。 本发明进一步考虑了VISTA拮抗剂肽，多聚体，缀合物，衍生物或其模拟物的治疗用途，包括治疗或预防癌症，细菌感染，病毒感染，寄生虫感染和真菌感染以及拮抗剂的研究用途。