公开(公告)号：US11802108B2

公开(公告)日：2023-10-31

申请号：US17269338

申请日：2019-08-29

申请人： The University Court of The University of Edinburgh

发明人： Julien Michel ,  Alessio De Simone ,  Charalampos Ioannidis ,  Jordi Juarez-Jimenez ,  Charis Georgiou ,  Arun Gupta ,  Alison Hulme ,  Malcolm Walkinshaw ,  Dahlia Doughty Shenton

IPC分类号： C07C275/24 ,  C07C323/60 ,  C07D207/16 ,  C07D257/04 ,  C07D403/12 ,  C07D491/08

CPC分类号： C07C275/24 ,  C07C323/60 ,  C07D207/16 ,  C07D257/04 ,  C07D403/12 ,  C07D491/08 ,  C07C2601/02 ,  C07C2601/16

摘要： The present invention relates to compounds of formula (I) or a pharmaceutically acceptable salt thereof useful as inhibitors of Cyclophilins and modulators of cyclophilin-like proteins. The invention also relates to uses of said compounds in the treatment of various disorders. Formula (I), wherein: R1 and R2 are each independently is selected from the group consisting of —R, -haloalkyl, -hydroxyalkyl, —OR, —C(O)R, —CO2R, —C(O)N(R)2, —NRC(O)R, and —N(R)2; wherein R2 could also be a sulphide; each R is independently hydrogen, C1-6 aliphatic, C3-10 aryl, a 3-8 membered saturated or partially unsaturated carbocyclic ring, a 3-7 membered heterocylic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, sulphur, or a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms selected from nitrogen, oxygen, or sulphur; R3 is Formula (Ia) selected from the group consisting of —OEt, and wherein R5 and R6 are independently selected from the group consisting of H, halide, methoxy, thiomethyl, morpholine and trifluoromethyl; R4 is selected from the group consisting of C1-6-alkyl-, and R4.1—CH2— wherein, R4.1 is C3-6-cycloalkyl-, a 5-6 membered heterocyclic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, sulphur; optionally substituted with one R4.1.1 wherein, R4.1.1 is selected from —H, C1-4-alkyl, optionally substituted with one substituent selected from H2N(O)C— or EtO(O)C—; X is carbon or nitrogen; A is selected from the group consisting of 6 membered unsaturated ring, with 1-3 nitrogen atoms, which is optionally substituted by —NH2, and Formula (Ib), wherein ring B is a fused 5-10 membered saturated or partially unsaturated heterocyclic mono-bicyclic ring having 1-3 heteroatoms selected from nitrogen, oxygen or sulphur, which is optionally substituted by —OH; and m is 1 or 2; and n is 1 or 2.

公开(公告)号：US20230323391A1

公开(公告)日：2023-10-12

申请号：US18003021

申请日：2021-06-29

申请人： THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH

发明人： Stuart Robert COBB ,  Paul Ross ,  Ralph David HECTOR ,  Susan ROSSER ,  Adam MOL

IPC分类号： C12N15/86 ,  C12N15/11

CPC分类号： C12N15/86 ,  C12N15/111 ,  C12N2750/14143 ,  C12N2330/51 ,  C12N2310/141 ,  C12N2320/53 ,  C12N2830/42 ,  C12N2830/50 ,  C12N2830/48

摘要： A system to limit the expression of a vector-derived transgene within a window that alleviates the disease-causing genetic deficiency without producing overexpression toxicity is described. This provides for ‘dosage-insensitivity’, whereby cells or tissues receiving more vector-derived transgene are disproportionately suppressed through an in-built single gene circuit that can regulate adaptively.

