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    AMPHIPHILIC POLY (AMINO ACID), BLOCK COPOLYER USING THE AMPHIPHILIC POLY (AMINO ACID), AND COMPLEX INCLUDING THE AMPHIPHILIC POLY (AMINO ACID) OR THE BLOCK COPOLYMER AND NUCLEIC ACID
    4.
    发明申请
    AMPHIPHILIC POLY (AMINO ACID), BLOCK COPOLYER USING THE AMPHIPHILIC POLY (AMINO ACID), AND COMPLEX INCLUDING THE AMPHIPHILIC POLY (AMINO ACID) OR THE BLOCK COPOLYMER AND NUCLEIC ACID 有权

    公开(公告)号：US20210340322A1

    公开(公告)日：2021-11-04

    申请号：US17280058

    申请日：2019-09-25

    申请人： The University of Tokyo

    发明人： HyunJin Kim ,  Kanjiro Miyata ,  Kazunori Kataoka

    IPC分类号： C08G69/10 ,  C08F293/00 ,  C08L77/04 ,  A61K47/64 ,  A61K31/7105 ,  C12N15/87

    摘要： The present invention provides an amphiphilic poly(amino acid) for nucleic acid delivery, which is represented by the following formula (1): where: R1 represents a hydroxy group, an oxybenzyl group, an —O—R1a group, or an —NH—R1b group, where R1a and R1b each independently represent an unsubstituted or substituted, linear or branched alkyl group having 1 to 12 carbon atoms; R2 represents a hydrogen atom, an unsubstituted or substituted, linear or branched alkyl group having 1 to 12 carbon atoms, or an unsubstituted or substituted, linear or branched alkylcarbonyl group having 1 to 24 carbon atoms; R3a, R3b, R4a, and R4b each independently represent a methylene group or an ethylene group; R5a and R5b each independently represent —O— or —NH—; R6a and R6b each independently represent an unsubstituted or substituted aliphatic hydrocarbon group having 7 to 12 carbon atoms that may contain an alicycle; R7a and R7b are each independently selected from groups identical to or different from each other in the group consisting of the following groups: —NH—(CH2)p1—[NH—(CH2)q1—]r1NH2 (i); —NH—(CH2)p2—N[—(CH2)q2—NH2]2 (ii); —NH—(CH2)p3—N{[—(CH2)q3—NH2][—(CH2)q4—NH—]r2H} (iii); and —NH—(CH2)p4—N{—(CH2)q5—N[—(CH2)q6—NH2]2}2 (iv), where p1 to p4, q1 to q6, and r1 and r2 each independently represent an integer of from 1 to 5; R8 represents a side chain of an amino acid selected from the group consisting of ornithine, lysine, homolysine, arginine, homoarginine, and histidine; m represents an integer of 9 or more; n represents an integer of from 0 to m; x represents an integer of from 2 to 300; y represents an integer of from 0 to x; and z represents an integer of from 0 to x, provided that a relationship of y+z≤x and a relationship of 11≤m+x≤400 are satisfied, and repeating units in the formula (1) may be randomly present.