公开(公告)号：US11352334B2

公开(公告)日：2022-06-07

申请号：US16521283

申请日：2019-07-24

申请人： THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH

发明人： Anne Marie Jeanne Bouillot ,  Olivier Mirguet ,  John Liddle ,  Anne Louise Walker

IPC分类号： C07D263/58 ,  C07D413/12 ,  C07C309/30 ,  C07C279/14 ,  C07C211/13 ,  C07C215/10 ,  C07C223/02 ,  C07C229/26 ,  C07C211/27

摘要： A compound of formula (I) or a salt thereof are provided: wherein R1, X and R3 are defined in the specification, useful in the treatment of disorders mediated by KMO such as acute pancreatitis, chronic kidney disease, other conditions associated with systemic inflammatory response syndrome (SIRS), Huntington's disease, Alzheimer's disease, spinocerebellar ataxias, Parkinson's disease, AIDS-dementia complex, amylotrophic lateral sclerosis (ALS), depression, schizophrenia, sepsis, cardiovascular shock, severe trauma, acute lung injury, acute respiratory distress syndrome, acute cholecystitis, severe burns, pneumonia, extensive surgical procedures, ischemic bowel, severe acute hepatic disease, severe acute hepatic encephalopathy or acute renal failure.