-
公开(公告)号：US20210253683A1
公开(公告)日：2021-08-19
申请号：US17243455
申请日：2021-04-28
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC , Sanaria Inc.
发明人： Robert Seder , Neville Kisalu , Azza Idris , Barbara Flynn , Stephen Hoffman
IPC分类号： C07K16/20
摘要： Antibodies and antigen binding fragments that specifically bind to P. falciparum circumsporozoite protein and neutralize P. falciparum are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. The disclosed antibodies, antigen binding fragments, nucleic acids and vectors can be used, for example, to inhibit a P. falciparum infection.
-
公开(公告)号：US20210023208A1
公开(公告)日：2021-01-28
申请号：US17064496
申请日：2020-10-06
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic , The Chancellor, Masters and Scholars of the University of Oxford
发明人： Robert Seder , Geoffrey Lynn , Leonard Seymour
摘要： Embodiments of a novel system for delivering an expression vector encoding an antigen to a subject that allows for spatiotemporal control over stimulation of the subject's immune response to the antigen are provided. In some embodiments, the expression vector delivery system includes a polymer linked to an adjuvant in prodrug form that can form polymer nanoparticles and enter a cell (such as an immune cell) under physiological conditions. In some embodiments, the adjuvant is linked to the polymer by an enzyme degradable labile bond, the cleavage of which activates the adjuvant to stimulate an immune response.
-
公开(公告)号：US20220152170A1
公开(公告)日：2022-05-19
申请号：US17517597
申请日：2021-11-02
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic
发明人： Robert Seder , Geoffrey Lynn
摘要： Embodiments of a novel platform for delivering a peptide antigen to a subject to induce an immune response to the peptide antigen are provided. For example, nanoparticle polyplexes are provided that comprise a polymer linked to a peptide conjugate by an electrostatic interaction. The conjugate comprises a peptide antigen linked to a peptide tag through an optional linker. An adjuvant may be included in the nanoparticle polyplex, linked to either the polymer or the conjugate, or admixed with the nanoparticles. The nanoparticle polyplex can be administered to a subject to induce an immune response to the peptide antigen.
-
公开(公告)号：US11760794B2
公开(公告)日：2023-09-19
申请号：US17243455
申请日：2021-04-28
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , Sanaria Inc.
发明人： Robert Seder , Neville Kisalu , Azza Idris , Barbara Flynn , Stephen Hoffman
IPC分类号： C07K16/20
CPC分类号： C07K16/205 , C07K2317/21 , C07K2317/34 , C07K2317/76 , C07K2317/92
摘要： Antibodies and antigen binding fragments that specifically bind to P. falciparum circumsporozoite protein and neutralize P. falciparum are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. The disclosed antibodies, antigen binding fragments, nucleic acids and vectors can be used, for example, to inhibit a P. falciparum infection.
-
公开(公告)号：US11021535B2
公开(公告)日：2021-06-01
申请号：US16485354
申请日：2018-02-12
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , SANARIA INC
发明人： Robert Seder , Neville Kisalu , Azza Idris , Barbara Flynn , Stephen Hoffman
IPC分类号： C07K16/20
摘要： Antibodies and antigen binding fragments that specifically bind to P. falciparum circumsporozoite protein and neutralize P. falciparum are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. The disclosed antibodies, antigen binding fragments, nucleic acids and vectors can be used, for example, to inhibit a P. falciparum infection.
-
6.发明授权公开(公告)号：US10197577B2
公开(公告)日：2019-02-05
申请号：US15858560
申请日：2017-12-29
申请人： Sanaria Inc. , Antigen Discovery, Inc. , The United States of America, as represented by the Secretary, Department of Health and Human Services
IPC分类号： A61K39/00 , G01N33/68 , A61K39/015 , G01N33/569
摘要： Disclosed herein are diagnostic methods and compositions for identifying individuals that are protected against Plasmodium falciparum caused malaria. Such methods are particularly useful for determining not only the protective efficacy of Pf whole parasite vaccines for individual subjects, but also within populations of vaccinated subjects. Also disclosed herein are subunit vaccines comprising at least one Pf immunologic determinant for protection against Plasmodium-caused malaria.
-
7.发明公开公开(公告)号：US20240117026A1
公开(公告)日：2024-04-11
申请号：US18364104
申请日：2023-08-02
申请人： The U.S.A., as Represented by the Secretary, Department of Health and Human Services , Sanaria Inc.
发明人： Robert Seder , Neville Kisalu , Azza Idris , Barbara Flynn , Stephen Hoffman
IPC分类号： C07K16/20
CPC分类号： C07K16/205 , C07K2317/21 , C07K2317/34 , C07K2317/76 , C07K2317/92
摘要： Antibodies and antigen binding fragments that specifically bind to P. falciparum circumsporozoite protein and neutralize P. falciparum are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. The disclosed antibodies, antigen binding fragments, nucleic acids and vectors can be used, for example, to inhibit a P. falciparum infection.
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.034 秒)
