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公开(公告)号：US09433648B2
公开(公告)日：2016-09-06
申请号：US14757765
申请日：2015-12-23
CPC分类号： A61K35/62 , A01K67/033 , A01N63/00 , A61K9/0014 , A61K31/282 , A61K31/4745 , A61K31/555 , A61K38/21 , A61K45/06 , Y02A50/385 , Y02A50/387 , Y02A50/393 , Y02A50/40 , Y02A50/401 , Y02A50/402 , Y02A50/406 , Y02A50/409 , Y02A50/411 , Y02A50/414 , Y02A50/415 , Y02A50/419 , Y02A50/422 , Y02A50/423 , Y02A50/463 , Y02A50/465 , Y02A50/467 , Y02A50/469 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/479 , Y02A50/481 , Y02A50/483 , Y02A50/491 , A61K2300/00
摘要： Methods are provided for isolating and using a whole-saliva leech extract. The methods can include feeding a phagostimulatory agent to a leech; inducing a regurgitation in the leech, the inducing including placing the leech in an environment having a temperature of less than about 0° C.; and, collecting an unrefined, whole saliva in the regurgitation of the cooled leech. The methods can include revitalizing the leech by warming it at a temperature ranging from about 5° C. to about 40° C. Stable, lyophilized, whole-saliva extracts of a leech are also provided, the extract having a stable activity when stored for use at a temperature below about −20° C., the extract maintaining at least 70% of the activity for at least 6 months. The extracts can be used to treat solid tumors, treat liquid tumors, treat diabetes, treat a viral disease, treat a parasitic disease, treat an antibacterial disease, or serve as an anti-oxidant.
摘要翻译： 提供了分离和使用全唾液水蛭提取物的方法。 所述方法可以包括向水蛭喂养吞噬剂; 诱导水蛭反流，诱导包括将水蛭放置在温度低于约0℃的环境中; 并在冷水蛭的反流中收集未精制的全唾液。 所述方法可以包括通过在约5℃至约40℃的温度范围内升温来振兴水蛭。还提供了稳定的，冻干的全唾液提取物，所述提取物在储存时具有稳定的活性 在低于约-20℃的温度下使用，提取物保持至少6个月的活性的至少70％。 提取物可用于治疗实体瘤，治疗液体肿瘤，治疗糖尿病，治疗病毒性疾病，治疗寄生虫病，治疗抗菌疾病或用作抗氧化剂。
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公开(公告)号：US20160206680A1
公开(公告)日：2016-07-21
申请号：US15071417
申请日：2016-03-16
申请人： Roger Linington , Laura Sanchez
发明人： Roger Linington , Laura Sanchez
IPC分类号： A61K38/08 , A61K31/185 , A61K31/155 , A61K31/555
CPC分类号： A61K38/08 , A61K31/155 , A61K31/185 , A61K31/555 , A61K38/00 , C07K7/06 , Y02A50/401 , Y02A50/409 , Y02A50/411 , Y02A50/414 , Y02A50/415 , Y02A50/419 , Y02A50/422 , Y02A50/423 , Y02A50/491
摘要： A novel structural class of highly N-methylated linear lipopeptide compounds useful for the treatment of parasitic disease.
摘要翻译： 用于治疗寄生虫病的高度N-甲基化线性脂肽化合物的新型结构类。
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公开(公告)号：US20160200763A1
公开(公告)日：2016-07-14
申请号：US14392205
申请日：2014-06-24
CPC分类号： C07K7/06 , A61K38/00 , A61K38/08 , A61K38/10 , C07K7/08 , C40B30/02 , G06F19/16 , Y02A50/401 , Y02A50/409 , Y02A50/411 , Y02A50/414 , Y02A50/415 , Y02A50/419 , Y02A50/422 , Y02A50/423 , Y02A50/491
摘要： Novel peptide inhibitors of GSK-3, compositions containing same and uses thereof are disclosed. The novel peptide inhibitors are converted to inhibitors of GSK-3 upon interacting with the enzyme's catalytic site and hence act as disease-selective inhibitors for treating conditions associated with increased activity and/or expression of GSK-3. Each of the disclosed peptides is independently of no more than 15 amino acid residues, and has an amino acid sequence which comprises a ZX1X2X3Z(p) recognition motif of GSK-3, wherein Z(p) is a phosphorylated serine or threonine residue; Z is a phosphorylatable serine or threonine residue, and each of X1, X2 and X3 is independently any amino acid, as defined in the specification. Further disclosed are methods of identifying a putative substrate-competitive peptide inhibitor of GSK-3 which are effected by computational modeling and screening.
