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公开(公告)号：US20240277855A1
公开(公告)日：2024-08-22
申请号：US18435636
申请日：2024-02-07
发明人： Akira ONODA , Takashi HAYASHI , Ken HAMURA , Akira SUZUKI , Satoshi KISHIDA
CPC分类号： A61K47/60 , A61K47/545 , C12N9/22
摘要： Polyoxyethylene derivatives represented by the following formula (1) provided by the present invention:
wherein the symbols in the formula are as defined in the specification, can form conjugates with polypeptide that can be degraded over a long time under physiological conditions to release the polypeptide.-
2.发明公开公开(公告)号：US20240268022A1
公开(公告)日：2024-08-08
申请号：US18289769
申请日：2022-08-23
申请人： NOF CORPORATION
IPC分类号： H05K1/05 , C23C16/40 , C23C16/448 , H01L21/48 , H01L23/373 , H05K1/02 , H05K3/44
CPC分类号： H05K1/053 , C23C16/403 , C23C16/4486 , H01L21/4846 , H01L23/3735 , H05K1/0209 , H05K3/44 , H05K2201/0179 , H05K2201/0191 , H05K2203/088
摘要： According to the present invention, a heat-dissipating circuit board is formed by providing a metal material adjacent to one surface of an insulating layer and providing a conductive metal layer to the other surface of the insulating layer. The metal material is a sheet of copper or a copper alloy or aluminum or an aluminum alloy and is 0.2-20 mm thick. The insulating layer is a metal oxide layer that has the composition AlxOyTz, is 0.2-30 μm thick, has a volume resistivity of at least 1000 GΩ·cm, and has a porosity of no more than 10%. The heat-dissipating circuit board has excellent heat-dissipation properties and insulation properties.
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公开(公告)号：US12018120B2
公开(公告)日：2024-06-25
申请号：US17436738
申请日：2020-03-25
申请人： NOF CORPORATION
IPC分类号： C08G65/332
CPC分类号： C08G65/3322
摘要： A method for producing a terminal carboxyl group-containing polyethylene glycol, which includes the following steps 1 and 2. Step 1: In a solution containing a polyethylene glycol having a hydroxyl group, an inorganic base 0.5 to 4 times the polyethylene glycol in mass, an aprotic solvent and water, mass of the water being 5 to 20 meq with respect to the inorganic base and mass of the water in the solution being 2,000 ppm or less, a compound of the formula (1) is reacted with the polyethylene glycol to obtain a polyethylene glycol ester:
wherein X represents a leaving group, a represents an integer of 4 to 9, and R1 represents a hydrocarbon group having 1 to 4 carbon atoms; Step 2: The polyethylene glycol ester is hydrolyzed to obtain a terminal carboxyl group-containing polyethylene glycol.-
4.发明公开公开(公告)号：US20240101734A1
公开(公告)日：2024-03-28
申请号：US18263416
申请日：2022-01-21
申请人： NOF CORPORATION
发明人： Hirotaka SUZUKI , Seina KONDO , Masaru MATSUDA
IPC分类号： C08F120/34 , C08F30/02 , C08F130/02 , C08F220/06 , C08F230/02 , C12Q1/6851 , C12Q1/70
CPC分类号： C08F120/34 , C08F30/02 , C08F130/02 , C08F220/06 , C08F230/02 , C12Q1/6851 , C12Q1/70
摘要： The present invention provides a sensitizer for nucleic acid amplification which is a polymer containing a constitutional unit derived from a monomer represented by the following formula (1):
wherein symbols are as defined in the specification.-
公开(公告)号：US11867875B2
公开(公告)日：2024-01-09
申请号：US17275799
申请日：2019-09-10
申请人： NOF CORPORATION
发明人： Ryuya Gotanda , Koh Kobayashi , Shu Takashima , Norio Iwakiri , Yosuke Matsuoka , Eiji Harata
IPC分类号： C08F230/08 , G02B1/04 , G02C7/04
CPC分类号： G02B1/043 , C08F230/08 , G02C7/049
摘要： Provided is a contact lens that can exhibit excellent breaking elongation and surface hydrophilicity even when produced using a hydrophobic mold made of polypropylene or the like without performing a surface hydrophilic treatment. Further provided are a monomer composition and a polymer that can be suitably used for obtaining the contact lens. This monomer composition contains (A) a siloxanyl group-containing itaconic acid diester monomer, (B) an amide group-containing monomer, (C) a hydroxy group-containing monomer, (D) a siloxanyl group-containing (meth)acrylate, and (E) a cross-linking agent in a specific ratio.
