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1.发明申请公开(公告)号：US20170088815A1
公开(公告)日：2017-03-30
申请号：US15086896
申请日：2016-03-31
Inventor： Hongjun Wang , Chao Jia
IPC: C12N5/00
CPC classification number: C12N5/0691 , C12N5/069 , C12N2501/115 , C12N2501/135 , C12N2501/165 , C12N2513/00 , C12N2533/30 , C12N2533/54 , C12N2535/00
Abstract: The present disclosure relates to fabricating sacrificial microfiber templates from any biocompatible and resorbable materials depending on the time needed for dissolving the microfiber template to free the endothelial tube with open lumen. Microfiber networks with distinct patterns and defined diameters initially serve as a template to support the growth of vascular cells (endothelial cells or their progenitor cells, or combined with mural cells such as pericytes) and then dissolve to form an empty endothelium lumen. The incorporation of sacrificial microfiber networks encapsulated with vascular cells into 3D cell-rich constructs allows for the creation of various vascularized tissues.
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公开(公告)号：US20230302199A1
公开(公告)日：2023-09-28
申请号：US18117320
申请日：2023-03-03
Inventor： Hongjun Wang , Meng Xu , Deep Parikh , Jin Zou , Weiwei Wang
IPC: A61L27/36 , A61L27/56 , G01N33/50 , C12N5/00 , A61L27/54 , A61L27/18 , A61L27/52 , A61L27/58 , A61L27/60
CPC classification number: A61L27/3691 , A61L27/3604 , A61L27/56 , G01N33/5011 , C12N5/0062 , G01N33/5082 , A61L27/54 , A61L27/18 , A61L27/52 , A61L27/58 , A61L27/3608 , A61L27/60 , A61L27/365 , A61L27/3666 , C12N5/0075 , C12N2533/00 , C12N2539/00 , C12N2533/30 , A61L2430/28 , A61L2430/02 , C12N2500/84 , C12N2513/00 , C12N2503/02 , C12N2533/74
Abstract: In accordance with the method of the present invention, 3D tissue-derived scaffolding materials are made in various formats, including but not limited to hydrogel, sponge, fibers, microspheres, and films, all of which function to better preserve natural extracellular matrix molecules and to mimic the natural tissue environment, thereby effectively guiding tissue regeneration. The method involves incorporating a homogenized tissue-derived suspension into a polymeric solution of synthetic, natural, or hybrid polymers to prepare tissue-derived scaffolds in the aforementioned formats. Such tissue-derived scaffolds and scaffolding materials have a variety of utilities, including: the creation of 3D tissue models such as skin, bone, liver, pancreas, lung, and so on; facilitation of studies on cell-matrix interactions; and the fabrication of implantable scaffolding materials for guided tissue formation in vivo. The tissue-derived scaffolds and scaffolding materials made in accordance with the present invention also provide the opportunity to correlate the functions of extracellular matrix with tissue regeneration and cancer metastasis, for example.
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3.发明申请MODIFICATION OF ROOT FORM DENTAL IMPLANTS FOR ACCELERATED TISSUE REGENERATION 审中-公开用于加速组织再生的牙根形态植入物的修改公开(公告)号：US20140205971A1
公开(公告)日：2014-07-24
申请号：US14158291
申请日：2014-01-17
Inventor： Hongjun Wang
CPC classification number: A61C13/0006 , A61C8/0022 , A61C2202/00
Abstract: An endosseous dental implant for guided regeneration of gingival tissue onto the implant and method of producing the same is prepared by coating a region of the implant with biocompatible, random or aligned microfibers or nanofibers to which gingival epithelial and connective tissue cells may become attached. The fibers may be degradable or nondegradable. The extracellular matrix of new connective tissue forms and connects to the implant surface, guided by the nanofibers or microfibers. The coated implant prevents bacterial biofilm formation, which can cause detrimental resorption of crestal bone and lead to implant failure. The implant surface supports improved tissue bonding and provides a cost-effective approach to coating the dental implant surface with biomimetic fibers to enhance gingival or other tissue regeneration directly onto the implant surface.