摘要翻译： 公开了GSK-3的新型肽抑制剂，含有其的组合物及其用途。 当与酶的催化位点相互作用时，新型肽抑制剂被转化为GSK-3的抑制剂，因此作为用于治疗与增加的GSK-3的活性和/或表达相关的病症的疾病选择性抑制剂。 所公开的肽各自独立地不超过15个氨基酸残基，并且具有包含GSK-3的ZX1X2X3Z（p）识别基序的氨基酸序列，其中Z（p）是磷酸化丝氨酸或苏氨酸残基; Z是可磷酸化的丝氨酸或苏氨酸残基，X1，X2和X3各自独立地是任何氨基酸，如说明书中所定义的。 进一步公开的是鉴定GSK-3的推定的底物竞争性肽抑制剂的方法，其通过计算建模和筛选来实现。
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公开(公告)号：US09017732B1
公开(公告)日：2015-04-28
申请号：US14563829
申请日：2014-12-08
CPC分类号： A61K35/62 , A01K67/033 , A01N63/00 , A61K9/0014 , A61K31/282 , A61K31/4745 , A61K31/555 , A61K38/21 , A61K45/06 , Y02A50/385 , Y02A50/387 , Y02A50/393 , Y02A50/40 , Y02A50/401 , Y02A50/402 , Y02A50/406 , Y02A50/409 , Y02A50/411 , Y02A50/414 , Y02A50/415 , Y02A50/419 , Y02A50/422 , Y02A50/423 , Y02A50/463 , Y02A50/465 , Y02A50/467 , Y02A50/469 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/479 , Y02A50/481 , Y02A50/483 , Y02A50/491 , A61K2300/00
摘要： Methods are provided for isolating and using a whole-saliva leech extract. The methods can include feeding a phagostimulatory agent to a leech; inducing a regurgitation in the leech, the inducing including placing the leech in an environment having a temperature of less than about 0° C.; and, collecting an unrefined, whole saliva in the regurgitation of the cooled leech. The methods can include revitalizing the leech by warming it at a temperature ranging from about 5° C. to about 40° C. Stable, lyophilized, whole-saliva extracts of a leech are also provided, the extract having a stable activity when stored for use at a temperature below about −20° C., the extract maintaining at least 70% of the activity for at least 6 months. The extracts can be used to treat solid tumors, treat liquid tumors, treat diabetes, treat a viral disease, treat a parasitic disease, treat an antibacterial disease, or serve as an anti-oxidant.
摘要翻译： 提供了分离和使用全唾液水蛭提取物的方法。 所述方法可以包括向水蛭喂养吞噬剂; 诱导水蛭反流，诱导包括将水蛭放置在温度低于约0℃的环境中; 并在冷水蛭的反流中收集未精制的全唾液。 所述方法可以包括通过在约5℃至约40℃的温度范围内升温来振兴水蛭。还提供了稳定的，冻干的全唾液提取物，所述提取物在储存时具有稳定的活性 在低于约-20℃的温度下使用，提取物保持至少6个月的活性的至少70％。 提取物可用于治疗实体瘤，治疗液体肿瘤，治疗糖尿病，治疗病毒性疾病，治疗寄生虫病，治疗抗菌疾病或用作抗氧化剂。
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公开(公告)号：US09005667B1
公开(公告)日：2015-04-14
申请号：US14552388
申请日：2014-11-24
IPC分类号： A61K35/37 , A61K38/00 , A61K31/4745 , A61K31/555 , A61K35/62
CPC分类号： A61K35/62 , A01K67/033 , A01N63/00 , A61K9/0014 , A61K31/282 , A61K31/4745 , A61K31/555 , A61K38/21 , A61K45/06 , Y02A50/385 , Y02A50/387 , Y02A50/393 , Y02A50/40 , Y02A50/401 , Y02A50/402 , Y02A50/406 , Y02A50/409 , Y02A50/411 , Y02A50/414 , Y02A50/415 , Y02A50/419 , Y02A50/422 , Y02A50/423 , Y02A50/463 , Y02A50/465 , Y02A50/467 , Y02A50/469 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/479 , Y02A50/481 , Y02A50/483 , Y02A50/491 , A61K2300/00
摘要： Methods are provided for isolating and using a whole-saliva leech extract. The methods can include feeding a phagostimulatory agent to a leech; inducing a regurgitation in the leech, the inducing including placing the leech in an environment having a temperature of less than about 0° C.; and, collecting an unrefined, whole saliva in the regurgitation of the cooled leech. The methods can include revitalizing the leech by warming it at a temperature ranging from about 5° C. to about 40° C. Stable, lyophilized, whole-saliva extracts of a leech are also provided, the extract having a stable activity when stored for use at a temperature below about −20° C., the extract maintaining at least 70% of the activity for at least 6 months. The extracts can be used to treat solid tumors, treat liquid tumors, treat diabetes, treat a viral disease, treat a parasitic disease, treat an antibacterial disease, or serve as an anti-oxidant.
