公开(公告)号：US20180085335A1

公开(公告)日：2018-03-29

申请号：US15278916

申请日：2016-09-28

申请人： THE UNIVERSITY OF HONG KONG

发明人： Hongzhe SUN ,  Richard Yi Tsun KAO ,  Runming WANG ,  Tsz Pui LAI ,  Hongmin ZHANG ,  Hongyan LI

IPC分类号： A61K31/28 ,  A61K31/407

CPC分类号： A61K33/245 ,  A61K31/407 ,  A61K31/4196 ,  A61K31/427 ,  A61K31/431 ,  Y02A50/473 ,  A61K2300/00

摘要： The present disclosure relates to a pharmaceutical composition comprising: (a) β-lactam antibiotics and (b) a metallo-β-lactamases (MBLs) inhibitor. The inhibitor relates to Bi(III) compounds or the pharmaceutically acceptable salts thereof. The present patent also provides methods of making Bi(III) compounds or the pharmaceutically acceptable salts thereof. Also provided is a method for treating MBLs-producing bacterial infection using a metal replacement mechanism.

公开(公告)号：US20190201370A1

公开(公告)日：2019-07-04

申请号：US16242352

申请日：2019-01-08

申请人： THE UNIVERSITY OF HONG KONG

发明人： Hongzhe SUN ,  Richard Yi Tsun KAO ,  Runming WANG ,  Tsz Pui LAI ,  Hongmin ZHANG ,  Hongyan LI

IPC分类号： A61K31/28 ,  A61K31/431 ,  A61K33/245 ,  A61K31/407 ,  A61K31/427 ,  A61K31/4196

CPC分类号： A61K31/28 ,  A61K31/407 ,  A61K31/4196 ,  A61K31/427 ,  A61K31/431 ,  A61K33/245 ,  Y02A50/473 ,  A61K2300/00

摘要： The present disclosure relates to a pharmaceutical composition comprising: (a) β-lactam antibiotics and (b) a metallo-β-lactamases (MBLs) inhibitor. The inhibitor relates to Bi(III) compounds or the pharmaceutically acceptable salts thereof. The present patent also provides methods of making Bi(III) compounds or the pharmaceutically acceptable salts thereof. Also provided is a method for treating MBLs-producing bacterial infection using a metal replacement mechanism.

公开(公告)号：US20230218663A1

公开(公告)日：2023-07-13

申请号：US18000491

申请日：2021-05-31

申请人： THE UNIVERSITY OF HONG KONG

发明人： Hongzhe SUN ,  Kwok-Yung YUEN ,  Shuofeng YUAN ,  Runming WANG ,  Hongyan LI ,  Fuk-Woo CHAN ,  Tianfan CHENG ,  Suyu WANG

IPC分类号： A61K33/245 ,  A61P31/14 ,  A61K45/06

CPC分类号： A61K33/245 ,  A61P31/14 ,  A61K45/06 ,  A61K9/0053

摘要： Compositions and methods for treating a subject for a SARS-CoV-2 infection in a subject in need thereof are disclosed. The composition includes one or more Bismuth (III)-containing compounds, an analog thereof, or pharmaceutically acceptable salt thereof in a pharmaceutically acceptable carrier, and are used alone or in combination with a thiol-containing small molecule compound. Exemplary Bismuth (III)-containing compounds include Colloidal Bismuth Subcitrate (CBS); ranitidine bismuth citrate (RBC); Bi (TPP) (TPP: tetraphenylporphyrinate); and Bi (TPyP) (TPyP: tetra (4-pyridyl) porphyrin). The disclosed compounds and compositions can be used to treat a SARS-CoV-2 infection in a subject in need thereof. The compositions can be administered to a subject presently suffering from an infection of the SARS-CoV-2, who is exhibiting one or more symptoms of COVID-19. The compositions can also be administered to a subject that has been exposed to the SARS-CoV-2 but is asymptomatic.