公开(公告)号：US20210253683A1

公开(公告)日：2021-08-19

申请号：US17243455

申请日：2021-04-28

申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC ,  Sanaria Inc.

发明人： Robert Seder ,  Neville Kisalu ,  Azza Idris ,  Barbara Flynn ,  Stephen Hoffman

IPC分类号： C07K16/20

摘要： Antibodies and antigen binding fragments that specifically bind to P. falciparum circumsporozoite protein and neutralize P. falciparum are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. The disclosed antibodies, antigen binding fragments, nucleic acids and vectors can be used, for example, to inhibit a P. falciparum infection.

公开(公告)号：US20240117026A1

公开(公告)日：2024-04-11

申请号：US18364104

申请日：2023-08-02

申请人： The U.S.A., as Represented by the Secretary, Department of Health and Human Services ,  Sanaria Inc.

发明人： Robert Seder ,  Neville Kisalu ,  Azza Idris ,  Barbara Flynn ,  Stephen Hoffman

IPC分类号： C07K16/20

CPC分类号： C07K16/205 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92

摘要： Antibodies and antigen binding fragments that specifically bind to P. falciparum circumsporozoite protein and neutralize P. falciparum are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. The disclosed antibodies, antigen binding fragments, nucleic acids and vectors can be used, for example, to inhibit a P. falciparum infection.

公开(公告)号：US11503819B2

公开(公告)日：2022-11-22

申请号：US16995164

申请日：2020-08-17

申请人： Sanaria Inc. ,  The Johns Hopkins University

发明人： Russell H. Taylor ,  Gregory Chirikjian ,  Iulian Iordachita ,  Henry Phalen ,  Hongtao Wu ,  Mengdi Xu ,  Shengnan Lu ,  Michael Aaron Pozin ,  Jin Seob Kim ,  Can Kocabalkanli ,  Balazs Vagvolgyi ,  Brian K. Chirikjian ,  Joshua Davis ,  Ting Da ,  John S. Chirikjian ,  Sumana Chakravarty ,  Stephen Hoffman

IPC分类号： A61B10/00 ,  A01M1/02 ,  B01L9/00

摘要： Systems and methods for providing a combined mosquito staging and dissection system are disclosed. The system can include a mosquito staging subsystem; a robotic pick-and-place station; and a dissection, extrusion, collection, and disposal subsystem. The subsystems can include one or more stations to provide orientation, decapitation, extrusion of salivary glands, and disposal of carcasses of the mosquitoes. The resident live sporozoites from the salivary glands can be used to produce Plasmodium SPZ-based vaccines.

公开(公告)号：US11021535B2

公开(公告)日：2021-06-01

申请号：US16485354

申请日：2018-02-12

申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES ,  SANARIA INC

发明人： Robert Seder ,  Neville Kisalu ,  Azza Idris ,  Barbara Flynn ,  Stephen Hoffman

IPC分类号： C07K16/20

摘要： Antibodies and antigen binding fragments that specifically bind to P. falciparum circumsporozoite protein and neutralize P. falciparum are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. The disclosed antibodies, antigen binding fragments, nucleic acids and vectors can be used, for example, to inhibit a P. falciparum infection.

公开(公告)号：US11760794B2

公开(公告)日：2023-09-19

申请号：US17243455

申请日：2021-04-28

申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES ,  Sanaria Inc.

发明人： Robert Seder ,  Neville Kisalu ,  Azza Idris ,  Barbara Flynn ,  Stephen Hoffman

IPC分类号： C07K16/20

CPC分类号： C07K16/205 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92

摘要： Antibodies and antigen binding fragments that specifically bind to P. falciparum circumsporozoite protein and neutralize P. falciparum are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. The disclosed antibodies, antigen binding fragments, nucleic acids and vectors can be used, for example, to inhibit a P. falciparum infection.

公开(公告)号：US10781419B2

公开(公告)日：2020-09-22

申请号：US15621875

申请日：2017-06-13

申请人： Sanaria Inc. ,  Johns Hopkins University

发明人： Russell H. Taylor ,  Amanda Canezin ,  Mariah Schrum ,  Iulian Iordachita ,  Gregory Chirikjian ,  Michelle Laskowski ,  Sumana Chakravarty ,  Stephen Hoffman

IPC分类号： B01L9/00 ,  C12N3/00 ,  C12N1/10 ,  C12M1/00

摘要： A device and method of use for augmenting the extraction of salivary glands from Plasmodium-infected mosquitoes, where the sporozoite stage of Plasmodium primarily resides. Sporozoites are useful for research as well as for the immunogen in whole parasite vaccines for the prevention of malaria. The device and methods of use disclosed herein greatly increase the rate at which sporozoites can be harvested.