摘要翻译： 提供了分离和使用全唾液水蛭提取物的方法。 所述方法可以包括向水蛭喂养吞噬剂; 诱导水蛭反流，诱导包括将水蛭放置在温度低于约0℃的环境中; 并在冷水蛭的反流中收集未精制的全唾液。 所述方法可以包括通过在约5℃至约40℃的温度范围内升温来振兴水蛭。还提供了稳定的，冻干的全唾液提取物，所述提取物在储存时具有稳定的活性 在低于约-20℃的温度下使用，提取物保持至少6个月的活性的至少70％。 提取物可用于治疗实体瘤，治疗液体肿瘤，治疗糖尿病，治疗病毒性疾病，治疗寄生虫病，治疗抗菌疾病或用作抗氧化剂。
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公开(公告)号：US20130259955A1
公开(公告)日：2013-10-03
申请号：US13767959
申请日：2013-02-15
申请人： Yongge Chen , Roberto De Noni , Giorgio Reiner , Paolo Galfetti
发明人： Yongge Chen , Roberto De Noni , Giorgio Reiner , Paolo Galfetti
IPC分类号： A61K33/20
CPC分类号： A61K33/20 , A01N59/00 , Y02A50/385 , Y02A50/387 , Y02A50/401 , Y02A50/402 , Y02A50/406 , Y02A50/409 , Y02A50/414 , Y02A50/419 , Y02A50/422 , Y02A50/423 , Y02A50/465 , Y02A50/469 , Y02A50/47 , Y02A50/471 , Y02A50/478 , Y02A50/483 , Y02A50/491 , A01N2300/00 , A01N25/00
摘要： The present invention relates to methods of treating or preventing an infection or infectious disease in a mammal, or sanitizing mammalian tissue, or treating or preventing psoriasis in a mammal, comprising topically administering to said mammal an electrolytic acid water comprising free chlorine, wherein: a) from 90% to 99.9% of said free chlorine is present in the form of hypochlorous acid; b) said water has a pH of from 0.5 to 5.0; and c) said water has oxidation reduction potential (ORP) of greater than 1100 mV. The present invention also relates to methods of healing, repair or regeneration of a tissue in a mammal comprising topically administering to said tissue said electrolytic acid water.
摘要翻译： 本发明涉及治疗或预防哺乳动物感染或感染性疾病或消毒哺乳动物组织，或治疗或预防哺乳动物中牛皮癣的方法，包括向所述哺乳动物施用包含游离氯的电解酸水，其中：a ）从90％至99.9％的所述游离氯以次氯酸的形式存在; b）所述水的pH为0.5-5.0; 和c）所述水具有大于1100mV的氧化还原电位（ORP）。 本发明还涉及哺乳动物组织的愈合，修复或再生的方法，包括向所述组织局部施用所述电解酸水。
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公开(公告)号：US20120316248A1
公开(公告)日：2012-12-13
申请号：US13592127
申请日：2012-08-22
申请人： Essam Enan
发明人： Essam Enan
CPC分类号： A61K31/05 , A61K31/085 , Y02A50/409 , Y02A50/411 , Y02A50/419 , Y02A50/421 , Y02A50/423 , Y02A50/491 , A61K2300/00
摘要： Compositions for treating parasitic infections and methods of using the compositions to treat subjects with parasitic infections are provided. Methods of selecting compositions for use in treating parasitic infections are further provided.
