公开(公告)号：US20140207248A1

公开(公告)日：2014-07-24

申请号：US14157602

申请日：2014-01-17

Applicant: THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY

Inventor： Hongjun Wang ,  Gerald Riccardello ,  Jiale Li

IPC: A61F2/02

CPC classification number: A61L27/50 ,  A61L27/56 ,  A61L2400/12 ,  D01D5/0007 ,  D01D5/0084 ,  D04H1/728 ,  D04H3/016 ,  D04H3/04 ,  D04H3/05

Abstract: A hierarchical multiscale fibrous scaffold comprises multiple patterned layers of microfibers with one or more layers of nanofibers interleaved therebetween. In a method for making such scaffolds, electrodeposition or near-field electrospinning is used to deposit patterned layers of microfibers in a stack. Conventional electrospinning is used to deposit nanofibers on the layers of microfibers. The method may be used to tune the mechanical properties of the scaffold, facilitated by microfibers, and the biological features of the scaffold, facilitated by nanofibers. Scaffolds produced by such a process may have highly biomimetic architectures, and allow rapid cellular infiltration and sustainable cell growth for multiple tissue types.

Abstract translation: 分级多尺度纤维支架包括多个图案化的微纤维层，其间具有交织的一层或多层纳米纤维。 在制造这种支架的方法中，使用电沉积或近场静电纺丝将堆叠中的微纤维的图案化层沉积。 常规静电纺丝用于在微纤维层上沉积纳米纤维。 该方法可用于调节由微纤维促进的支架的机械性能以及由纳米纤维促进的支架的生物学特征。 通过这种方法生产的支架可具有高度仿生结构，并允许多种组织类型的快速细胞浸润和可持续的细胞生长。