公开(公告)号：US20180085335A1

公开(公告)日：2018-03-29

申请号：US15278916

申请日：2016-09-28

申请人： THE UNIVERSITY OF HONG KONG

发明人： Hongzhe SUN ,  Richard Yi Tsun KAO ,  Runming WANG ,  Tsz Pui LAI ,  Hongmin ZHANG ,  Hongyan LI

IPC分类号： A61K31/28 ,  A61K31/407

CPC分类号： A61K33/245 ,  A61K31/407 ,  A61K31/4196 ,  A61K31/427 ,  A61K31/431 ,  Y02A50/473 ,  A61K2300/00

摘要： The present disclosure relates to a pharmaceutical composition comprising: (a) β-lactam antibiotics and (b) a metallo-β-lactamases (MBLs) inhibitor. The inhibitor relates to Bi(III) compounds or the pharmaceutically acceptable salts thereof. The present patent also provides methods of making Bi(III) compounds or the pharmaceutically acceptable salts thereof. Also provided is a method for treating MBLs-producing bacterial infection using a metal replacement mechanism.

公开(公告)号：US20190201370A1

公开(公告)日：2019-07-04

申请号：US16242352

申请日：2019-01-08

申请人： THE UNIVERSITY OF HONG KONG

发明人： Hongzhe SUN ,  Richard Yi Tsun KAO ,  Runming WANG ,  Tsz Pui LAI ,  Hongmin ZHANG ,  Hongyan LI

IPC分类号： A61K31/28 ,  A61K31/431 ,  A61K33/245 ,  A61K31/407 ,  A61K31/427 ,  A61K31/4196

CPC分类号： A61K31/28 ,  A61K31/407 ,  A61K31/4196 ,  A61K31/427 ,  A61K31/431 ,  A61K33/245 ,  Y02A50/473 ,  A61K2300/00

摘要： The present disclosure relates to a pharmaceutical composition comprising: (a) β-lactam antibiotics and (b) a metallo-β-lactamases (MBLs) inhibitor. The inhibitor relates to Bi(III) compounds or the pharmaceutically acceptable salts thereof. The present patent also provides methods of making Bi(III) compounds or the pharmaceutically acceptable salts thereof. Also provided is a method for treating MBLs-producing bacterial infection using a metal replacement mechanism.