摘要翻译： 提供了用于治疗寄生虫感染的组合物和使用该组合物治疗寄生虫感染受试者的方法。 还提供了选择用于治疗寄生虫感染的组合物的方法。
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公开(公告)号：US20120177656A1
公开(公告)日：2012-07-12
申请号：US13376687
申请日：2010-06-11
IPC分类号： A61K39/395 , A61K31/05 , A61P33/10 , A61K31/713 , A61K31/7105 , A61P35/00 , A61K31/4164 , A61K38/44
CPC分类号： A61K31/4164 , A61K31/05 , A61K45/06 , Y02A50/419 , Y02A50/421 , Y02A50/422 , Y02A50/423
摘要： Methods for regulating the formation of a sulfilimine crosslink in a subject by administering a sulfilimine crosslink modulator are disclosed The sulfilimine modulator may inhibit or create a sulfilimine crosslink and maybe useful for treating a disease, such as cancer The sulfilimine crosslink may be between two or more peptides
摘要翻译： 公开了通过施用亚硫酰亚胺交联调节剂调节受试者中亚硫酰亚胺交联形成的方法。亚硫酰亚胺调节剂可以抑制或产生亚硫酰亚胺交联，并且可用于治疗疾病如癌症。亚硫酰亚胺交联可以在两个或更多个之间 肽
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公开(公告)号：US20170360881A1
公开(公告)日：2017-12-21
申请号：US15625672
申请日：2017-06-16
发明人： Manoj Samant , Krzysztof Darlak , Eric Feyfant , Steve DeMarco
CPC分类号： A61K38/12 , A61K45/06 , Y02A50/385 , Y02A50/397 , Y02A50/401 , Y02A50/402 , Y02A50/409 , Y02A50/411 , Y02A50/415 , Y02A50/419 , Y02A50/422 , Y02A50/463 , Y02A50/47 , Y02A50/473 , Y02A50/478 , Y02A50/479 , Y02A50/491
摘要： Provided herein are peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disorders, for example, for treatment of infectious diseases.
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公开(公告)号：US20160331803A1
公开(公告)日：2016-11-17
申请号：US15111550
申请日：2015-01-23
发明人： Randolph J. NOELLE , Sabrina CEERAZ , Isabelle LEMERCIER , Elizabeth NOWAK , Janet LINES , Li WANG , Mark SPALLER
IPC分类号： A61K38/10 , G01N33/566 , A61K9/00 , C07K7/08 , A61K45/06
CPC分类号： A61K38/10 , A61K9/0019 , A61K38/00 , A61K45/06 , C07K7/08 , C07K2319/30 , Y02A50/385 , Y02A50/387 , Y02A50/393 , Y02A50/402 , Y02A50/409 , Y02A50/411 , Y02A50/419 , Y02A50/421 , Y02A50/423 , Y02A50/463 , Y02A50/465 , Y02A50/467 , Y02A50/475 , Y02A50/478 , Y02A50/491 , Y02A50/58
摘要： The present invention is directed to a peptide, multimer, conjugate, analog, derivative or mimetic thereof that inhibits the activity of VISTA. The invention further contemplates therapeutic use of the VISTA antagonist peptide, multimer, conjugate, derivative or mimetic thereof, including treating or preventing cancer, bacterial infections, viral infections, parasitic infections and fungal infections, as well as research uses of the antagonist.
摘要翻译： 本发明涉及抑制VISTA活性的肽，多聚体，缀合物，类似物，衍生物或模拟物。 本发明进一步考虑了VISTA拮抗剂肽，多聚体，缀合物，衍生物或其模拟物的治疗用途，包括治疗或预防癌症，细菌感染，病毒感染，寄生虫感染和真菌感染以及拮抗剂的研究用途。
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