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公开(公告)号：US10912838B2
公开(公告)日：2021-02-09
申请号：US15902255
申请日：2018-02-22
发明人： Kazunori Kataoka , Yasutaka Anraku , Nobuhiro Nishiyama , Kanjiro Miyata , Takehiko Ishii , Yu Matsumoto , Yu Fukusato , Akihiro Mizoguchi , Takanori Yokota , Hiroya Kuwahara , Kazutaka Nishina , Hidehiro Mizusawa
IPC分类号： A61K47/60 , A61K9/127 , A61K31/7088 , B01J13/02 , A61K47/54 , C08G81/00 , C08G69/10 , C08G69/40 , C07K16/00 , A61K47/64 , A61K47/69 , A61K9/00 , A61K39/44 , A61K39/00
摘要： The present invention provides a vesicle, a conjugate, a composition comprising the vesicle or the conjugate, for use in delivering a drug to the brain, and a method for administering the same. The composition of the present invention is a composition for administration to a subject according to a dosing regimen, comprising a carrier for drug delivery, wherein the dosing regimen comprises administering the composition to a subject who has been fasted or caused to have hypoglycemia and inducing an increase in blood glucose level in the subject, and the carrier is modified at the outer surface thereof with a GLUT1 ligand.
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2.发明申请公开(公告)号：US20180185501A1
公开(公告)日：2018-07-05
申请号：US15902255
申请日：2018-02-22
发明人： Kazunori Kataoka , Yasutaka Anraku , Nobuhiro Nishiyama , Kanjiro Miyata , Takehiko Ishii , Yu Matsumoto , Yu Fukusato , Akihiro Mizoguchi , Takanori Yokota , Hiroya Kuwahara , Kazutaka Nishina , Hidehiro Mizusawa
IPC分类号： A61K47/60 , C08G81/00 , A61K47/69 , C08G69/10 , B01J13/02 , C08G69/40 , A61K47/54 , A61K47/64 , A61K39/44 , A61K31/7088 , A61K9/127 , A61K9/00 , A61K39/00
CPC分类号： A61K47/60 , A61K9/0019 , A61K9/127 , A61K31/7088 , A61K39/44 , A61K47/543 , A61K47/549 , A61K47/554 , A61K47/645 , A61K47/6455 , A61K47/6905 , A61K47/6907 , A61K47/6911 , A61K2039/505 , A61K2039/54 , A61K2039/545 , A61K2039/6093 , B01J13/02 , C07K16/00 , C07K2317/10 , C07K2317/94 , C08G69/10 , C08G69/40 , C08G81/00
摘要： The present invention provides a vesicle, a conjugate, a composition comprising the vesicle or the conjugate, for use in delivering a drug to the brain, and a method for administering the same. The composition of the present invention is a composition for administration to a subject according to a dosing regimen, comprising a carrier for drug delivery, wherein the dosing regimen comprises administering the composition to a subject who has been fasted or caused to have hypoglycemia and inducing an increase in blood glucose level in the subject, and the carrier is modified at the outer surface thereof with a GLUT1 ligand.
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公开(公告)号：US09937263B2
公开(公告)日：2018-04-10
申请号：US15038374
申请日：2014-11-21
发明人： Kazunori Kataoka , Yasutaka Anraku , Nobuhiro Nishiyama , Kanjiro Miyata , Takehiko Ishii , Yu Matsumoto , Yu Fukusato , Akihiro Mizoguchi , Takanori Yokota , Hiroya Kuwahara , Kazutaka Nishina , Hidehiro Mizusawa
IPC分类号： A61K9/127 , A61K47/48 , A61K31/7088 , B01J13/02 , C08G81/00 , C08G69/10 , C08G69/40 , A61K9/00 , A61K39/44 , A61K47/60 , A61K47/54 , A61K47/64 , A61K47/69 , A61K39/00
CPC分类号： A61K47/60 , A61K9/0019 , A61K9/127 , A61K31/7088 , A61K39/44 , A61K47/543 , A61K47/549 , A61K47/554 , A61K47/645 , A61K47/6455 , A61K47/6905 , A61K47/6907 , A61K47/6911 , A61K2039/505 , A61K2039/54 , A61K2039/545 , A61K2039/6093 , B01J13/02 , C07K16/00 , C07K2317/10 , C07K2317/94 , C08G69/10 , C08G69/40 , C08G81/00
摘要： The present invention provides a vesicle, a conjugate, a composition comprising the vesicle or the conjugate, for use in delivering a drug to the brain, and a method for administering the same. The composition of the present invention is a composition for administration to a subject according to a dosing regimen, comprising a carrier for drug delivery, wherein the dosing regimen comprises administering the composition to a subject who has been fasted or caused to have hypoglycemia and inducing an increase in blood glucose level in the subject, and the carrier is modified at the outer surface thereof with a GLUT1 ligand.
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