公开(公告)号：US20160311838A1

公开(公告)日：2016-10-27

申请号：US15026670

申请日：2014-10-02

Applicant: THE TRUSTEES OF PRINCETON UNIVERSITY

Inventor： Tom W. Muir ,  Rob C. Oslund ,  Jung-Min Kee

IPC: C07F9/6503 ,  G01N33/53 ,  C07K16/44

CPC classification number: C07F9/65031 ,  C07K16/44 ,  G01N33/5308 ,  G01N2800/26

Abstract: Provided are phosphonopyrazole-based phosphohistidine analogs that are useful as haptens for the preparation of immunogens, immunogens that include these haptens linked to carrier molecules, antibodies thereto and uses of these antibodies, haptens, immunogens and phosphohistidine analogs. The invention is based in part on new pHis analogs that are chemically stable and which have been used as haptens and immunogens to generate specific anti-pHis antibodies that bind with high affinity and specificity.

Abstract translation: 提供了可用作制备免疫原的半抗原的基于膦酰吡唑的磷酸组氨酸类似物，包括与载体分子连接的这些半抗原的免疫原，其抗体及其抗体，半抗原，免疫原和磷酸组氨酸类似物的用途。 本发明部分基于化学稳定的新的pH值类似物，并且其已被用作半抗原和免疫原以产生以高亲和性和特异性结合的特异性抗pH值抗体。

公开(公告)号：US20220220134A1

公开(公告)日：2022-07-14

申请号：US17707330

申请日：2022-03-29

Applicant: The Trustees of Princeton University

Inventor： Tom W. Muir ,  Rob C. Oslund ,  Jung-Min Kee

IPC: C07F9/6503 ,  G01N33/53 ,  C07K16/44

Abstract: Provided are phosphonopyrazole-based phosphohistidine analogs that are useful as haptens for the preparation of immunogens, immunogens that include these haptens linked to carrier molecules, antibodies thereto and uses of these antibodies, haptens, immunogens and phosphohistidine analogs.

公开(公告)号：US10351581B2

公开(公告)日：2019-07-16

申请号：US15026670

申请日：2014-10-02

Applicant: The Trustees of Princeton University

Inventor： Tom W. Muir ,  Rob C. Oslund ,  Jung-Min Kee

IPC: C07F9/6503 ,  C07K16/44 ,  G01N33/53

Abstract: Provided are phosphonopyrazole-based phosphohistidine analogs that are useful as haptens for the preparation of immunogens, immunogens that include these haptens linked to carrier molecules, antibodies thereto and uses of these antibodies, haptens, immunogens and phosphohistidine analogs. The invention is based in part on new pHis analogs that are chemically stable and which have been used as haptens and immunogens to generate specific anti-pHis antibodies that bind with high affinity and specificity.

公开(公告)号：US12168671B2

公开(公告)日：2024-12-17

申请号：US17707330

申请日：2022-03-29

Applicant: The Trustees of Princeton University

Inventor： Tom W. Muir ,  Rob C. Oslund ,  Jung-Min Kee

IPC: C07F9/6503 ,  C07K16/44 ,  G01N33/53

Abstract: Provided are phosphonopyrazole-based phosphohistidine analogs that are useful as haptens for the preparation of immunogens, immunogens that include these haptens linked to carrier molecules, antibodies thereto and uses of these antibodies, haptens, immunogens and phosphohistidine analogs.

公开(公告)号：US20190092796A1

公开(公告)日：2019-03-28

申请号：US16135396

申请日：2018-09-19

Applicant: The Trustees of Princeton University

Inventor： Tom W. Muir ,  Rob C. Oslund ,  Jung-Min Kee

IPC: C07F9/6503 ,  G01N33/53 ,  C07K16/44

Abstract: Provided are phosphonopyrazole-based phosphohistidine analogs that are useful as haptens for the preparation of immunogens, immunogens that include these haptens linked to carrier molecules, antibodies thereto and uses of these antibodies, haptens, immunogens and phosphohistidine analogs.