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公开(公告)号：US20230338387A1
公开(公告)日：2023-10-26
申请号：US17760181
申请日：2021-02-03
申请人： NOF CORPORATION
IPC分类号： A61K31/536 , A61K31/365 , A61K47/10 , A61K9/00 , A61P1/18
CPC分类号： A61K31/536 , A61K31/365 , A61K47/10 , A61K9/0024 , A61P1/18
摘要： The present invention provides a prophylactic or therapeutic agent for the leakage of pancreatic juice and/or pancreatic fistula after abdominal surgery, containing a lipase inhibitor as an active ingredient, and a method for preventing or treating leakage of pancreatic juice and/or pancreatic fistula after abdominal surgery, including administering an effective amount of a lipase inhibitor to a mammal in need of the administration thereof.
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公开(公告)号：US11746308B2
公开(公告)日：2023-09-05
申请号：US16767370
申请日：2018-12-03
申请人： NOF CORPORATION
IPC分类号： C11D3/00 , C08F230/02 , C08L43/02 , G02C7/04
CPC分类号： C11D3/0078 , C08F230/02 , C08L43/02 , G02C7/04
摘要： Provided is a treating solution for soft contact lenses capable of imparting hydrophilicity and sustainability thereof to a soft contact lens surface. It has been found that a treating solution for soft contact lenses containing a copolymer that contains two kinds of monomers different from each other as constituent units at a specific ratio, and that has a specific weight-average molecular weight can impart excellent hydrophilicity and sustainability thereof.
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公开(公告)号：US11744792B2
公开(公告)日：2023-09-05
申请号：US17424162
申请日：2020-01-16
申请人： NOF CORPORATION
发明人： Dai Murakami , Tomohiro Wakita
CPC分类号： A61K8/92 , A61K8/0216 , A61K8/345 , A61Q19/10 , A61K2800/591
摘要： A solid soap containing, (A) 77 to 91 mass % of an alkali metal salt of a saturated fatty acid having an even number of carbon atoms from 12 to 18, (B) 0.005 to 1 mass % of an alkali metal salt of a saturated fatty acid having an odd number of carbon atoms from 13 to 17, (C) 0.5 to 5 mass % of glycerol, and (D) 5 to 18 mass % of water.
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公开(公告)号：US11680137B2
公开(公告)日：2023-06-20
申请号：US17042331
申请日：2019-03-26
申请人： NOF CORPORATION
发明人： Koichi Ogi , Takuma Tsubusaki , Kohei Yoshimura
IPC分类号： C08G65/30 , C08G65/324 , C08G65/329 , C08G65/46 , C08G65/48
CPC分类号： C08G65/30 , C08G65/324 , C08G65/329 , C08G65/46 , C08G65/48
摘要： A method for purifying a specific trityl group-containing monodispersed polyethylene glycol from a mixture containing the trityl group-containing monodispersed polyethylene glycol and a specific ditritylated impurity. The method includes performing steps (A), (B) and (C). Step (A): a step of esterifying the hydroxyl group of the trityl group-containing monodispersed polyethylene glycol by a specific method; Step (B): a step of extracting the esterified compound by a specific method; and Step (C): a step of hydrolyzing the esterified compound to obtain the trityl group-containing monodispersed polyethylene glycol.
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公开(公告)号：US20230127080A1
公开(公告)日：2023-04-27
申请号：US17907368
申请日：2021-03-19
发明人： Shinya TAMAGAWA , Kota TANGE , Yuta NAKAI , Masamichi TAMADA , Hidetaka AKITA , Hiroki TANAKA , Yu SAKURAI
摘要： The present invention provides, a cationic lipid represented by the formula (1) (wherein each symbol is as defined in the specification), a lipid membrane structure using the aforementioned cationic lipid, a nucleic acid-introducing agent using the aforementioned cationic lipid, and a method for introducing a nucleic acid by using the aforementioned nucleic acid-introducing agent.
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