公开(公告)号：US20230192953A1

公开(公告)日：2023-06-22

申请号：US18168162

申请日：2023-02-13

申请人： Tokyo Institute of Technology ,  NOF Corporation

发明人： Kazushi Kinbara ,  Tomoki Uruga ,  Tomoyuki Ohtake

IPC分类号： C08G65/333 ,  A61K47/60

CPC分类号： C08G65/33396 ,  A61K47/60

摘要： An intermediate for production of a branched type hetero monodispersed polyethylene glycol which is represented by formula (2), the intermediate being represented by formula (3) or (40):




where X1, L1, L3, Y1, Y2, and n are as defined herein.

公开(公告)号：US20230192952A1

公开(公告)日：2023-06-22

申请号：US18168119

申请日：2023-02-13

申请人： TOKYO INSTITUTE OF TECHNOLOGY ,  NOF CORPORATION

发明人： Kazushi KINBARA ,  Tomoki Uruga ,  Tomoyuki Ohtake

IPC分类号： C08G65/333 ,  A61K47/60

CPC分类号： C08G65/33396 ,  A61K47/60

摘要： A method of producing a compound represented by formula (3):




includes: step (1) of performing coupling of a monodispersed polyethylene glycol derivative represented by formula (4) shown below with a compound represented by formula (5) shown below using a base catalyst having a pKa in an aqueous solution of 15 to 20 to obtain a compound represented by formula (6) shown below, step (2) of deprotecting the protective group A of the compound represented by the formula (6) to obtain a compound represented by formula (7) shown below, and step (3) of subjecting the compound represented by the formula (7) to separatory purification; and step (4) of subjecting the compound represented by the formula (7) to deprotection treatment or reduction treatment to obtain the compound represented by formula (3), in an order described above, where Y2, n, A, B, and Z are as defined herein:

公开(公告)号：US11613607B2

公开(公告)日：2023-03-28

申请号：US16338873

申请日：2017-10-06

申请人： TOKYO INSTITUTE OF TECHNOLOGY ,  NOF CORPORATION

发明人： Kazushi Kinbara ,  Tomoki Uruga ,  Tomoyuki Ohtake

IPC分类号： C08G65/329 ,  C08G65/333 ,  A61K47/60 ,  A61K47/68

摘要： A branched type hetero monodispersed polyethylene glycol represented by formula (1) where X1, Y1, n, E, L1, L2 and L3 are as defined herein.

公开(公告)号：US10435509B2

公开(公告)日：2019-10-08

申请号：US15740252

申请日：2016-06-29

申请人： TOHOKU TECHNO ARCH CO., LTD. ,  NOF CORPORATION

发明人： Kazushi Kinbara ,  Takahiro Muraoka ,  Adam Marcin Wawro ,  Tomoyuki Ohtake ,  Eui-chul Kang ,  Tomoki Uruga ,  Ryutaro Imamura

IPC分类号： C08G65/46 ,  C08G65/333 ,  C08G65/334 ,  B01D11/04 ,  B01D15/36 ,  C08G65/48

摘要： A hetero type monodispersed polyethylene glycol containing a compound represented by the following formula (1): NH2—(CH2CH2O)a—CH2CH2COOH  (1) (in the formula (1), a represents an integer from 6 to 40); wherein any of (A) a chromatogram detected by a differential refractometer when the hetero type monodispersed polyethylene glycol is separated using reverse phase chromatography, (B) a chromatogram detected by a differential refractometer when the hetero type monodispersed polyethylene glycol is separated using cation exchange chromatography, and (C) a chromatogram detected by a differential refractometer when the hetero type monodispersed polyethylene glycol containing a compound represented by the formula (1) shown above is derivatized and separated using anion exchange chromatography satisfy specific relational expressions, respectively.