Abstract translation: 通过用生物相容性，随机或排列的微纤维或纳米纤维涂覆牙龈上皮和结缔组织细胞可能附着的植入物的区域来制备用于将牙龈组织引导再生到植入物上的内骨牙植入物及其制备方法。 纤维可以是可降解的或不可降解的。 新结缔组织的细胞外基质在纳米纤维或微纤维引导下形成并连接到植入物表面。 涂覆的植入物防止细菌生物膜形成，其可引起冠状骨的有害吸收并导致植入物失效。 植入物表面支持改进的组织粘合，并且提供了一种经济有效的方法来用仿生纤维涂覆牙齿植入物表面，以将牙龈或其他组织再生直接施加到植入物表面上。
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公开(公告)号：US20230293179A1
公开(公告)日：2023-09-21
申请号：US18020049
申请日：2021-08-06
Inventor： Hongjun Wang , Haoyu Wang , Juan Wang
IPC: A61B17/11 , A61L31/10 , A61L31/06 , A61L31/14 , B41M5/00 , B33Y10/00 , B33Y40/20 , B33Y80/00 , B33Y70/00
CPC classification number: A61B17/1128 , A61L31/10 , A61L31/06 , A61L31/14 , B41M5/0047 , B33Y10/00 , B33Y40/20 , B33Y80/00 , B33Y70/00 , A61B2017/00526
Abstract: The present invention relates generally to the manufacture of conductive scaffolds of micro and/or nanofibers with the help of different printing techniques (e.g., near-field electrostatic printing, inkjet printing), such scaffolds enabling the formation of two-dimensional (2D) or three-dimensional (3D) neural networks to mimic the native counterparts. Applications of such patterned conductive scaffolds include, but are not limited to, an engineered conduit for guiding the differentiation and outgrowth of neural cells in peripheral nerve damage or in large-volume spinal cord injury under the electrical stimulation. Meanwhile, the scaffolds could also locally deliver various biomolecules in conjunction with electrical stimulation for facilitated nervous system regeneration (FIG. 1).
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公开(公告)号：US10184113B2
公开(公告)日：2019-01-22
申请号：US14973329
申请日：2015-12-17
Applicant: Hackensack University Medical Center , The Trustees of The Stevens Institute of Technology
Inventor： Woo Lee , Jenny Zilberberg , David Samuel Siegel , Peter Tolias , Hongjun Wang , Wenting Zhang
IPC: C12M3/06 , C12N5/09 , G01N33/50 , G01N33/574
Abstract: The described invention provides an ex vivo dynamic multiple myeloma (MM) cancer niche contained in a microfluidic device. The dynamic MM cancer niche includes (a) a three-dimensional tissue construct containing a dynamic ex vivo bone marrow (BM) niche, which contains a mineralized bone-like tissue containing viable osteoblasts self-organized into cohesive multiple cell layers and an extracellular matrix secreted by the viable adherent osteoblasts; and a microenvironment dynamically perfused by nutrients and dissolved gas molecules; and (b) human myeloma cells seeded from a biospecimen composition comprising mononuclear cells and the multiple myeloma cells. The human myeloma cells are in contact with osteoblasts of the BM niche, and the viability of the human myeloma cells is maintained by the MM cancer niche.
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Patent Agency Ranking
6.发明授权Ex vivo human multiple myeloma cancer niche and its use as a model for personalized treatment of multiple myeloma 有权离体人多发性骨髓瘤癌症利基及其作为个体化治疗多发性骨髓瘤的模型公开(公告)号：US09267938B2
公开(公告)日：2016-02-23
申请号：US13827170
申请日：2013-03-14
Applicant: The Trustees of the Stevens Institute of Technology , Hackensack University Medical Center
Inventor： Woo Lee , Jenny Zilberberg , David Samuel Siegel , Peter Tolias , Hongjun Wang , Wenting Zhang
IPC: G01N33/50 , G01N33/574
CPC classification number: C12N5/0694 , G01N33/5091 , G01N33/574 , G01N2500/10 , G01N2510/00 , G01N2800/52 , G01N2800/7028
Abstract: The described invention provides an ex vivo dynamic multiple myeloma (MM) cancer niche contained in a microfluidic device. The dynamic MM cancer niche includes (a) a three-dimensional tissue construct containing a dynamic ex vivo bone marrow (BM) niche, which contains a mineralized bone-like tissue containing viable osteoblasts self-organized into cohesive multiple cell layers and an extracellular matrix secreted by the viable adherent osteoblasts; and a microenvironment dynamically perfused by nutrients and dissolved gas molecules; and (b) human myeloma cells seeded from a biospecimen composition comprising mononuclear cells and the multiple myeloma cells. The human myeloma cells are in contact with osteoblasts of the BM niche, and the viability of the human myeloma cells is maintained by the MM cancer niche.
