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公开(公告)号：US10435509B2
公开(公告)日：2019-10-08
申请号：US15740252
申请日：2016-06-29
发明人： Kazushi Kinbara , Takahiro Muraoka , Adam Marcin Wawro , Tomoyuki Ohtake , Eui-chul Kang , Tomoki Uruga , Ryutaro Imamura
IPC分类号： C08G65/46 , C08G65/333 , C08G65/334 , B01D11/04 , B01D15/36 , C08G65/48
摘要： A hetero type monodispersed polyethylene glycol containing a compound represented by the following formula (1): NH2—(CH2CH2O)a—CH2CH2COOH (1) (in the formula (1), a represents an integer from 6 to 40); wherein any of (A) a chromatogram detected by a differential refractometer when the hetero type monodispersed polyethylene glycol is separated using reverse phase chromatography, (B) a chromatogram detected by a differential refractometer when the hetero type monodispersed polyethylene glycol is separated using cation exchange chromatography, and (C) a chromatogram detected by a differential refractometer when the hetero type monodispersed polyethylene glycol containing a compound represented by the formula (1) shown above is derivatized and separated using anion exchange chromatography satisfy specific relational expressions, respectively.
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2.发明公开公开(公告)号：US20230192953A1
公开(公告)日：2023-06-22
申请号：US18168162
申请日：2023-02-13
发明人： Kazushi Kinbara , Tomoki Uruga , Tomoyuki Ohtake
IPC分类号： C08G65/333 , A61K47/60
CPC分类号： C08G65/33396 , A61K47/60
摘要： An intermediate for production of a branched type hetero monodispersed polyethylene glycol which is represented by formula (2), the intermediate being represented by formula (3) or (40):
where X1, L1, L3, Y1, Y2, and n are as defined herein.-
公开(公告)号：US11613607B2
公开(公告)日：2023-03-28
申请号：US16338873
申请日：2017-10-06
发明人： Kazushi Kinbara , Tomoki Uruga , Tomoyuki Ohtake
IPC分类号： C08G65/329 , C08G65/333 , A61K47/60 , A61K47/68
摘要： A branched type hetero monodispersed polyethylene glycol represented by formula (1) where X1, Y1, n, E, L1, L2 and L3 are as defined herein.
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