公开(公告)号：US11696676B2

公开(公告)日：2023-07-11

申请号：US16610802

申请日：2018-05-04

申请人： The University Court of the University of Edinburgh

发明人： Robert R Thomson ,  Debaditya Choudhury ,  Tim Birks

IPC分类号： A61B1/00 ,  A61B1/06 ,  A61B1/07 ,  F21V8/00 ,  G02B6/02 ,  G02B6/024

CPC分类号： A61B1/00165 ,  A61B1/00009 ,  A61B1/00057 ,  A61B1/00126 ,  A61B1/06 ,  A61B1/063 ,  A61B1/0638 ,  A61B1/07 ,  G02B6/0008 ,  G02B6/024 ,  G02B6/02042

摘要： A system comprises a waveguide apparatus comprising a plurality of input waveguides, a multimode waveguide, and a guided-wave transition coupling the plurality of input waveguides to the multimode waveguide. The system further comprises at least one light source configured to excite in turn each of a plurality of the input waveguides, or each of a plurality of combinations of the input waveguides, thereby generating a plurality of different light patterns in turn at an output of the waveguide apparatus. The waveguide apparatus is configured to direct each of the plurality of different light patterns to a target region. The system further comprises at least one detector configured to detect light transmitted, reflected or emitted from the target region in response to each of the different light patterns, and to output signals representing the detected light.

公开(公告)号：US20230134964A1

公开(公告)日：2023-05-04

申请号：US17912150

申请日：2021-03-16

申请人： THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH

发明人： Chaoyun Zhang ,  Paul Patras ,  Marco Fiore

IPC分类号： H04L41/147 ,  H04L41/16 ,  H04L43/028

摘要： To be able to adequately provide desired services over a 5G mobile service network, the 5G communication infrastructures requires a much-improved flexibility in resource management. Network operators are foreseen to deploy network slicing, by isolating dedicated resources and providing customised logical instances of the physical infrastructure to each service. A critical operation in performing management and orchestration of network resources is the anticipatory provisioning of isolated capacity to each network slice. Accordingly, it is necessary to obtain an estimate of service level demands. However, the estimation of such service level demands is typically obtained via deep packet inspection, which is a resource intensive and time-consuming process. Therefore, it is typically not possible to provide updated accurate estimates at a frequency suitable for use in accurate prediction of a future per-service traffic consumption, without an undesirable level of computational and time resources being required. The present invention provides a distributed network traffic data decomposition method which makes use of a neural network to provide an accurate future per-service traffic consumption prediction without deep-packet inspection or another resource intensive analysis method.

公开(公告)号：US11598862B2

公开(公告)日：2023-03-07

申请号：US16689379

申请日：2019-11-20

申请人： The University Court of The University of Edinburgh ,  Sense Photonics, Inc.

发明人： Robert Henderson ,  Hod Finkelstein ,  Neil Calder ,  Tarek Al Abbas

IPC分类号： G01S7/48 ,  G01S7/486 ,  G01S7/4863

摘要： A Light Detection and Ranging (lidar) apparatus includes an emitter array comprising a plurality of emitter units configured to emit optical signals responsive to respective emitter control signals, a detector array comprising a plurality of detector pixels configured to be activated and deactivated for respective strobe windows between pulses of the optical signals; and a control circuit configured to provide a strobe signal to activate a first subset of the detector pixels while leaving a second subset of the detector pixels inactive.

公开(公告)号：US20230023897A1

公开(公告)日：2023-01-26

申请号：US17443410

申请日：2021-07-26

申请人： The University Court of the University of Glasgow ,  THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH

发明人： John Richard MERCER ,  Steven NEALE ,  Anubhav BUSSOOA ,  Daniel HOARE ,  Nosrat MIRZAI ,  Jakub CZYZEWSKI ,  Michael HOLSGROVE ,  Srinjoy MITRA ,  Andreas TSIAMIS ,  Jamie MARLAND

IPC分类号： A61B5/0537 ,  A61B5/00 ,  A61B5/0538 ,  A61N1/375

摘要： A system that provides the ability to integrate both diagnostic tissue detection and therapeutic tissue treatment functionality in an implantable medical device (IMD), such as a graft or stent. The system comprises: an IMD having a pair of electrodes configured to contact biological tissue at an implant location; an impedance sensor configured to detect data indicative of a complex impedance of the biological tissue at the electrodes for a plurality of frequencies; and an analysis device configured to determine one or more cell types in the biological tissue using information indicative of variation in phase and magnitude of the complex impedance across the plurality of frequencies. The system may include a signal generator for applying a treatment signal to the same electrodes.