Abstract translation: 所述发明提供了包含在微流体装置中的离体动态多发性骨髓瘤（MM）癌症小生境。 动态MM癌症利基包括（a）含有动态离体骨髓（BM）利基的三维组织构建体，其包含自体组织成粘性多细胞层的活性成骨细胞的矿化骨样组织和细胞外基质 由可行的粘附成骨细胞分泌; 和营养物质和溶解气体分子动态灌注的微环境; 和（b）从包含单核细胞和多发性骨髓瘤细胞的生物壳组合物接种的人骨髓瘤细胞。 人骨髓瘤细胞与BM细菌的成骨细胞接触，并且通过MM癌症细菌保持人骨髓瘤细胞的存活力。
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公开(公告)号：US11612676B2
公开(公告)日：2023-03-28
申请号：US15885408
申请日：2018-01-31
Inventor： Hongjun Wang , Meng Xu , Deep Parikh , Jin Zou , Weiwei Wang
IPC: A61L27/36 , A61L27/56 , G01N33/50 , C12N5/00 , A61L27/54 , A61L27/18 , A61L27/52 , A61L27/58 , A61L27/60
Abstract: 3D native tissue-derived scaffolding materials are made in various formats, including but not limited to hydrogel, sponge, fibers, microspheres, and films, all of which function to better preserve natural extracellular matrix molecules and to recapitulate the natural tissue environment, thereby effectively guiding tissue regeneration. Tissue-derived scaffolds are prepared by incorporating a homogenized tissue-derived suspension into a polymeric solution of synthetic, natural, or hybrid polymers. Such tissue-derived scaffolds and scaffolding materials have a variety of utilities, including: the creation of 3D tissue models such as skin, bone, liver, pancreas, lung, and so on; facilitation of studies on cell-matrix interactions; and the fabrication of implantable scaffolding materials for guided tissue formation in vivo. The tissue-derived scaffolds and scaffolding materials also provide the opportunity to correlate the functions of extracellular matrix with tissue regeneration and cancer metastasis, for example.
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公开(公告)号：US09458568B2
公开(公告)日：2016-10-04
申请号：US14545569
申请日：2015-05-22
Inventor： Chao Jia , Hongjun Wang
Abstract: A method for fabricating a patterned fibrous matrix includes providing a printer adapted to use an etching solvent as an ink; providing to the printer a fibrous matrix to use as a printing medium; providing to the printer a pattern for printing on the fibrous matrix; printing by the printer the pattern on the fibrous matrix; and receiving from the printer the patterned fibrous matrix with the pattern etched thereon.
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9.发明申请Creation of patterns in fibrous matrices using localized dissolution printing 有权使用局部溶解印刷法在纤维基质中形成图案公开(公告)号：US20150337489A1
公开(公告)日：2015-11-26
申请号：US14545569
申请日：2015-05-22
Inventor： Chao Jia , Hongjun Wang
IPC: D06Q1/02
Abstract: A method for fabricating a patterned fibrous matrix includes providing a printer adapted to use an etching solvent as an ink; providing to the printer a fibrous matrix to use as a printing medium; providing to the printer a pattern for printing on the fibrous matrix; printing by the printer the pattern on the fibrous matrix; and receiving from the printer the patterned fibrous matrix with the pattern etched thereon.
Abstract translation: 制造图案化纤维基质的方法包括提供适于使用蚀刻溶剂作为油墨的打印机; 向打印机提供用作打印介质的纤维基质; 向打印机提供在纤维基质上印刷的图案; 由打印机打印出纤维矩阵上的图案; 并从打印机接收图案化的纤维基质，其上刻有图案。
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公开(公告)号：US20180214610A1
公开(公告)日：2018-08-02
申请号：US15885408
申请日：2018-01-31
Inventor： Hongjun Wang , Meng Xu , Deep Parikh , Jin Zou , Weiwei Wang
CPC classification number: A61L27/3691 , A61L27/18 , A61L27/3604 , A61L27/3608 , A61L27/365 , A61L27/3666 , A61L27/52 , A61L27/54 , A61L27/56 , A61L27/58 , A61L27/60 , A61L2430/02 , A61L2430/28 , C12N5/0062 , C12N5/0075 , C12N2500/84 , C12N2503/02 , C12N2513/00 , C12N2533/00 , C12N2533/30 , C12N2533/74 , C12N2539/00 , G01N33/5011 , G01N33/5082 , C08L67/04
Abstract: In accordance with the method of the present invention, 3D tissue-derived scaffolding materials are made in various formats, including but not limited to hydrogel, sponge, fibers, microspheres, and films, all of which function to better preserve natural extracellular matrix molecules and to mimic the natural tissue environment, thereby effectively guiding tissue regeneration. The method involves incorporating a homogenized tissue-derived suspension into a polymeric solution of synthetic, natural, or hybrid polymers to prepare tissue-derived scaffolds in the aforementioned formats. Such tissue-derived scaffolds and scaffolding materials have a variety of utilities, including: the creation of 3D tissue models such as skin, bone, liver, pancreas, lung, and so on; facilitation of studies on cell-matrix interactions; and the fabrication of implantable scaffolding materials for guided tissue formation in vivo. The tissue-derived scaffolds and scaffolding materials made in accordance with the present invention also provide the opportunity to correlate the functions of extracellular matrix with tissue regeneration and cancer metastasis, for example.
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