公开(公告)号：US11544066B2

公开(公告)日：2023-01-03

申请号：US16971419

申请日：2019-02-11

申请人： The University Court of the University of Edinburgh

发明人： Rakesh Kumar ,  Boris Grot ,  Vijay Nagarajan

IPC分类号： G06F9/38

摘要： A branch target buffer, BTB, is provided to store at least one BTB entry corresponding to a respective branch in a control flow in a sequence of machine-readable instructions of a computer program. The BTB has a tag field to compare with a program counter of a fetch address generator and at least one further field to store information characteristic of the branch instruction identified by the corresponding tag field and allowing a conditional branch to be distinguished from an unconditional branch instruction. The BTB has a predetermined storage capacity and is utilized such that unconditional branch instructions are preferentially allocated storage space in the BTB relative to conditional branch instructions.

公开(公告)号：US20220233642A1

公开(公告)日：2022-07-28

申请号：US17610296

申请日：2020-05-15

申请人： THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH

发明人： Sarah Walmsley ,  Moira Whyte ,  Stuart Forbes ,  Ananda Mirchandani Thanwerdas ,  Stephen Jenkins

IPC分类号： A61K38/19 ,  A61P29/00 ,  A61P11/00 ,  A61K35/15 ,  A61K38/20

摘要： The present invention relates to an agent for increasing mononuclear cell number, and/or inducing a pro-restorative phenotype in mononuclear cells for use in the treatment of a lung disease associated with dysfunctional neutrophilic inflammation, particularly wherein the agent is CSF1 and the lung disease is acute respiratory distress syndrome (ARDS).

公开(公告)号：US11352334B2

公开(公告)日：2022-06-07

申请号：US16521283

申请日：2019-07-24

申请人： THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH

发明人： Anne Marie Jeanne Bouillot ,  Olivier Mirguet ,  John Liddle ,  Anne Louise Walker

IPC分类号： C07D263/58 ,  C07D413/12 ,  C07C309/30 ,  C07C279/14 ,  C07C211/13 ,  C07C215/10 ,  C07C223/02 ,  C07C229/26 ,  C07C211/27

摘要： A compound of formula (I) or a salt thereof are provided: wherein R1, X and R3 are defined in the specification, useful in the treatment of disorders mediated by KMO such as acute pancreatitis, chronic kidney disease, other conditions associated with systemic inflammatory response syndrome (SIRS), Huntington's disease, Alzheimer's disease, spinocerebellar ataxias, Parkinson's disease, AIDS-dementia complex, amylotrophic lateral sclerosis (ALS), depression, schizophrenia, sepsis, cardiovascular shock, severe trauma, acute lung injury, acute respiratory distress syndrome, acute cholecystitis, severe burns, pneumonia, extensive surgical procedures, ischemic bowel, severe acute hepatic disease, severe acute hepatic encephalopathy or acute renal failure.

公开(公告)号：US20220136069A1

公开(公告)日：2022-05-05

申请号：US17436161

申请日：2020-03-06

申请人： The University Court of the University of Edinburgh

发明人： Jeff Pollard ,  Luca Cassetta ,  Stamatina Fragkogianni

IPC分类号： C12Q1/6886

摘要： The present invention relates to the field of breast cancer diagnosis and treatment. The present invention provides methods comprising a) analysing a biological sample obtained from a subject to determine the presence of target molecules representative of expression of at least two biomarkers selected from the group listed in Table 1, wherein the biological sample is a breast tissue sample or derivative thereof; and b) comparing the expression levels of the biomarkers determined in (a) with one or more reference values, wherein whether there is a difference in the expression of the biomarkers in the sample from the subject compared to the one or more reference values is indicative of a clinical indication. The invention further provides methods of treatment and kits and assays for use in the methods of the invention.